95 results about "Dialysis solutions" patented technology

The invention discloses an MPSO-based dialysis solution preparation stirring parameter adaptive adjustment method, and relates to the technical field of dialysis solution preparation, and the method comprises the steps: initializing a digital twin model and a causal reasoning network, constructing a physical structure virtual mapping of a solution preparation device, calibrating parameters, and forming a calibrated virtual-real mapping decision support environment; on the basis of a virtual-real mapping decision support environment, multi-dimensional process data of historical prepared liquid batches are preprocessed, a causal discovery algorithm is adopted to update a causal reasoning network, a dialysis prepared liquid stirring parameter and prepared liquid quality causal relationship graph is learned, and a dynamically updated causal relationship network is established; and based on the dynamically updated causal relationship network, searching an optimal solution of a fitness function through particle swarm iteration, and generating a virtual environment pre-optimization parameter set. According to the method, key parameters such as the pump power, the turbulence angle and the stirring time can be adaptively searched and re-corrected under multiple working conditions through a particle swarm optimization mechanism based on MPSO in the dynamic virtual environment.

The invention provides a nano-phase penthorum chinense pursh extract, which is prepared by the following steps: soaking a penthorum chinense pursh medicinal material, decocting, filtering, collecting filtrate, carrying out layering centrifugation to remove precipitate, dialyzing supernate by adopting a dialysis bag with the molecular weight cutoff of 3.5 kDa, and freeze-drying dialysate to obtain the nano-phase penthorum chinense pursh extract. The invention further provides a preparation method and application of the nanometer phase-state penthorum chinense pursh extract. The invention provides an extraction method capable of accurately separating 50-200nm phase-state active components in a nanometer phase-state penthorum chinense pursh extract traditional Chinese medicine. Organic solvents are prevented from being used, and the safety of extracted products is improved; the purity of the target component is improved; the structural integrity of a natural nanometer phase state is kept; the obtained nanometer phase-state extract has the effects of remarkably improving metabolic dysfunction related steatohepatitis and resisting coagulation, is high in separation efficiency, can be completed in 2-3 days, and can be applied on a large scale; the equipment is simple and low in cost.

The invention relates to the technical field, in particular to a dialysate supply system of a hemodialysis machine, which comprises a concentrated solution supply module, a dialysate mixing module, a concentration detection module, a data storage module, an intelligent control module and a centralized control module, the real-time state of a patient is dynamically analyzed through deep learning, components of dialysate are automatically adjusted, the crossing from a fixed formula to individualized dynamic supply is achieved, and the treatment effect is remarkably improved; secondly, the system can predict the risks of hypotension, hyperkalemia and the like prospectively, and actively intervene in advance, so that the incidence rate of dialysis-related acute complications is reduced; and moreover, the workload of medical staff for frequently and manually adjusting parameters is greatly reduced through automatic intelligent control, so that the medical staff can concentrate on clinical decisions, and medical resource allocation is optimized.

The invention relates to the technical field of peritoneal dialysis monitoring, and discloses a dynamic weighing and data fusion peritoneal dialysis solution balance monitoring system and method. The system comprises a dynamic weighing module, a multi-source data acquisition module, a data fusion processing module, a balance monitoring module and an early warning output module. The dynamic weighing module collects dialysate input and discharge amount in real time and generates weight data; the multi-source data acquisition module is used for acquiring dialysate components, treatment time and physiological parameters of a patient; the data fusion processing module is used for fusing the data to generate dialysate balance characteristic data; the balance monitoring module is used for calculating the net ultrafiltration amount and the liquid balance state and identifying the risk of abnormal leakage or liquid retention; and the early warning output module generates early warning information when the risk is identified. The system does not need manual intervention, can collect and fuse multi-source data in real time, accurately judge the liquid balance state and give an early warning in time, and is suitable for hospital and home peritoneal dialysis scenes.

