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33 results about "Bioreductive Agent" patented technology
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Antitumor agents that are activated by biological reduction and have selective efficacy against hypoxic solid tumors. (NCI)
Method for treating chlorinated organic pollutants in underground water by using slow-release compound repair material
ActiveCN104876321AAchieving Synergistic Enhanced RestorationEfficient removalOther chemical processesBiological water/sewage treatmentMicrosphereSorbent
The invention discloses a method for treating chlorinated organic pollutants in underground water by using a slow-release compound repair material. The method comprises the following steps: (1), preparing charcoal through high temperature pyrolysis; (2), pre-treating zero-valent iron through acid pickling; (3), adding water into the charcoal, then adding xanthan gum and an organic carbon source, and finally, adding zero-valent iron, and through steps of treating, obtaining the slow-release compound repair material; then treating chlorinated organic pollutants in underground water by adopting an in situ injection repairing method or an in situ PRB repairing method. According to the method provided by the invention, the xanthan gum with high mechanical strength and strong mass transfer performance is used as a novel slow release embedding medium, the physical adsorbent charcoal, the chemical reductant zero-valent iron and the bioreductive drug organic carbon source are taken as effective components for composite embedding, so that gel microspheres with stable structures are formed, and the method provided by the invention has the advantages of sustained release, simple and convenient operation, low cost, environment friendliness and the like, can effectively achieve physically, chemically and biologically collaborated and enhanced remediation, and can effectively remove target pollutants.
Owner:SHANGHAI ACADEMY OF ENVIRONMENTAL SCIENCES
Method for preparing graphene simultaneously doped with nitrogen and sulfur through biological reduction
The invention provides a method for preparing graphene simultaneously doped with nitrogen and sulfur through biological reduction, and belongs to the technical fields of graphene synthesis and a nano material. The method is characterized in that oxidized graphene dispersion solution is used as a raw material, sulfate-containing reduction bacteria suspension is used as a biological reduction agent, the raw material is reacted with the biological reduction agent for 5 to 10 days in a control reaction system under an air insulation condition to obtain a graphene solution, and the graphene solution is centrifugally filtered and repeatedly washed to obtain graphene doped with nitrogen and sulfur. According to the method, no stabilizer or dispersing agent is added, and oxidized graphene is reduced by utilizing the metabolic activity of the microorganisms to obtain graphene doped with nitrogen and sulfur, so that the method has the advantages of safety, no toxicity, simplicity in operation, environmental friendliness and the like, the difficulty that nitrogen and sulfur cannot be simultaneously doped in the existing graphene preparation method can be solved, when graphene simultaneously doped with the nitrogen and sulfur is applied to the fields such as electrochemical sensors, electric catalysis and the like, the detection limit and the detection sensitivity can be remarkably improved, and the application prospect is promising.
Owner:HUAZHONG UNIV OF SCI & TECH +1
Induction of tumor hypoxia for cancer therapy
ActiveUS20120087913A1Improve anti-tumor activityReducing and minimizing side effectBiocidePeptide/protein ingredientsSide effectWhole body
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
Owner:VIRGINIA COMMONWEALTH UNIV
Compound solid mouth wash effervescent tablet and preparation method thereof
InactiveCN105982835ARelieve painReduce harmCosmetic preparationsToilet preparationsSodium bicarbonateChlorhexidine Acetate
The invention discloses a compound solid mouth wash effervescent tablet and a preparation method thereof. The effervescent tablet is prepared from honeysuckle extract, chlorhexidine acetate, mannitol, pregelatinized starch, sodium carboxymethyl starch, lactose, acesulfame, polyethylene glycol, L-cysteine, sodium bicarbonate, menthol, lauryl sodium sulfate, DL-tartaric acid and hydroxypropyl methylcellulose. The preparation method comprises the following steps: grinding and screening each raw material; uniformly mixing according to the proportion; and granulating, drying, grinding, mixing and tabletting. The effervescent tablet contains polyphenols, flavonoids, vitamins, amino acids and other multiple bio-reductive drugs, has the effects of diminishing inflammation and resisting allergy, can be used for effectively relieving development of ulcer, preventing or alleviating gingivitis to achieve the effect of strengthening teeth, can be used for killing dental bacteria, reducing injury of the dental bacteria on teeth and gum, effectively cleaning the oral cavity and reducing halitosis, and can indirectly improve the body immunity if being taken for a long time.
