Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Immunotherapeutic agent

a technology of immunotherapy and immunomodulatory agent, applied in the field of compounds, can solve the problems of sepsis remains a serious clinical problem, multiple organ failure and ultimately death, and achieve the effects of preventing organ damage that it produces, inhibiting proinflammatory signaling, and preventing sepsis developmen

Inactive Publication Date: 2018-07-05
UNIV OF COLORADO THE REGENTS OF
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is based on the discovery of certain compounds that can prevent the secretion of a proinflammatory cytokine from activated macrophages. These compounds can inhibit the proinflammatory cascade that contributes to the pathology of sepsis, and may therefore be useful in treating infections that result in sepsis while preventing damage to organs. The patent text describes methods for using these compounds to treat sepsis and delay its development.

Problems solved by technology

During sepsis, the body's immune system is dysregulated as it tries to fight an infection, and this can reduce blood supply to vital organs such as the brain, heart and kidneys which can cause multiple organ failure and ultimately death.
Despite intense efforts, sepsis remains a serious clinical problem despite improvements in critical care management.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Immunotherapeutic agent
  • Immunotherapeutic agent
  • Immunotherapeutic agent

Examples

Experimental program
Comparison scheme
Effect test

examples

[0069]The fractionation of M. vaccae NCTC 11659 with a number of solvents resulted in the isolation of several lipid fractions with different characteristics. Preliminary work identified lipids present in the aqueous methanol fraction, such as phospholipids, polar and neutral glycolipids and glycosylphosphatidylinositols, but not those in the petrol fraction, such as phthiocerols, dimicocerosates and mycolic acids, to be of considerable interest.

[0070]Pretreatment with an Aqueous Methanol Extraction of M. vaccae Reduces Allergic Pulmonary Inflammation

[0071]Upon further fractionation of the aqueous methanol fraction, the phospholipid, polar glycolipid and glycosyl phosphatidylinositol components (fraction 147) were separated from the neutral glycolipid components (fraction 148).

[0072]In Experiment 1, the immunomodulatory properties of the two fractions were assessed in vitro using Thp1 cells, a human monocytic cell line, exposed overnight to these preparations (for experimental timel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Compositionaaaaaaaaaa
Antimicrobial propertiesaaaaaaaaaa
Login to View More

Abstract

Compounds for use in the treatment of sepsis and / or the prevention or treatment of post-sepsis syndrome.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 62 / 440,353 filed Dec. 29, 2016, the disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention provides compounds for use in the treatment of sepsis and / or the prevention or treatment of post-sepsis syndrome.BACKGROUND OF THE INVENTION[0003]Sepsis, a potentially life-threatening condition triggered by an infection or injury, is the result of an overwhelming inflammatory host response to bacterial infection. During sepsis, the body's immune system is dysregulated as it tries to fight an infection, and this can reduce blood supply to vital organs such as the brain, heart and kidneys which can cause multiple organ failure and ultimately death.[0004]It had long been believed that sepsis merely represented an exaggerated, hyperinflammatory response that led to inflammation-induced organ injury, but recent data indic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/201A61K31/231A61K9/00A61P31/00
CPCA61K31/201A61K31/231A61K9/0019A61P31/00
Inventor BRUNET, LAURA ROSALOWRY, CHRISTOPHER A.
Owner UNIV OF COLORADO THE REGENTS OF
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com