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39 results about "Kidney Replacement Therapy" patented technology
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[edit on Wikidata] Renal replacement therapy (RRT) is therapy that replaces the normal blood-filtering function of the kidneys. It is used when the kidneys are not working well, which is called renal failure and includes acute kidney injury and chronic kidney disease.
High convection home hemodialysis/hemofiltration and sorbent system
InactiveUS20050131332A1Easily set up sterile blood therapy systemImprove efficiencySemi-permeable membranesHaemofiltrationPositive pressureSorbent
A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.
Owner:BAXTER HEALTHCARE SA +1
Hemodialysis system having a flow path with a controlled compliant volume
ActiveUS20130199998A1Enhanced convective clearanceReduce riskSemi-permeable membranesSolvent extractionDialysis membranesHaemodialysis machine
Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
Owner:MOZARC MEDICAL US LLC
Modular hemodialysis system
ActiveUS20130213890A1Mechanical/radiation/invasive therapiesSolvent extractionDialysis membranesActivated carbon
Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
Owner:MOZARC MEDICAL US LLC
Wearable continuous renal replacement therapy device
A continuous renal replacement therapy (CRRT) device adapted to be worn on a portion of the body of a patient. The CRRT device is worn by the patient and operates on rechargeable batteries for more than 5 hours. Dialysate is used to remove impurities from the blood. The dialysate is recycled and refreshed by a filter section. Less than one liter of dialysate is required to circulate through the wearable CRRT device.
Owner:FRESENIUS MEDICAL CARE HLDG INC
Batch filtration system for preparation of sterile fluid for renal replacement therapy
InactiveUS7544300B2Solve insufficient capacityPrevent heat lossSolvent extractionSettling tanks feed/dischargeBlood treatmentsDialysis fluid
A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and / or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
Owner:NXSTAGE MEDICAL INC +1
Wearable continuous renal replacement therapy device
A continuous renal replacement therapy (CRRT) device adapted to be worn on a portion of the body of a patient. The CRRT device is worn by the patient and operates on rechargeable batteries for more than 5 hours dialysate is used to remove impurities from the blood. The dialysate is recycled and refreshed by a filter section. Less than one liter of dialysate is required to circulate through the wearable CRRT device.
Owner:FRESENIUS MEDICAL CARE HLDG INC
Hemodialysis system having a flow path with a controlled compliant volume
ActiveUS20160038666A1Improve clearanceReduce riskSemi-permeable membranesSolvent extractionDialysis membranesHematological test
Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
Owner:MOZARC MEDICAL US LLC
Multichannel infusion system for renal replacement therapy
InactiveUS20130150821A1Other blood circulation devicesDialysis systemsMeasurement deviceControl system
A multichannel infusion system for use with a hemofilter includes first and second measurement devices that measure the weight of a replacement fluid in a first receptacle and an ultrafiltrate in a second receptacle, a first pumping module configured to accept a first desired flow rate and deliver the replacement fluid from the first receptacle to the hemofilter at the accepted first desired flow rate, a second pumping module configured to accept a second desired flow rate and remove the ultrafiltrate from the hemofilter to the second receptacle at the accepted second desired flow rate, and a control system in communication with the first and second measurement units and the first and second pumping modules. The control system is configured to adjust the first and second desired flow rates based on the measurements made by the first and second measurement devices.
Owner:CAREFUSION 303 INC
Dual flow sorbent cartridge
Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
Owner:MOZARC MEDICAL US LLC
Cardiac rhythm management device and sensor-suite for the optimal control of ultrafiltration and renal replacement therapies
ActiveUS8246563B2ElectrotherapyMechanical/radiation/invasive therapiesUltrafiltrationOptimal control
A cardiorenal patient monitoring system comprising, either implanted or non-implanted device(s), remote peripheral device(s), computer network(s), host, and communication means between the device(s), computer network(s), and host. The preferred embodiment shows an advanced patient monitoring system for using an implanted cardiac device and a dialysis machine in renal therapy. In addition, the method of advanced patient monitoring is in conjunction with the advanced patient monitoring system is disclosed.
Owner:CARDIAC PACEMAKERS INC
Dialysis optimisation method
A method as well as an apparatus is disclosed for determining the efficiency of a currently performed kidney replacement therapy on the dialysis side making use of a dialysis machine which in a first step is operated in a hemodialysis or hemodiafiltration process and in a second step is sequentially changed over to a hemofiltration process or is changed over to a sequential mode in which merely a flow from the blood compartment via the semipermeable membrane to the dialysis fluid compartment of the dialyser is generated in which, according to a third step, a sensor for determining or measuring the concentration at least of uremic toxins in the saturated dialysate or ultra-filtrate which is connected downstream of a dialyser on the dialysis side outputs corresponding measuring signals that are representative of the current concentration at least of uremic toxins in the blood to a calculation or determination unit.