Owner:成都悟道科技有限公司
Slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater and preparation method thereof
ActiveCN104944568AAchieving Synergistic Enhanced RestorationEfficient removalOther chemical processesWater contaminantsSorbentMicrosphere
The invention discloses a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater and a preparation method thereof. The preparation method comprises the steps of (1) preparing biochar by high-temperature pyrolysis; (2) pretreating zero-valent iron by acid pickling; and (3) adding water into the biochar, adding xanthan gum and an organic carbon source, adding zero-valent iron finally, and carrying out multi-step treatment on the obtained mixture so as to obtain a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater. According to the invention, by using the xanthan gum with high mechanical strength and strong mass transfer performance as a novel slow-release embedding agent, the biochar (as a physical adsorbent), the zero-valent iron (as a chemical reductant) and the organic carbon source (as a biological reductant) which are taken as effective components are compositely embedded so as to form constitutionally stable gel microspheres, and the slow-release compound repair material has the advantages of long-term slow-release, easy operation, low cost, environment friendliness, and the like, and can effectively realize the physical, chemical and biological synergistic reinforced repair, therefore, the material can remove target pollutants more efficiently.
Owner:SHANGHAI ACADEMY OF ENVIRONMENTAL SCIENCES
In-situ process for detoxifying hexavalent chromium in soil and groundwater
Inexpensive, highly effective methods for the in-situ reduction of hexavalent chromium to the non-toxic trivalent oxidation state in soil and groundwater containing hexavalent chromium are provided, which may reduce hexavalent chromium concentration in soil to as low as 5 mg / L. The methods involve sampling soil comprising hexavalent chromium to determine a reaction amount of a reducing agent, providing a frame on a top surface of the soil, wetting the soil, spreading a reducing agent on the top surface of the soil, and flushing the soil with water to dissolve the reducing agent. The reducing agent may be a chemical agent, a biological agent, or a combination of chemical and biological agents. The biological reducing agents may include sludge from wastewater, return activated sludge, waste activated sludge, leachate from landfill or from composting operations, or compost material from municipal wastewater, industrial wastewater, or solid waste operations.
Owner:GANNETT FLEMING
Nano antibacterial hemp fibers and preparation method and application thereof
InactiveCN110055753AFlat surfaceGood dispersionBiochemical fibre treatmentVegetal fibresSilver particlesReducing agent
The invention relates to the technical field of hemp antibacterial materials, and discloses nano antibacterial hemp fibers and a preparation method and application thereof. The nano antibacterial hempfibers are obtained by soaking hemp fibers in a silver ion solution and reacting the hemp fibers with an industrial hemp flower and leaf plant extracting solution. According to the method, the silverion solution is used as a silver source precursor, the plant extracting solution is used as a biological reducing agent, silver ions are reduced in situ by using the industrial hemp flower leaf plantextracting solution after the hemp fibers adsorb the silver ions, nano silver particles grow on the surfaces or insides of the fibers, and the reacted nano antibacterial hemp fibers have high-efficiency, fast and durable antibacterial performance and washing resistance.
