232 results about "Dialysis solutions" patented technology

A system for growing cells comprising a bioreactor chamber for growing the cells, a delivery system delivering a perfusion solution to the bioreactor chamber for perfusion of the perfusion solution through the cells, a dialysis system having a dialyzer, a dialysate for performing a dialysis and a filter for reducing ammonia content in said dialysate, and a controller that circulates the perfusion solution through the dialyzer and the dialysate through the filter.

The invention relates to medical instruments, in particular to a peritoneal dialysis device which comprises a dialysate management unit, a sensor unit, a processor, a storage device, a peritoneal transfer model, an intelligent alarm management unit and a communication unit, and the dialysate management unit is configured to be used for perfusion of dialysate into the abdominal cavity of a patient and drainage of the dialysate from the abdominal cavity of the patient; the sensor unit is configured to be used for monitoring physiological parameters of a patient and dialysate characteristic parameters and receiving symptom information and comfort level scores input by the patient, the storage stores instructions executed by the processor, and the instructions enable the processor to be capable of dynamically adjusting treatment parameters of the dialysate management unit in real time in combination with a pre-trained peritoneal transfer model. The perfusion speed, the drainage speed or the dialysate temperature of the dialysate management unit are dynamically adjusted, so that the comfort level score of the patient is maintained to be above a preset threshold value, treatment parameters can be dynamically adjusted in real time to optimize the treatment effect, peritonitis risks are early warned, and the comfort level of the patient is improved.

The invention provides a peritoneal dialysis solution detection data intelligent analysis method based on visual identification, and the method comprises the steps: obtaining a to-be-identified test paper image, carrying out the test paper region segmentation and color correction of the test paper image, and carrying out the brightness equalization processing of a test paper detection region, and obtaining a processed test paper detection region; obtaining a standardized color feature vector of a test paper color development area from the test paper detection area; carrying out mapping matching on the standardized color feature vector and a standard colorimetric database to obtain a colorimetric matching value, carrying out color abnormality identification according to the colorimetric matching value, comparing the color abnormality with a preset abnormal value to obtain a test paper colorimetric analysis result, and carrying out self-adaptive correction on the test paper colorimetric analysis result with abnormality; and constructing a personalized colorimetric model according to the colorimetric matching value in combination with a historical colorimetric matching value, and performing health trend analysis and early warning.

The invention discloses an MPSO-based dialysis solution preparation stirring parameter adaptive adjustment method, and relates to the technical field of dialysis solution preparation, and the method comprises the steps: initializing a digital twin model and a causal reasoning network, constructing a physical structure virtual mapping of a solution preparation device, calibrating parameters, and forming a calibrated virtual-real mapping decision support environment; on the basis of a virtual-real mapping decision support environment, multi-dimensional process data of historical prepared liquid batches are preprocessed, a causal discovery algorithm is adopted to update a causal reasoning network, a dialysis prepared liquid stirring parameter and prepared liquid quality causal relationship graph is learned, and a dynamically updated causal relationship network is established; and based on the dynamically updated causal relationship network, searching an optimal solution of a fitness function through particle swarm iteration, and generating a virtual environment pre-optimization parameter set. According to the method, key parameters such as the pump power, the turbulence angle and the stirring time can be adaptively searched and re-corrected under multiple working conditions through a particle swarm optimization mechanism based on MPSO in the dynamic virtual environment.

The disclosure relates to a method including determining a treatment time of a dialysis treatment for a patient, receiving, from at least a sensor of a dialysis machine, a dialysate flow rate, the dialysate comprising bicarbonate pumped out of a bicarbonate source, wherein the bicarbonate source has an initial amount of bicarbonate, and predicting that by end of the dialysis treatment no more than a threshold amount of bicarbonate will be left in the bicarbonate source, and in response, determining that a clearance value during the treatment is or will be higher than the threshold clearance value, and sending, to a balancing system, an instruction to reduce the dialysate flow rate to a reduced rate, wherein the reduced rate results in reducing a rate of bicarbonate pumped out of the bicarbonate source while maintaining a clearance value of the treatment at no less than the threshold clearance value.