Owner:B BRAUN AVITUM
Therapies for chronic renal failure
InactiveUS7524817B2Preventing delaying needReduce frequencyOrganic active ingredientsPeptide/protein ingredientsChronic kidney failureOsteogenic proteins
Owner:MARIEL THERAPEUTICS
Intelligent decision-making and quality control system for continuous kidney replacement therapy
ActiveCN113744832ASolving problems with clinical experienceImproving capacity to manage patients with critically ill AKITherapiesMedical practises/guidelinesAlternative treatmentQuality control system
The invention relates to an intelligent decision-making and quality control system for continuous renal replacement therapy, which is characterized by comprising a CRRT clinical decision-making model, an MOVIE index tracking unit and a CRRT prescription adjusting unit. According to the method, the specific characteristic variables influencing the CRRT are obtained, the CRRT clinical decision-making model is established by adopting the artificial intelligence algorithm based on the characteristic variables, and the CRRT clinical decision-making model outputs the initial CRRT treatment scheme which is adaptive to the patient based on the data of the patient and has the curative effect according to the historical data. Therefore, the problem that the formulation of the conventional CRRT treatment scheme depends on clinical experience of doctors is solved, and the problem that the conventional CRRT treatment scheme is unchanged in the whole treatment process, so that the treatment effect is affected is also solved. In addition, the practical situations of shortage of doctors, uneven diagnosis and treatment levels, lack of confidence in CRRT application and the like can be relieved, and the ability of managing critical AKI patients is improved.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Medicament, containing effector of glutathione metabolism together with alpha-lipoic acid for use in kidney replacement therapy
The invention relates to a medicament containing an effector of the glutathione metabolism together with alpha -lipoic acid, its salts and / or prodrugs as a combined preparation for the simultaneous, separate or time-controlled treatment of a defective thiol-disulfide status in kidney replacement therapy and of clinical characteristics, which indicate a disorder of the thiol-disulfide status of immunocytes. The correction of a defective thiol metabolism is of fundamental importance as a basic therapy for treating a large number of diseases of different origin, in particular however in circumstances requiring an essential kidney replacement therapy.
Owner:SERUMWERK BERNBURG AG
Multifunctional treatment vehicle applied to continuous kidney replacement therapy
InactiveCN103735381AImprove the efficiency of alternative treatmentsSimple structureDiagnosticsSurgeryVehicle frameAlternative treatment
The invention relates to the technical field of medical apparatus and instruments, and discloses a multifunctional treatment vehicle applied to continuous kidney replacement therapy. The treatment vehicle comprises a rack strut, a treatment table board and a waste area baseboard, wherein a damping band brake universal wheel is arranged at the bottom of the rack strut, the waste area baseboard is arranged at the upper side of the damping band brake universal wheel, and liquid tanks are arranged at the left and right sides of the rack strut; the treatment table board is arranged at the top end of the rack strut, a plurality of drawers are overlapped in a sealed area between the treatment table board and the waste area baseboard, and a garbage can is placed in the waste area baseboard; and a guard bar A with a push handle is arranged at the front side of the treatment table board, and guide bars B with handles are arranged at the left and right sides of the treatment table board. The treatment vehicle is simple in structure, convenient to use, is capable of meeting the demand of storing a plurality of treatment consumables and liquid, and improving the efficiency of the continuous kidney replacement therapy.
Owner:CHENGDU QINGSHAN LIKANG PHARMA CO LTD
Hemodialysis Supply Box and Drain Cabinet for Continuous Renal Replacement Therapy
A wall-mounted hemodialysis supply box and drain cabinet for use in continuous renal replacement therapy is provided that comprises a corrosion-resistant enclosure defining an interior space having a forwardly facing opening with a hinged door, at least one water-supply valve, at least one variable height bag holder, a bottom wall with a drain, and a plurality of inclined inside walls configured to channel waste water and treatment fluids into the drain. A sprayer hose attachment for use in washing down and cleaning the interior space is also disclosed.
Owner:HKS INC
Fluid extraction or filtration device, associated materials and methods
A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.
Owner:RENEPHRA
Kidney replacement therapy starting strategy evaluation method and device and electronic equipment
The invention provides a kidney replacement therapy starting strategy evaluation method and device and electronic equipment, and relates to the technical field of machine learning. The method comprises the following steps: based on patient data, determining a life state prediction result of a patient by adopting a life state monitoring model; and inputting the life state prediction result into a kidney replacement therapy RRT starting strategy evaluation model to obtain an RRT starting strategy evaluation result output by the RRT starting strategy evaluation model, the evaluation result comprising indication information about whether to suggest starting of RRT. According to the method, whether the RRT is suggested to be started or not is determined by adopting the RRT starting strategy evaluation model according to the life state of a patient, so that the prediction accuracy and the prediction efficiency of the RRT starting opportunity are improved.