Owner:INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
Induction of tumor hypoxia for cancer therapy
ActiveUS8591921B2Improve anti-tumor activityReducing and minimizing side effectBiocidePeptide/protein ingredientsIntracellularOncology
Owner:VIRGINIA COMMONWEALTH UNIV
Preparation and applications of medicinal composition of NO-donating titanium dioxide derivative
ActiveCN106362147AGood biocompatibilityStrong targetingOrganic active ingredientsInorganic non-active ingredientsSide effectBiocompatibility Testing
The invention relates to preparation and applications of a medicinal composition of a NO-donating titanium dioxide derivative, for effectively realizing the treatment medication aiming at tumor, and realizing the diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation comprises the following steps: reacting hollow mesoporous titanium dioxide nano particles and mercaptopropyl triethoxysilane to obtain a sulfhydryl hollow mesoporous titanium dioxide compound, reacting the sulfhydryl hollow mesoporous titanium dioxide compound with tert-butyl nitrite to obtain the NO-donating titanium dioxide derivative, and finally, loading an antitumor drug such as a bioreductive agent. The preparation and applications have the advantages that the operation is convenient, the method is stable and reliable, the prepared NO-donating titanium dioxide and the medicinal composition of the NO-donating titanium dioxide have the advantages that the biocompatibility is good, the targeting ability is strong, the toxic and side effects are small, etc., in the aspect of tumor treatment, the ultrasonic therapy of TiO2, the anti-tumor therapy effect of NO, and the lethal effect of the bioreductive agent can be exerted, meanwhile, the early-stage diagnosis and later-stage treatment can be integrated by utilizing the ultrasonic imaging property of the generated NO gas, and therefore, the technical scheme belongs to an innovation in the tumor treatment medicines.
Owner:ZHONGSHUAI PHARMA SCI & TECH CO LTD
Methods for treating liver tissue
InactiveUS20190083501A1Reduce pressureBalloon catheterSurgical adhesivesLiver tissueDecreased mean arterial pressure
Methods and kits are provided for administering a hypoxia-activated bioreductive agent by applying the agent locally to liver tissue when hepatic arterial pressure is reduced. Local arterial application when pressure is reduced tissue prolongs the duration of tissue exposure to the hypoxia-activated bioreductive agent. Hepatic pressure may be reduced proximal to the liver tissue. In some embodiments, local application may be followed by embolization when arterial pressure is reduced. Embolization under reduced pressure may decrease complications associated with backflow and increase the efficacy of the hypoxia-activated agent.
Owner:TECLISON LTD
Dyeing technology without sewage discharging for jean
The invention belongs to the technical field of cloth dyeing and particularly relates to dyeing technology without sewage discharging for jean. The dyeing technology mainly includes that indigo, a biological reducing agent, diffusant and water are mixed to obtain dye, control of yarn humidity and dyeing process temperature is combined, finally jean yarn dyed by the indigo is obtained, and the jean yarn is spun to obtain jean products. Compared with traditional technology, the dyeing technology saves repeated dyeing-oxidization procedures, especially, dyed yarn does not need to be washed with a large amount of water, and the dyeing technology not only saves a large amount of energy, simultaneously greatly reduces damage of sewage on environment, and has remarkable social benefit and economical benefit.
Owner:孙国祥 +2
Hexavalent chromium repairing agent and application and using method thereof
InactiveCN109097060ARestoring Planting FunctionWide variety of sourcesOther chemical processesContaminated soil reclamationSoil remediationPollution
The invention discloses a hexavalent chromium repairing agent and an application and a using method thereof, and belongs to the technical field of contaminated soil remediation. The hexavalent chromium repairing agent is mainly composed of a chemical reducing agent, a biological reducing agent and a biomass stabilizer, wherein the chemical reducing agent is 1-5% of the soil weight, the biologicalreducing agent is 2-5% of the soil weight, and the biomass stabilizer is 2-5% of the soil weight. The agent has high reduction efficiency, long-term stability of repairing effects and low compoundingcost, and is a repairing agent capable of achieving long-term stable effect on hexavalent chromium. A using method of the repairing agent for repairing hexavalent chromium soil pollution is further provided. The chemical reducing agent, the biological reducing agent and the biomass stabilizer are creatively combined. The pH of the soil is maintained within the neutral to alkaline range by means ofthe acid-base neutralization effect of the agent and the acid-base buffering capability of a soil system, and an acid-base regulating agent is saved.
Owner:BEIJING GEOENVIRON ENG & TECH
Manganese-based magnetic resonance contrast agents
ActiveUS20150336997A1High resolutionSlower tumbling of the moleculesRadioactive preparation carriersNMR/MRI constrast preparationsOxidation stateManganese
Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.