The invention provides a printing and dyeing wastewater concentration method and system, and the method comprises the steps: carrying out pretreatment on desizing wastewater, so that suspended particles and colloidal impurities in the wastewater are intercepted and adsorbed by a filtering medium; carrying out buffering and flow regulation on the pretreated wastewater, and meanwhile, carrying out heat exchange on hot condensate water generated in the printing and dyeing production process and the pretreated wastewater; raising the temperature of the wastewater to 40 DEG C or above; pressurizing the heated wastewater and then carrying out membrane separation and concentration treatment, forming dialysate by micromolecular substances and part of water, and gradually accumulating intercepted macromolecular substances to form concentrated solution; when the concentration of the concentrated solution reaches the discharge standard, pollutants are treated by adopting a chemical precipitation method and a biological treatment method, or useful substances are recycled. The wastewater concentration process flow is optimized, the wastewater is filtered, intercepted and adsorbed through multiple media, a good water inlet condition is provided for concentration treatment, modified starch and PVA in the wastewater are effectively concentrated, and the follow-up treatment volume and difficulty are reduced.

The invention provides a process for preparing a high-purity human blood coagulation factor IX from plasma. The process comprises the following steps: acquiring plasma; adding anion gel, adsorbing, and collecting an eluted protein solution; adding heparin sodium, filtering, ultra-filtering and dialyzing to obtain dialyzed protein liquid; adding an S / D solution; adding anion gel for secondary adsorption, and collecting eluted protein liquid II; performing filtration, ultrafiltration and dialysis, and collecting eluted protein liquid after dialysis; filtering is performed; carrying out affinity gel chromatography purification, collecting eluent, and carrying out ultrafiltration and dialysis; filtering, and adding a dialysate containing glycine for dialysis to obtain a human blood coagulation factor IX stock solution; adjusting the titer, and adding heparin sodium to obtain a diluted solution; pre-filtering the diluted liquid to obtain a semi-finished product of the human blood coagulation factor IX; sterilizing, filtering, sub-packaging, carrying out vacuum freeze drying, carrying out dry heat virus inactivation, inspecting and packaging. According to the invention, the production process is simplified, the cost is reduced, the activity of the finally obtained human blood coagulation factor IX is greater than 50IU / ml, and the specific activity is higher than 180IU / mg.

The invention provides a test strip for identifying gram-negative bacteria in a peritoneal dialysis solution and a preparation method, and relates to the technical field of test strips. The test strip comprises a bottom plate as well as a sample pad, a combination pad, a coating pad and a water absorption pad which are sequentially arranged on the bottom plate, wherein a polydopamine coated colloidal gold coupled antibiotic probe is sprayed on the combination pad; a detection line is arranged on the coating pad, and the detection line is formed by hydrogel coated with antibiotics. According to the non-antibody-dependent immunochromatography test paper for detecting the gram-negative bacteria in the peritoneal dialysis solution, provided by the invention, a marker is simple and convenient to prepare, the use of paired antibodies is avoided, and the cost of the test paper is further reduced; moreover, time is gained for clinical diagnosis of microbial pathogens in dialysate, and correspondingly, antibiotic treatment is carried out on a patient in time. Each detection process can be completed within 10 min, the detection result is accurate, and the gram-negative bacteria in a peritoneal dialysis solution sample can be rapidly detected.

To provide a peritoneal function evaluation marker, peritoneal function evaluation kit, and peritoneal dialysis drainage measurement method that can measure D / P Cr or D / D0 Glu by a PET or an amount of drainage by a peritoneal dialysis upon implementing an ordinary peritoneal dialysis, by a simple method, and by a simple index, or can evaluate a peritoneal function equaling to a measurement of dip Na, and what is more, can take an appropriate action to prolong a peritoneal dialysis period as long as possible, and can contribute to improvement in quality of life of a patient, and an extention of the peritoneal dialysis period and life expectancy period, and improvement in medical economy.SOLUTION: A peritoneal function evaluation marker is composed of autotaxin. A peritoneal function evaluation kit includes a reagent that detects the peritoneal function evaluation marker composed of the autotaxin. A peritoneal dialysis drainage measurement method is configured to detect the peritoneal function evaluation marker composed of the autotaxin in peritoneal dialysis drainage.SELECTED DRAWING: None

The invention relates to the technical field of hemodialysis, in particular to a citric acid dialysis concentrated solution and a preparation method thereof. The anticoagulant factor X antibody is provided for the first time and is applied to preparation of the citric acid dialysis concentrated solution, result analysis shows that after the anticoagulant factor X antibody and the citric acid dialysis concentrated solution are combined, a synergistic effect is achieved on the anticoagulant effect of peripheral blood, the anticoagulant effect is extremely remarkable, and the application prospect of the citric acid dialysis solution can be remarkably improved.