A method for incorporating at least one organic compound within a hydrogel, wherein the incorporation is carried out by dialysis, the organic compound being solubilized in the dialysis solution at a concentration equal to or greater than the target concentration.

The invention belongs to the technical field of hemodialysis concentrated solution production, and particularly relates to a hemodialysis concentrated solution preparing and mixing device which comprises a bottom plate and further comprises two supporting legs, the number of the supporting legs is two, and the bottom ends of the two supporting legs are both fixedly installed at the top of the bottom plate; the bottom and the right end of the mixing cylinder are fixedly mounted on the two supporting legs respectively, and a feeding opening is formed in the top of the mixing cylinder; the stirring assembly is arranged in the mixing cylinder, and the stirring assembly is used for stirring and mixing the dialysate; the discharging assembly comprises a discharging pipe, an electric control valve, a filtering box and a filtering net, efficient mixing in the dialysate preparation process and filtering in the discharging process are achieved through a simple structure, the production quality of the dialysate is improved, meanwhile, the prepared dialysate can be subjected to split charging processing, the production cost is reduced, and the production efficiency is improved. And the processing efficiency of the dialysate is improved, and the practicability is high.

The utility model discloses a hemodialysis concentrated solution packaging bag, and relates to the technical field of hemodialysis packaging bags, the hemodialysis concentrated solution packaging bag comprises a vertical packaging bag, a bag body and a material nozzle, the top end of the bag body is provided with a bag opening, the material nozzle is in heat seal connection with the bag opening, the bag body is in heat seal connection with a handle, and the material nozzle is provided with an inner cover; the wrist ring comprises a wrist ring and a wrist ring, the wrist ring comprises an inner cover and an outer cover, the anti-mistaken-opening mechanism comprises an outer cover, a first moving groove and an elastic piece, the first moving groove is formed in the inner wall of the outer cover, and the outer side of the inner cover is movably connected with the inner wall of the first moving groove. The packaging bag is limited at the wrist position, the packaging bag is effectively prevented from falling on the ground, the mistaken opening prevention function is achieved through the mistaken opening prevention mechanism, the situation that the cover is accidentally opened due to mistaken touch or other reasons in the non-use state is effectively avoided, concentrated liquid is prevented from being polluted, and the quality of dialysate and the use safety are guaranteed.

The utility model relates to a peritoneal dialysis solution sample transport box, which comprises a box body, a thermal insulation layer, a refrigeration device and a sealing cover, the box body is provided with a containing cavity used for containing a peritoneal dialysis solution sample, and the thermal insulation layer wraps the outer wall of the box body and is used for blocking external high temperature. The refrigeration device is arranged in the containing cavity and comprises a shell, a power box, a semiconductor refrigeration sheet and a cooling fin, the shell is installed in the box body, the semiconductor refrigeration sheet and the cooling fin are connected with the power box through wires, an installation hole is formed in the top of the shell, and one side of the cooling fin is inserted into the installation hole and fixedly connected with the shell; the other side clings to the hot surface of the semiconductor chilling plate; the sealing cover is detachably connected with the box body and used for sealing the containing cavity. The temperature in the box body is reduced by utilizing the refrigerating device, so that the peritoneal dialysis solution sample is refrigerated, the deterioration time of the peritoneal dialysis solution sample is delayed, and the accuracy of a detection result is improved.

The invention provides a carbon quantum dot and small nucleic acid nanocomposite, which is formed by wrapping the outer layer of a positively charged carbon quantum dot with negatively charged siRNA through electrostatic interaction, the carbon quantum dot is a histidine-doped chitosan quantum dot or arginine-doped chitosan quantum dot, chitosan is dissolved in an acetic acid solution, and the small nucleic acid and the chitosan are mixed to form the nanocomposite. The preparation method comprises the following steps: continuously adding amino acid, stirring until the amino acid is dissolved, treating for 6-8 hours at the temperature of 100-180 DEG C to obtain a mixture, cooling the mixture to room temperature, centrifuging, passing through a filter membrane with the pore diameter of 0.22-0.45 mu m, dialyzing the obtained filtrate in ultrapure water for 8-12 hours by using a dialysis bag with the MWCO value of 800-1000Da, freeze-drying the residual dialysate in the dialysis bag to obtain carbon quantum dots, mixing the carbon quantum dots with free siRNA, and performing freeze-drying on the carbon quantum dots to obtain the siRNA. Incubating at room temperature for 30 minutes to 1 hour to obtain a nano compound of the carbon quantum dots and the small nucleic acid; according to the invention, the drug stability and targeting effect can be improved.