Owner:戴松世
Modular hemodialysis system
ActiveUS10857277B2Mechanical/radiation/invasive therapiesOther blood circulation devicesDialysis membranesActivated carbon
Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
Owner:MOZARC MEDICAL US LLC
Simulation training device for extracorporeal membrane oxygenation combined continuous kidney replacement therapy
InactiveCN114360352AShorten the training periodEasy to practiceEducational modelsHuman bodyExtracorporeal membrane oxygenation
The invention belongs to the technical field of teaching training equipment, and discloses a simulated training device for extracorporeal membrane oxygenation and continuous kidney replacement therapy. The system comprises a human body simulator which is internally provided with an elastic liquid storage bag and a damping device capable of reducing the flow rate of liquid; the connecting pipe suite comprises a plurality of connecting pipes arranged corresponding to ECMO and CRRT system pipelines, adapters are arranged at the joints of the connecting pipes and the ECMO or CRRT system equipment and the human body simulator, one ends of the adapters are detachably connected with the connecting pipes, and the other ends of the adapters are used for being connected with the corresponding ECMO or CRRT system equipment or the human body simulator; each adapter is provided with an indicating lamp, the connecting pipe is provided with a wire, and the connecting pipe is connected with the corresponding adapter so that the corresponding indicating lamps can be connected in series or in parallel through the wire. The power supply is used for supplying power to the indicator lamp; the training burden can be reduced, and the training effect is improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
Remote management method and system for CRRT and nutrition state linkage and storage medium
The invention relates to the technical field of medical informatization, in particular to a remote management method and system for CRRT and nutrition state linkage and a storage medium, and the method comprises the following steps: obtaining a physical sign index through a wearable device, and obtaining a continuous renal replacement therapy CRRT metabolism index and a laboratory index; training a machine learning model by using an Internet of Things cloud platform based on the physical sign indexes, the CRRT metabolism indexes and the laboratory indexes, and constructing a multi-parameter decision model for nutrition demand prediction, CRRT machine setting and nutrition risk early warning; and adjusting a CRRT machine and nutrition supply by using the mobile terminal according to the output of the multi-parameter decision model, and carrying out early warning on nutrition risks. According to the method, real-time vital signs, CRRT clearing data and laboratory indexes are dynamically integrated through a multi-parameter decision model, and accurate quantification and dynamic matching of nutritional requirements and CRRT prescriptions are achieved.
Owner:TIANJIN FIRST CENT HOSPITAL
Medical treatment devices, systems, and methods for patient treatment preparation and subsequent follow-up
The invention relates to a medical treatment device (1) comprising a stationary unit (1a) and a mobile unit (1b) that can be separated from the stationary unit (1a). The invention relates to a stationary unit (1a), which can be connected, for example, to a stationary or domestic water source (5) and / or can be connected, for example, to a stationary or domestic water outlet (13) by means of a discharge line (11) in order to discharge dialysis waste liquid, and which comprises a mixing device (19), which in turn is configured to prepare and / or heat dialysis liquid for treating a patient (P). The mobile unit (1b) is configured to treat the patient (P), in particular renal replacement treatment, where the mobile unit (1b) comprises at least one line selected from the group consisting of a dialysis fluid input line (31) to the patient, a dialysis waste fluid output line (32) from the patient, and a patient connection line (33) for connection to the patient, and / or comprising a connector for connecting the line to the mobile unit (1b). The stationary unit (1a) and the mobile unit (1b) each comprise a connection (27, 29) so as to be connectable in fluid communication with each other.
Owner:FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
Application of danshinolic acid components in preparing pharmaceutical preparations for improving dialysis rate and filtration rate of protein-bound uremic toxins
ActiveCN108498498AImprove efficiencyImprove hemodialysisOrganic active ingredientsUrinary disorderSalvianolic acid BFiltration
The invention discloses application of danshinolic acid components in preparing pharmaceutical preparations for improving the dialysis rate and filtration rate of protein-bound uremic toxins. The danshinolic acid components include danshinolic acid B, protocatechuic aldehyde, rosmarinic acid, other danshinolic acid monomer components, pharmaceutical preparations containing salviae miltiorrhizae, pharmaceutical preparations containing salviae miltiorrhizae and safflower, and medicine suits with different salviae miltiorrhizae and safflower compatibility proportions. Through screening of a lot of experiments, results show that salviae miltiorrhizae and safflower injections and the danshinolic acid components can remarkably improve the dialysis efficiency of the protein-bound uremic toxins, can remarkably improve the filtering efficiency of the protein-bound uremic toxins, can be developed into auxiliary medicine preparations of in-vitro kidney replacement therapy strategies such as kidney disease dialysis and blood filtering, and have good development and application prospects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury
PendingUS20200397870A1Shortening of cessationShorten the durationHydrolasesPeptide/protein ingredientsElevated creatinineAcute Renal Injury
The present disclosure relates to the use of alkaline phosphatases, and in particular improved alkaline phosphatases such as RecAP, for the prevention, treatment, cure, or amelioration of the symptoms of acute kidney injury caused, e.g., by sepsis. The application relates to methods of preserving renal function renal function, shortening the duration of renal replacement therapy, increasing the creatinine clearance, decreasing the risk of death in subjects with sepsis-associate acute kidney injury (SA-AKI) or at risk of SA-AKI.