The invention discloses a movable assistor for peritoneal dialysis, and relates to the technical field of peritoneal dialysis. The movable assistor for peritoneal dialysis comprises a bottom plate, a fixing rod is fixedly arranged on the top face of the bottom plate, the outer wall of the fixing rod is slidably sleeved with a lifting sleeve, a plurality of self-locking wheels are fixedly arranged on the bottom face of the bottom plate, and a lifting mechanism, a dialysis mechanism, a placing mechanism and a fixing mechanism are arranged above the bottom plate. The dialysis mechanism has the technical effects that the dialysis mechanism is composed of the monitoring part and the control part, an automatic monitoring and intelligent control system for the dialysis process is formed, two tray scales of the monitoring part can monitor the weight change of a dialysate container in real time, and the weight information is transmitted to the control calculator through a second data line; the two intelligent flow monitoring valves are installed at the bottom of the connecting pipe and can monitor the flow of dialysate in real time and transmit data through the first data line, and the calculator is controlled to analyze and process the received weight and flow information.

The utility model belongs to the technical field of dialysis machine pipeline anti-folding devices, and particularly relates to a dialysis machine pipeline anti-folding device which comprises a pipeline clamping frame and a first elastic buckle which are arranged on a dialysis machine body, a containing assembly is arranged at the top end of the pipeline clamping frame and internally comprises a first arc-shaped clamping plate, the first arc-shaped clamping plate is connected with a second arc-shaped clamping plate in a clamped mode, and the second arc-shaped clamping plate is connected with a second elastic buckle. The second arc-shaped clamping plate is arranged in the limiting assembly, the limiting assembly is arranged above the containing assembly, and the problems that when a patient moves, a pipeline is folded, dialysis fluid flowing is blocked due to folding of the pipeline, the dialysis treatment effect is affected, and more seriously, the dialysis treatment effect is affected are solved. And the folding of the pipeline also can cause the safety problems of blood backflow, dialysate leakage and the like and endanger the life safety of the patient.

The invention provides a nano-phase penthorum chinense pursh extract, which is prepared by the following steps: soaking a penthorum chinense pursh medicinal material, decocting, filtering, collecting filtrate, carrying out layering centrifugation to remove precipitate, dialyzing supernate by adopting a dialysis bag with the molecular weight cutoff of 3.5 kDa, and freeze-drying dialysate to obtain the nano-phase penthorum chinense pursh extract. The invention further provides a preparation method and application of the nanometer phase-state penthorum chinense pursh extract. The invention provides an extraction method capable of accurately separating 50-200nm phase-state active components in a nanometer phase-state penthorum chinense pursh extract traditional Chinese medicine. Organic solvents are prevented from being used, and the safety of extracted products is improved; the purity of the target component is improved; the structural integrity of a natural nanometer phase state is kept; the obtained nanometer phase-state extract has the effects of remarkably improving metabolic dysfunction related steatohepatitis and resisting coagulation, is high in separation efficiency, can be completed in 2-3 days, and can be applied on a large scale; the equipment is simple and low in cost.

The invention relates to the technical field, in particular to a dialysate supply system of a hemodialysis machine, which comprises a concentrated solution supply module, a dialysate mixing module, a concentration detection module, a data storage module, an intelligent control module and a centralized control module, the real-time state of a patient is dynamically analyzed through deep learning, components of dialysate are automatically adjusted, the crossing from a fixed formula to individualized dynamic supply is achieved, and the treatment effect is remarkably improved; secondly, the system can predict the risks of hypotension, hyperkalemia and the like prospectively, and actively intervene in advance, so that the incidence rate of dialysis-related acute complications is reduced; and moreover, the workload of medical staff for frequently and manually adjusting parameters is greatly reduced through automatic intelligent control, so that the medical staff can concentrate on clinical decisions, and medical resource allocation is optimized.

