Immunotherapeutic agent

a technology of immunotherapy and immunomodulatory agent, applied in the field of compounds, can solve the problems of sepsis remains a serious clinical problem, multiple organ failure and ultimately death, and achieve the effects of preventing organ damage that it produces, inhibiting proinflammatory signaling, and preventing sepsis developmen

Inactive Publication Date: 2018-07-05
UNIV OF COLORADO THE REGENTS OF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0017]The method of the fourth aspect can be used to inhibit proinflammatory signaling by activated macrophages and delay the development of sepsi

Problems solved by technology

During sepsis, the body's immune system is dysregulated as it tries to fight an infection, and this can reduce blood supply to vital organs such as the brain, heart and kidneys

Method used

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[0069]The fractionation of M. vaccae NCTC 11659 with a number of solvents resulted in the isolation of several lipid fractions with different characteristics. Preliminary work identified lipids present in the aqueous methanol fraction, such as phospholipids, polar and neutral glycolipids and glycosylphosphatidylinositols, but not those in the petrol fraction, such as phthiocerols, dimicocerosates and mycolic acids, to be of considerable interest.

[0070]Pretreatment with an Aqueous Methanol Extraction of M. vaccae Reduces Allergic Pulmonary Inflammation

[0071]Upon further fractionation of the aqueous methanol fraction, the phospholipid, polar glycolipid and glycosyl phosphatidylinositol components (fraction 147) were separated from the neutral glycolipid components (fraction 148).

[0072]In Experiment 1, the immunomodulatory properties of the two fractions were assessed in vitro using Thp1 cells, a human monocytic cell line, exposed overnight to these preparations (for experimental timel...

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Abstract

Compounds for use in the treatment of sepsis and/or the prevention or treatment of post-sepsis syndrome.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 62 / 440,353 filed Dec. 29, 2016, the disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention provides compounds for use in the treatment of sepsis and / or the prevention or treatment of post-sepsis syndrome.BACKGROUND OF THE INVENTION[0003]Sepsis, a potentially life-threatening condition triggered by an infection or injury, is the result of an overwhelming inflammatory host response to bacterial infection. During sepsis, the body's immune system is dysregulated as it tries to fight an infection, and this can reduce blood supply to vital organs such as the brain, heart and kidneys which can cause multiple organ failure and ultimately death.[0004]It had long been believed that sepsis merely represented an exaggerated, hyperinflammatory response that led to inflammation-induced organ injury, but recent data indic...

Claims

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Application Information

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IPC IPC(8): A61K31/201A61K31/231A61K9/00A61P31/00
CPCA61K31/201A61K31/231A61K9/0019A61P31/00
Inventor BRUNET, LAURA ROSALOWRY, CHRISTOPHER A.
Owner UNIV OF COLORADO THE REGENTS OF
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