Owner:THE GENERAL HOSPITAL CORP
Conjugate of Biomacromolecule with Bioreductive and Preparative Method Thereof
InactiveUS20080306248A1Improve anti-tumor effectInhibit growthPeptide/protein ingredientsTransferrinsNitro compoundQuinone
Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided. The biomacromolecule is selected from apo-transferrin, Fe-transferrin, Ru-transferrin, Ti-transferrin, Ga-transferrin, Pt-transferrin, somatostatin, EGF, folacin acid or transcobalamin, and the bioreductive agent is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal compound. Such conjugate can selectively target the tumor cells, and lower the toxicity of medicines and survivability of tumor cells, so that the conjugate can be used for delivery of anti-tumor compounds or treating tumors.
Owner:NANJING UNIV
Composition of transiron protein and biological reducing agent and its preparation method
InactiveCN1686562ALow toxicityReduced tolerancePeptide/protein ingredientsNitro compound active ingredientsNitro compoundQuinone
A compound of the active anticancer protein and bioreducer for preparing the medicine to treat cancer is prepared from the target protein chosen from transferrin, ceruloplasmin, somatostatin, vitamine bindin, etc and the bioreducer chosen from bifunctional heterocyclic nitro compound, quinone, heterocyclic NOx, topoisomerase B inhibitor and DNA-targeting medicine.
Owner:NANJING UNIV
Anti-oxidation tooth-strengthening tablet and preparation method thereof
InactiveCN105982943ARelieve painReduce harmHydroxy compound active ingredientsDigestive systemChlorhexidine AcetatePolyethylene glycol
The invention discloses an anti-oxidation tooth-strengthening tablet and a preparation method thereof. The tablet is prepared from bioactive glass, honeysuckle extract, strontium chloride, sodium fluoride, potassium nitrate, chlorhexidine acetate, ground calcium carbonate, mannitol, pregelatinized starch, sodium carboxymethyl starch, acesulfame, polyethylene glycol, mentholand lauryl sodium sulfate. The preparation method comprises the following steps: respectively grinding each raw material, screening, and uniformly mixing; adding ethanol to granulate, drying, grinding into powder, and mixing; and tabletting after uniform mixing. The tooth-strengthening tablet contains polyphenols, flavones, vitamins, amino acids and other multiple bio-reductive drugs, and has the effects of diminishing inflammation, resisting allergy, resisting ulcer, preventing or alleviating gingivitis to strength teeth. The anti-oxidation tooth-strengthening tablet can be used for filling deficiency in the tooth enamel surface, reducing tooth sensitivity, removing stains on the surface, reducing generation of dental calculus, killing oral bacteria, reducing injury of oral bacteria on teeth and gum, effectively cleaning the oral cavity and relieving halitosis, and can be used for indirectly improving body immunity when being used for a long time.
Owner:成都悟道科技有限公司
A method for treating chlorine-containing organic pollutants in groundwater with slow-release composite restoration materials
ActiveCN104876321BAchieving Synergistic Enhanced RestorationEfficient removalOther chemical processesBiological water/sewage treatmentMicrosphereSorbent
The invention discloses a method for treating chlorinated organic pollutants in underground water by using a slow-release compound repair material. The method comprises the following steps: (1), preparing charcoal through high temperature pyrolysis; (2), pre-treating zero-valent iron through acid pickling; (3), adding water into the charcoal, then adding xanthan gum and an organic carbon source, and finally, adding zero-valent iron, and through steps of treating, obtaining the slow-release compound repair material; then treating chlorinated organic pollutants in underground water by adopting an in situ injection repairing method or an in situ PRB repairing method. According to the method provided by the invention, the xanthan gum with high mechanical strength and strong mass transfer performance is used as a novel slow release embedding medium, the physical adsorbent charcoal, the chemical reductant zero-valent iron and the bioreductive drug organic carbon source are taken as effective components for composite embedding, so that gel microspheres with stable structures are formed, and the method provided by the invention has the advantages of sustained release, simple and convenient operation, low cost, environment friendliness and the like, can effectively achieve physically, chemically and biologically collaborated and enhanced remediation, and can effectively remove target pollutants.