The invention discloses aztreonam microspheres as well as a preparation method and application thereof. The microsphere is an inhalation preparation and can be effectively deposited in the lung, so that the slow release of the medicine is realized. According to the aztreonam microspheres, aztreonam and cinnamyl aldehyde are synthesized into a small molecule drug, and the small molecule drug is self-assembled into the microspheres. The preparation method comprises the following steps: (1) placing aztreonam AZT and cinnamyl aldehyde CA in a glass bottle according to a molar ratio of 3: 2, adding dimethyl sulfoxide DMSO, stirring and dissolving, and stirring and reacting at room temperature for 5-7 hours; (2) dialyzing the reacted solution in a dialysis bag, removing DMSO and unreacted small molecules, and obtaining dialysate after 48 hours; (3) performing freeze drying to obtain yellow powder of cinnamyl aldehyde-aztreonam CAT; and (4) weighing the CAT powder, dissolving the CAT powder in deionized water, and shaking to dissolve the CAT powder to obtain the aztreonam microspheres. The microspheres are suitable for treatment of pulmonary infections, in particular for local drug delivery and sustained release control.

The invention relates to the technical field of peritoneal dialysis monitoring, and discloses a dynamic weighing and data fusion peritoneal dialysis solution balance monitoring system and method. The system comprises a dynamic weighing module, a multi-source data acquisition module, a data fusion processing module, a balance monitoring module and an early warning output module. The dynamic weighing module collects dialysate input and discharge amount in real time and generates weight data; the multi-source data acquisition module is used for acquiring dialysate components, treatment time and physiological parameters of a patient; the data fusion processing module is used for fusing the data to generate dialysate balance characteristic data; the balance monitoring module is used for calculating the net ultrafiltration amount and the liquid balance state and identifying the risk of abnormal leakage or liquid retention; and the early warning output module generates early warning information when the risk is identified. The system does not need manual intervention, can collect and fuse multi-source data in real time, accurately judge the liquid balance state and give an early warning in time, and is suitable for hospital and home peritoneal dialysis scenes.

The present disclosure relates to a functionalized polymer for use in a hemodialysis treatment for the extraction of at least one metal cation, the metal being iron, in a subject in need thereof, wherein said functionalized polymer has a weight average molecular mass between 100 kDa and 1000 kDa, and wherein a part of the monomeric units are functionalized with a chelating moiety, and is present in the dialysate of the hemodialysis treatment, the concentration of said chelating moiety in the dialysate being less than 0.35 mM, preferably between 0.0035 mM and 0.315 mM.

The utility model discloses a ceramic membrane filtration system for preparing ergothioneine, which comprises a fermentation tank, a circulating pump, a filter, a first ceramic membrane filtration assembly and a second ceramic membrane filtration assembly, the outlet of the fermentation tank is connected with the input end of the circulating pump, the output end of the circulating pump is connected with the filter, and the first ceramic membrane filtration assembly is connected with the second ceramic membrane filtration assembly. The filter is connected with an inlet of the first ceramic membrane filtration assembly, the first ceramic membrane filtration assembly and the second ceramic membrane filtration assembly are respectively provided with a dialysate outlet and a concentrated solution outlet, and an inlet of the second ceramic membrane filtration assembly is connected with the concentrated solution outlet of the first ceramic membrane filtration assembly. And a dialysate outlet of the second ceramic membrane filtering assembly is connected with an inlet of the first ceramic membrane filtering assembly. According to the ergothioneine extraction device, ergothioneine in fermentation liquor can be fully obtained, and the yield of ergothioneine is improved.

A method for incorporating at least one organic compound within a hydrogel, wherein the incorporation is carried out by dialysis, the organic compound being solubilized in the dialysis solution at a concentration equal to or greater than the target concentration.

The invention belongs to the technical field of hemodialysis concentrated solution production, and particularly relates to a hemodialysis concentrated solution preparing and mixing device which comprises a bottom plate and further comprises two supporting legs, the number of the supporting legs is two, and the bottom ends of the two supporting legs are both fixedly installed at the top of the bottom plate; the bottom and the right end of the mixing cylinder are fixedly mounted on the two supporting legs respectively, and a feeding opening is formed in the top of the mixing cylinder; the stirring assembly is arranged in the mixing cylinder, and the stirring assembly is used for stirring and mixing the dialysate; the discharging assembly comprises a discharging pipe, an electric control valve, a filtering box and a filtering net, efficient mixing in the dialysate preparation process and filtering in the discharging process are achieved through a simple structure, the production quality of the dialysate is improved, meanwhile, the prepared dialysate can be subjected to split charging processing, the production cost is reduced, and the production efficiency is improved. And the processing efficiency of the dialysate is improved, and the practicability is high.