Owner:AM PHARMA
Clay mineral for reducing inorganic phosphates, in particular in renal replacement therapy
ActiveUS9585913B2Reduce concentrationIncrease capacityPowder deliveryMetabolism disorderInorganic phosphateClay minerals
The invention relates to a clay mineral for use as an agent for reducing the concentration of inorganic phosphate in liquids, in particular in bodily fluids or dialysis liquids, in order to treat hyperphosphatemia, in particular in a renal replacement therapy, wherein before use, the clay mineral is thermally treated at a temperature between 400° C. and 800° C., preferably between 500° C. and 700° C., in particular preferably at 550° C., over a time period of 60 min to 240 min, preferably 90 min to 180 min, in particular preferably 120 min.
Owner:FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV
Virtual assistant / chatbot to improve clinical workflows for home renal replacement therapies
A virtual assistant / chatbot to improve clinical workflow for home renal replacement therapies is disclosed herein. A virtual assistant / chatbot includes a patient-facing user interface configured to enable a patient to engage in a virtual chat session by typing, speaking, or otherwise providing information regarding a patient request or issue related to their renal replacement therapy. The virtual assistant / chatbot also includes a backend server-based system configured to provide logic to respond to a patient's requests. The logic defines a sequence of questions and answers for resolving patient queries. The sequence of assistant / chatbot questions and patient answers may be configured in a node arrangement such that certain patient answers / requests lead to additional questions for additional information from a patient. The virtual assistant / chatbot is configured to answer patient requests automatically or determine if the patient request is to be immediately addressed by a clinician or later through a phone call, text, or email communication.
Owner:BAXTER INT INC +1
Liquid management and volume monitoring system for continuous kidney replacement treatment of critical patient
The invention discloses a liquid management and volume monitoring system for continuous kidney replacement therapy of critical patients, which comprises a volume monitoring module, a microcirculation monitoring module, a data processing core module, an intelligent regulation and control module and a man-machine interaction module which are in two-way communication connection through a data bus, and the data processing core module is a system control center; the volume monitoring module comprises a noninvasive blood volume detection unit and an individualized infusion regulation and control unit. Through closed-loop automatic adjustment of the contact force of the probe, constant contact pressure between the probe and the skin of a patient is ensured, and imaging distortion caused by abnormal pressure is avoided; meanwhile, through three-dimensional coordinate monitoring and displacement influence coefficient quantification of patient displacement, in combination with an invalid data filtering algorithm based on a convolutional neural network, invalid data generated by interference are automatically filtered, the invalid data recognition accuracy is improved, the reliability of microcirculation monitoring data and blood volume monitoring data is greatly improved, and clinical misjudgment is avoided.
Owner:ANHUI PROVINCIAL HOSPITAL
Application of flavonoid components to prepare pharmaceutical preparation for reducing enterogenous urotoxin or precursor molecules
InactiveCN109528745AReduce generationReduce contentOrganic active ingredientsUrinary disorderGossypetinAdditive ingredient
The invention discloses an application of flavonoid components to prepare a pharmaceutical preparation for reducing enterogenous urotoxin or precursor molecules. The flavonoid components comprise flavonoid monomer components of isoquercitrin, hyperin, myricetin, gossypetin and the like. Through massive test screening, results prove that the flavonoid monomer components of the isoquercitrin, the hyperin, the myricetin, the gossypetin and the like can notably reduce the synthesis of the enterogenous urotoxin, can notably reduce the content of the enterogenous urotoxin, can develop an auxiliary pharmaceutical preparation for in vitro kidney replacement therapy of nephropathy dialysis, blood filtration and the like, and has good development and application prospects.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Application of salvianolic acid components in the preparation of pharmaceutical preparations for improving the dialysis rate and filtration rate of protein-bound uremic toxins
ActiveCN108498498BImprove efficiencyImprove hemodialysisOrganic active ingredientsUrinary disorderNephrosisNephropathy
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury
PendingCN112261948ADuration shortened or stoppedHydrolasesPeptide/protein ingredientsAcute Renal InjurySubstitution therapy
Owner:AM PHARMA