The present application belongs to the technical field of packaging materials, and particularly relates to a peritoneal dialysis solution bag. The peritoneal dialysis solution bag comprises, from inside to outside, an inner layer, a heat preservation layer and an outer layer. The heat preservation layer is prepared from hollow fibers. The hollow fibers are obtained by spinning raw materials including chitosan, silk fibroin and hydroxyapatite. The prepared peritoneal dialysis solution bag has good heat preservation performance and barrier performance.

A system includes an apparatus configured to mix water, an acid / electrolyte concentrate, an osmotic concentrate, and a neutralizing buffer to produce a supply dialysate, a supply chamber configured to store the supply dialysate, a first filter that is configured to receive the supply dialysate from the supply chamber and to remove contaminants from the supply dialysate, a second filter, and one or more valves that: in a first configuration allow the second filter to receive a spent dialysate from the patient drain line to capture biological components from the spent dialysate such that the spent dialysate is dispensed via the system drain line, and in a second configuration allow the second filter to receive the supply dialysate to remove further contaminants from the supply dialysate such that the supply dialysate and the biological components are dispensed via the patient fill line.

This invention discloses a laboratory-grade ceramic membrane pressure filtration device, comprising a pressure ceramic membrane filtration unit, a pressure pump, a feed container, a valve, and a dialysate container. This invention uses an inorganic ceramic membrane as the filter medium, which is resistant to acids and alkalis, resistant to organic solvents, has a wide range of applications, high strength, and high operating pressure. It maintains high membrane integrity during installation, disassembly, and filtration, and offers high operating flux and high recovery rate. It can withstand both high-pressure steam sterilization and chemical sterilization. The sealing method is simpler than that of tubular ceramic membranes, and the dead volume is significantly smaller, requiring relatively less feed solution, making it suitable for laboratory operating environments.

The disclosure relates to a method including determining a treatment time of a dialysis treatment for a patient, receiving, from at least a sensor of a dialysis machine, a dialysate flow rate, the dialysate comprising bicarbonate pumped out of a bicarbonate source, wherein the bicarbonate source has an initial amount of bicarbonate, and predicting that by end of the dialysis treatment no more than a threshold amount of bicarbonate will be left in the bicarbonate source, and in response, determining that a clearance value during the treatment is or will be higher than the threshold clearance value, and sending, to a balancing system, an instruction to reduce the dialysate flow rate to a reduced rate, wherein the reduced rate results in reducing a rate of bicarbonate pumped out of the bicarbonate source while maintaining a clearance value of the treatment at no less than the threshold clearance value.

To provide a method for adjusting the dialysate flow rate and a hemodialysis apparatus that can quickly adjust the dialysate flow rate to a desired flow rate. [Solution] The method for adjusting the dialysate flow rate 100 includes: a pump control value determination step in which a pump control value corresponding to a desired dialysate flow rate is determined based on a calibration value that shows the correlation between a desired dialysate flow rate and the pump control value of the circulation pump 92; a pump operation step in which the circulation pump is operated with the pump control value determined in the pump control value determination step; a difference calculation step in which the difference between the current dialysate flow rate and the desired dialysate flow rate is calculated; and a calibration value correction step in which the calibration value is corrected based on the difference calculated in the difference calculation step.