The utility model discloses a hemodialysis concentrated solution packaging bag, and relates to the technical field of hemodialysis packaging bags, the hemodialysis concentrated solution packaging bag comprises a vertical packaging bag, a bag body and a material nozzle, the top end of the bag body is provided with a bag opening, the material nozzle is in heat seal connection with the bag opening, the bag body is in heat seal connection with a handle, and the material nozzle is provided with an inner cover; the wrist ring comprises a wrist ring and a wrist ring, the wrist ring comprises an inner cover and an outer cover, the anti-mistaken-opening mechanism comprises an outer cover, a first moving groove and an elastic piece, the first moving groove is formed in the inner wall of the outer cover, and the outer side of the inner cover is movably connected with the inner wall of the first moving groove. The packaging bag is limited at the wrist position, the packaging bag is effectively prevented from falling on the ground, the mistaken opening prevention function is achieved through the mistaken opening prevention mechanism, the situation that the cover is accidentally opened due to mistaken touch or other reasons in the non-use state is effectively avoided, concentrated liquid is prevented from being polluted, and the quality of dialysate and the use safety are guaranteed.

The invention provides a preparation method of a glycosylated hemoglobin standard substance in a whole blood sample, and belongs to the technical field of biological sample measurement. According to the method, the problem that glycosylated hemoglobin in a sample is unstable during dialysis operation and the problem that a matrix of a prepared standard substance is inconsistent with a matrix of an actually measured sample are solved by utilizing a specific dialysis environment and dialysate. The mode of adjusting the total hemoglobin concentration in the sample and the technology of redissolving the standard substance by using fetal calf serum after freeze-drying solve the problems that after the standard substance is accurately assigned by using a reference method, the standard substance has no interchangeability with a clinical sample when being detected by using a clinical detection method, and the measurement results are inconsistent.

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

The invention relates to the field of functional nanometer materials and sound-sensitive agent preparations, in particular to a high-efficiency sound-sensitive agent ZnO (at) Ce6 (at) PEG based on zinc oxide nanoparticles and a preparation method thereof, and belongs to the technical field of functional inorganic nanometer materials. The preparation method comprises the following steps: weighing ZnO-OH nano powder and m PEG-NH2, mixing, and magnetically stirring for 12 hours; ce6, EDC and NHS are weighed at the same time and added into a DMSO solution to be magnetically stirred for 12 h, then the Ce6, the EDC and the NHS are mixed and magnetically stirred for 24 h, dialysate outside a dialysis bag is continuously replaced with ultrapure water and the dialysis bag for 3 days, centrifugation is conducted after dialysis is finished, supernate is removed, and sediment is dried; after the reaction is completed, a powdery ZnO (at) Ce6 (at) PEG sound-sensitive agent is obtained; the efficient sound-sensitive agent ZnO (at) Ce6 (at) PEG based on the zinc oxide nanoparticles, provided by the invention, has relatively good sound-sensitive performance and a good sonodynamic development prospect.

The utility model discloses a dialysis device, and relates to the technical field of medical instruments, and the dialysis device comprises a dialysis appliance and a magnetic mechanism. The dialysis appliance comprises a shell, a membrane bundle and a movable tube with multiple holes in the side wall, the membrane bundle is arranged in the shell, and the movable tube is arranged in the middle of the membrane bundle; the magnetic mechanism comprises a magnetic bead, a magnetic block and a power assembly, the magnetic bead is movably arranged in the moving pipe, the power assembly is connected with the magnetic block, and the power assembly drives the magnetic block to move, so that the magnetic bead can move in the moving pipe under the magnetic matching action of the magnetic block and the magnetic bead. According to the dialysis device, flowing stirring of the dialysate in the middle of the membrane bundle can be achieved, flowing of the dialysate in the middle of the membrane bundle is homogenized, and therefore the bias flow phenomenon is avoided, and the problem that the mass transfer rate between toxin and the dialysate is low due to slow flowing of the dialysate in the middle of the membrane bundle is solved.