Owner:SHANGHAI ACADEMY OF ENVIRONMENTAL SCIENCES
Method for preparing TiO2 nanotubes (TNTs) based composite through biological method
ActiveCN108588130AHigh catalytic efficiencyEasy to solveMicroorganism based processesFermentationTio2 nanotubeReagent
The invention discloses a method for preparing TiO2 nanotubes (TNTs) based composite through a biological method. Through the steps of preparation of an LB culture medium, preparation of an anaerobicculture medium, inoculation and cultivating of an MR-1 strain, synthesis of TiO2 nanotubes (TNTs), preparation of a mother solution, preparation of the TNTs based composite and the like, Ag2S NPs is synthesized in situ on the tube walls of the TNTs with microorganism Shewanella oneidensis MR-1 taken from the environment as a biological reduction agent and a template agent, and accordingly the Ag2S / TNTs based composite is further formed. The method is economic and effective, and has low-carbon and environment-friendly effects, adding of chemical reagents is avoided, and no energy is consumed; and meanwhile the Ag2S / TNTs based composite produced through the method is used for catalytic reduction of organic pollutant paranitrophenol which is difficult to degrade and has biotoxicity in the environment, and is high in catalysis efficiency.
Owner:ANHUI UNIVERSITY
A slow-release composite restoration material for treating chlorine-containing organic pollutants in groundwater and its preparation method
ActiveCN104944568BAchieving Synergistic Enhanced RestorationEfficient removalOther chemical processesWater contaminantsMicrosphereSorbent
The invention discloses a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater and a preparation method thereof. The preparation method comprises the steps of (1) preparing biochar by high-temperature pyrolysis; (2) pretreating zero-valent iron by acid pickling; and (3) adding water into the biochar, adding xanthan gum and an organic carbon source, adding zero-valent iron finally, and carrying out multi-step treatment on the obtained mixture so as to obtain a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater. According to the invention, by using the xanthan gum with high mechanical strength and strong mass transfer performance as a novel slow-release embedding agent, the biochar (as a physical adsorbent), the zero-valent iron (as a chemical reductant) and the organic carbon source (as a biological reductant) which are taken as effective components are compositely embedded so as to form constitutionally stable gel microspheres, and the slow-release compound repair material has the advantages of long-term slow-release, easy operation, low cost, environment friendliness, and the like, and can effectively realize the physical, chemical and biological synergistic reinforced repair, therefore, the material can remove target pollutants more efficiently.
Owner:SHANGHAI ACADEMY OF ENVIRONMENTAL SCIENCES
Manganese-based magnetic resonance contrast agents
ActiveUS9944668B2High resolutionSlower tumbling of the moleculesRadioactive preparation carriersNMR/MRI constrast preparationsOxidation stateManganese
Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.
Owner:THE GENERAL HOSPITAL CORP
Nanocomposite with nucleus-shell structure based on biological method and preparation method of nanocomposite
ActiveCN110368998ASelf-dopingEnhanced mass transferOrganic-compounds/hydrides/coordination-complexes catalystsNanoparticleThermal stability
The invention discloses a nanocomposite with a nucleus-shell structure nanocomposite based on a biological method and a preparation method of the nanocomposite. According to the nanocomposite, firstlyan amino acid modified by a complexing agent used as a biological soft template to derive an active oxide mesoporous TiO2 hollow nano sphere, evenly disperse Au nanoparticles are obtained by using anextracting solution of camphor leaves as a biological reductant on the surface of the nano sphere, then in situ growth of an inert oxide ZrO2 layer is conducted for packaging, and finally the nanocomposite with the nucleus-shell structure is obtained and applied to a liquid phase selective oxidizing reaction of benzyl alcohol. The nanocomposite prepared by the method has high thermal stability and excellent catalytic reaction performance, and shows a good application prospect in the field of nano catalysis.