A method includes receiving, by a processor of a dialysis machine, a dialysate flow rate, a bicarbonate setting value, a signal from a pressure sensor configured to measure a pressure within a container, and a signal indicating a state of a fill valve; determining, based on the signal received from the pressure sensor and the state of the fill valve, fill parameters; determining a volume of the container based on at least two of the fill parameters; determining a depletion time in which the concentrate will be depleted from the container based on the volume of the container, the dialysate flow rate, and the bicarbonate setting value; determining, based on the depletion time, an amount of time remaining before the concentrate will be depleted from the container; and causing the dialysis machine to indicate the amount of time remaining before the concentrate will be depleted from the container.

This disclosure relates to sorbent bags that is used in the purification and regeneration of a dialysis solution. Each sorbent bag comprises a sorbent material in a reinforced plastic sealed portion with luer extensions and clamps to facilitate the inlet and outlet of the dialysate solution and to facilitate the mechanism of operation. Furthermore, each sorbent bag has recharge / reactivation line with luer and a vent line. The recharge / reactivation line with luer is located at the inlet line of the sorbent bag at its distal portion before a porous portion. While a vent line is located at the outlet line of the sorbent bag after a second porous portion. Each sorbent bag has shape that is gradually increased in diameter until a diameter “D” and then gradually decreased in diameter through the remaining length of the bag in the direction of the fluid flow.

The invention provides a pea protein isolate-folic acid covalent graft as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving pea protein isolate, and stirring and mixing with ascorbic acid and H2O2 to obtain a reaction system; stirring folic acid and the reaction system to react, and adjusting the pH value to 7-12 in the reaction process to obtain a mixed solution; dialyzing to obtain dialysate, freezing the dialysate, and freeze-drying to obtain the pea protein isolate-folic acid covalent graft. According to the invention, the pea protein isolate-folic acid covalent graft is prepared by adopting a free radical grafting method for the first time, covalent coupling is realized only through amino (-NH2) of pea protein isolate and carboxyl of folic acid, and the green chemistry concept is met. The pea protein isolate-folic acid covalent graft has excellent storage stability, ultraviolet tolerance and thermal stability, and a novel carrier with comprehensive performance and definite application potential is provided for drug targeted colitis delivery.

The invention relates to the technical field of biological medicine, in particular to honeysuckle flower refined polysaccharide with antibacterial and anti-biofilm activity as well as a preparation method and application of the honeysuckle flower refined polysaccharide. Honeysuckle flowers and ultrapure water are mixed, decocted, concentrated and centrifuged, and supernate is obtained and serves as an extracting solution; adding absolute ethyl alcohol into the extracting solution, standing, precipitating, centrifuging, washing, and drying under reduced pressure to obtain a polysaccharide crude extract; dissolving the crude extract, adding a mixed solution of chloroform and n-butyl alcohol, vigorously oscillating and centrifuging to remove protein, and collecting an upper water phase to obtain a polysaccharide solution; placing the solution in a dialysis bag, and dialyzing with ultrapure water; and pre-freezing the dialysate, and performing vacuum freeze drying to obtain fine powder honeysuckle flower refined polysaccharide. The prepared honeysuckle flower refined polysaccharide has obvious bacteriostatic activity on pseudomonas aeruginosa, and can effectively inhibit the formation of a biofilm and remove a formed mature biofilm at a sub-inhibitory concentration. And a material basis is provided for developing novel antibacterial and anti-biofilm drugs and functional products.

The present invention aims to provide a dialysis apparatus with optimized placement and operability of the monitor unit. Furthermore, the present invention aims to provide a dialysis apparatus that reduces the burden on technicians in attaching blood circuits. [Solution] The dialysis apparatus comprises a housing 1 consisting of an electrical unit and a dialysate unit, a blood circuit connected to the patient through which blood and dialysate flow, an extracorporeal circulation unit 8 located on the front of the housing 1 and connected to the blood circuit, a dialyzer 2 located on the side of the housing, and a monitor unit 3 for operating each function and understanding the treatment status. Furthermore, the monitoring unit 3 is characterized by being positioned on the upper surface of the extracorporeal circulation unit as a deployable lid.