The utility model relates to a peritoneal dialysis solution sample transport box, which comprises a box body, a thermal insulation layer, a refrigeration device and a sealing cover, the box body is provided with a containing cavity used for containing a peritoneal dialysis solution sample, and the thermal insulation layer wraps the outer wall of the box body and is used for blocking external high temperature. The refrigeration device is arranged in the containing cavity and comprises a shell, a power box, a semiconductor refrigeration sheet and a cooling fin, the shell is installed in the box body, the semiconductor refrigeration sheet and the cooling fin are connected with the power box through wires, an installation hole is formed in the top of the shell, and one side of the cooling fin is inserted into the installation hole and fixedly connected with the shell; the other side clings to the hot surface of the semiconductor chilling plate; the sealing cover is detachably connected with the box body and used for sealing the containing cavity. The temperature in the box body is reduced by utilizing the refrigerating device, so that the peritoneal dialysis solution sample is refrigerated, the deterioration time of the peritoneal dialysis solution sample is delayed, and the accuracy of a detection result is improved.

The invention provides a carbon quantum dot and small nucleic acid nanocomposite, which is formed by wrapping the outer layer of a positively charged carbon quantum dot with negatively charged siRNA through electrostatic interaction, the carbon quantum dot is a histidine-doped chitosan quantum dot or arginine-doped chitosan quantum dot, chitosan is dissolved in an acetic acid solution, and the small nucleic acid and the chitosan are mixed to form the nanocomposite. The preparation method comprises the following steps: continuously adding amino acid, stirring until the amino acid is dissolved, treating for 6-8 hours at the temperature of 100-180 DEG C to obtain a mixture, cooling the mixture to room temperature, centrifuging, passing through a filter membrane with the pore diameter of 0.22-0.45 mu m, dialyzing the obtained filtrate in ultrapure water for 8-12 hours by using a dialysis bag with the MWCO value of 800-1000Da, freeze-drying the residual dialysate in the dialysis bag to obtain carbon quantum dots, mixing the carbon quantum dots with free siRNA, and performing freeze-drying on the carbon quantum dots to obtain the siRNA. Incubating at room temperature for 30 minutes to 1 hour to obtain a nano compound of the carbon quantum dots and the small nucleic acid; according to the invention, the drug stability and targeting effect can be improved.

The present application belongs to the technical field of packaging materials, and particularly relates to a peritoneal dialysis solution bag. The peritoneal dialysis solution bag comprises, from inside to outside, an inner layer, a heat preservation layer and an outer layer. The heat preservation layer is prepared from hollow fibers. The hollow fibers are obtained by spinning raw materials including chitosan, silk fibroin and hydroxyapatite. The prepared peritoneal dialysis solution bag has good heat preservation performance and barrier performance.

The invention discloses a method for extracting and preparing D-calcium pantothenate from fermentation broth, and relates to the technical field of D-calcium pantothenate production.The method comprises the steps that a chitosan flocculant is added into the fermentation broth, standing and flocculation are conducted, then calcium oxide is added, kieselguhr is added, plate frame clear liquid is filtered through an ultrafiltration membrane, ultrafiltration membrane clear liquid is concentrated through a nanofiltration membrane, purified water is added for dialysis, and the D-calcium pantothenate is obtained; desalting the obtained dialysate in cation exchange resin, adding calcium hydroxide into the desalted solution to adjust the pH value, concentrating the obtained neutralized solution, adding ethanol into the concentrated solution, cooling and crystallizing, filtering by a centrifugal machine after cooling to obtain a crude product, and drying to obtain a finished product. And anion exchange resin with higher price is not used, so that the method is environment-friendly, and meanwhile, the production cost is saved.

A system includes an apparatus configured to mix water, an acid / electrolyte concentrate, an osmotic concentrate, and a neutralizing buffer to produce a supply dialysate, a supply chamber configured to store the supply dialysate, a first filter that is configured to receive the supply dialysate from the supply chamber and to remove contaminants from the supply dialysate, a second filter, and one or more valves that: in a first configuration allow the second filter to receive a spent dialysate from the patient drain line to capture biological components from the spent dialysate such that the spent dialysate is dispensed via the system drain line, and in a second configuration allow the second filter to receive the supply dialysate to remove further contaminants from the supply dialysate such that the supply dialysate and the biological components are dispensed via the patient fill line.