The present teachings generally include devices, systems, methods, and kits featuring safeguards to prevent the accidental reuse of effluent-filled bags as a source of fresh dialysis solution in peritoneal dialysis systems. This may include, for example, bags with chemical sensors that react with effluent contents to trigger visual indicators that alert a user to the bag being unsuitable for (re) use as dialysis solution. The present teachings may also or instead include bags engaged with connectors that mechanically alter and / or permanently couple during a dialysis treatment to prevent recoupling of the bags to supply tubing in the system, and / or techniques to ensure proper use of dialysis bags throughout a treatment cycle. These features can be useful for enhancing patient safety, particularly for users with cognitive impairments or in settings with limited oversight, e.g., by providing clear visual cues and / or physical barriers preventing potentially harmful misuse of dialysis bags.

The utility model relates to dialysate filtration technical field especially, relate to a medical dialysate filter device. The utility model provides a medical dialysate filter device that can realize the convenient first collecting frame and second collecting frame loading and unloading simultaneously and is convenient for firm installation, avoids accidental drop. A kind of medical dialysate filter device, including filter, mounting bracket and first collecting frame etc., mounting bracket is connected in filter middle part, and first collecting frame is placed in mounting bracket right part. The utility model places first collecting frame and second collecting frame in the left and right two parts of mounting bracket respectively, then loosens limit frame, torsion spring restores, so that first collecting frame and second collecting frame are all with limit frame clamping, then first connecting ring and second connecting ring are rotated 90 degrees, reach the effect that can realize the convenient first collecting frame and second collecting frame loading and unloading simultaneously and is convenient for firm installation, avoids accidental drop.

A renal failure blood therapy system includes a memory device storing a therapy target for a patient. The system also includes a processor configured to receive the therapy target for the patient, receive a desired solute concentration for the patient, and apply the therapy target and the desired solute concentration as inputs to an optimization routine. The processor is also configured to execute the optimization routine to determine at least one dialysis therapy prescription specifying at least a dialysis therapy duration, a dialysis therapy frequency, and at least one of a dialysis therapy blood flow rate or a dialysis therapy dialysate flow rate. The processor is further configured to display the at least one dialysis therapy prescription for confirmation or selection by a clinician and transmit the selected or confirmed dialysis therapy prescription to a dialysis machine for a subsequent dialysis treatment for the patient.

The invention discloses a cardiovascular complication risk prediction and dialysis method based on multi-dimensional data, which comprises a dialysate blending device, the dialysate blending device adds a potassium chloride solution into dialysate according to the blood potassium level of a patient to regulate and control the potassium ion concentration of the dialysate, and conveys the potassium ion concentration to a dialysis machine; the prediction and dialysis method comprises the following steps: firstly, collecting multi-dimensional data of a patient, and constructing a cardiovascular complication risk prediction model by utilizing big data analysis and machine learning technologies and combining the multi-dimensional data; predicting the possibility of cardiovascular events caused by blood potassium imbalance of the patient in a future period of time in advance; according to a prediction result, adjusting a dialysate potassium ion concentration strategy of the patient before dialysis; in the later treatment stage, the blood potassium level of the current patient is monitored, regulated and controlled, and individualized treatment is conducted according to the current blood potassium concentration. The potassium ion concentration strategy of the dialysate can be adjusted in advance, preventive treatment is implemented, and the treatment gate is moved forward.

A dialysis treatment system may use a dialysate filter for treating and cleaning dialysate. The dialysate filter may have a membrane where dialysate passes on a first side, and absorbent material is on the other side. The absorbent material may absorb urea, as well as other compounds from the dialysate. The absorbent material may supply various nutrients and compounds to the dialysate, and therefore act as a sink / source material for dialysate. The sink / source material may be a hydrogel or other protein-based material contained within a pressure-resistant housing. During the dialysis treatment, the pressure of the dialysate may be varied up and down, which increases the effectiveness of the sink / source material to clean and rejuvenate or regenerate the dialysate. The dialysis treatment system may intentionally vary the dialysis pressure during a treatment regime.

A sample solution preparation method, a measurement unit, a measurement kit, and a sample solution preparation device for measuring a target compound contained in a food by using a fluorescent immunoassay method. The features of the present disclosure include a dialysis step for bringing a target compound-containing solution including a target compound into contact with a dialysate through a dialysis membrane to transfer the target compound to the dialysate, wherein the molecular weight cut-off of the dialysis membrane is in the range of 2 x 10 2 to 2 x 10 5 , and the volume of the dialysate is relatively smaller than the volume of the target compound-containing solution.

A cyclo(His-Pro)(CHP) is useful for preventing, alleviating or treating peritoneal fibrosis. A pharmaceutical composition for preventing or treating peritoneal fibrosis, a dietary supplement composition for preventing or alleviating peritoneal fibrosis, and a peritoneal dialysis solution, which all contain CHP is disclosed. Also disclosed are a method for preventing or treating peritoneal fibrosis by using CHP, a peritoneal dialysis method using CHP, a use of CHP during the preparation of a pharmaceutical composition for preventing or treating peritoneal fibrosis, and / or a use of CHP in the preparation of a peritoneal dialysis solution.

The present disclosure sets forth a peritoneal dialysis ("PD") system, which allows the lowest operating ambient temperature of the PD fluid to be decreased without modifying the heater power or the flow rate during treatment. The system includes a PD machine or cycler. Fresh PD fluid is delivered via a single or dual lumen patient line to the patient and is first heated to a body fluid temperature, e.g., 37°C. Before fill, the PD fluid is preheated by pumping the fresh PD fluid from a solution bag, through the inline heater, into an empty solution bag, and back until the fresh PD fluid is heated to a pre-determined temperature. This allows the initial temperature of the fresh PD fluid in the solution bag to be lower.

The present application relates to hemodialysis prescription optimization technical field, especially in a kind of method and device for determining safe and effective prescription interval of hemodialysis.The method is in two-dimensional parameter space with ultrafiltration volume and dialysate sodium concentration as coordinate axis, using double-chamber sodium dynamics model (diffusion equilibrium concentration C_eq=[Na]d / σ (σ=0.97)) to calculate the sodium removal of each parameter combination and serum sodium after dialysis, superimpose sodium removal target line, ultrafiltration rate safety line and serum sodium safety area three constraint boundaries, the area that meets all constraints simultaneously is determined as safe and effective prescription interval.The safe and effective prescription interval is obtained by mathematical model calculation, not determined directly by preset empirical threshold.The present application first proposes the concept of safe and effective prescription interval, upgrades dialysis prescription from single-point empirical selection to interval optimization selection, and the constraint boundary can be dynamically adjusted according to individualized parameters of patients, to provide intuitive multi-constraint prescription decision support tool for clinicians.

The invention relates to the technical field of medical equipment, and particularly discloses a hemodialysis patient glucose metabolism management system based on real-time blood glucose monitoring, which comprises a real-time blood glucose monitoring module, a glucose metabolism data analysis module, an individualized treatment scheme generation module, an automatic intervention module, a data management and remote monitoring module, a safety and calibration module and the like. The real-time blood glucose monitoring module collects data through a high-precision sensor, and the data analysis module predicts the blood glucose trend through machine learning in combination with patient information and dialysis parameters. The scheme generation module generates insulin adjustment, dialysate optimization and nutrition suggestion schemes according to the insulin adjustment, dialysate optimization and nutrition suggestion schemes; the automatic intervention module executes the scheme and performs early warning; the data module stores uploaded data, and the security module guarantees accuracy and security. The blood glucose real-time monitoring and dynamic intervention are realized, the blood metabolism management effect of the hemodialysis patient is improved, the complication risk is reduced, and the clinical application value is high.