Owner:SOUTHEAST UNIV
Compositions and methods for immune-mediated cancer therapy
ActiveUS20190070186A1Enhance immune responseHydroxy compound active ingredientsEther/acetal active ingredientsOncologySolid tumor
Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a) administering to the subject a hypoxia-activated bioreductive agent (HABA); (b) inducing hypoxia by (i) administering a hypoxia-inducing agent to the subject or (ii) embolizing one or more blood vessels supplying the solid tumor; and (c) administering an immune checkpoint inhibitor prior to, simultaneously with, or subsequent to step (b) in an amount effective to enhance an immune response to the solid tumor, as compared to an immune response in the absence of the immune checkpoint inhibitor. Kits for use in the disclosed methods are also provided.
Owner:TECLISON LTD
A method for preparing titanium dioxide tube-based composite material by biological method
ActiveCN108588130BHigh catalytic efficiencyEasy to solveMicroorganism based processesFermentationNitrobenzeneShewanella oneidensis
The invention discloses a biological method for preparing a titanium dioxide tube-based composite material, which comprises preparation of LB culture medium, preparation of anaerobic culture medium, inoculation and cultivation of MR‑1 bacteria, synthesis of titanium dioxide nanotubes (TNTs), and preparation of mother liquor , the preparation of titanium dioxide nanotube-based composite materials and other steps, using the microorganism Shewanella oneidensis MR‑1 taken from the environment as a biological reducing agent and template agent, to synthesize Ag in situ on the TNTs tube wall 2 S NPs, thereby forming Ag in one step 2 S / TNTs nanotube-based composite material, this method is not only economical, effective, low-carbon and environmentally friendly, it avoids the addition of chemical reagents, and does not consume any energy. At the same time, the Ag produced by this method 2 S / TNTs nanotube-based composite material is used for catalytic reduction of p-nitrophenol, an organic pollutant that is difficult to degrade in the environment and has biotoxicity, and has high catalytic efficiency.
Owner:ANHUI UNIVERSITY
Molten metal antioxidant biological reducing agent and preparation method thereof
InactiveCN102787244BGood emulsificationEasy to cleanHot-dipping/immersion processesPolyethylene glycolOxidation resistant
A molten metal antioxidant biological reducing agent comprises polyethylene glycol oleate, a thermophilic enzyme, a lipase, ammonium dihydrogen phosphate, ethylene diamine tetramethylene phosphonate acid and phytoncid. The molten metal antioxidant biological reducing agent is prepared by adding the components in batches slowly under a certain temperature. The molten metal antioxidant biological reducing agent has high reducing efficiency, is non-toxic, contains no carcinogenic substance, generates less flue and does not corrode machines. Particularly, the molten metal antioxidant biological reducing agent can be used for removing the redundant metal and oxide impurities released onto the surface of tin in a tin furnace to play a role of purifying and can react with a carbonized soldering flux in a high-temperature furnace to exert the reducing effect further to release metal elements. The residues from the reduction of the molten metal antioxidant biological reducing agent are water-soluble, self-degradable, pollution-free and easy to process, conform to environmental protection standards, consume less manpower for management and occupy less space for placement.
Owner:何光宁
Preparation and application of pharmaceutical composition of no donor titanium dioxide derivatives
ActiveCN106362147BGood biocompatibilityStrong targetingOrganic active ingredientsInorganic non-active ingredientsSide effectBiocompatibility Testing
Owner:ZHONGSHUAI PHARMA SCI & TECH CO LTD
Compositions and methods for immune-mediated cancer therapy
ActiveCN108472366AHydroxy compound active ingredientsEther/acetal active ingredientsOncologyCancer therapy
Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a) administering to the subject a hypoxia-activated bioreductive agent (HABA); (b) inducing hypoxia by (i) administering a hypoxia-inducing agent to the subject or (ii) embolizing one or more blood vessels supplying the solid tumor; and (c) administering an immune checkpoint inhibitor prior to, simultaneously with, or subsequent to step (b) in an amount effective to enhance an immune response to the solid tumor, as compared to an immune response in the absence of the immune checkpoint inhibitor. Kits for use in the disclosed methods are also provided.
Owner:TECLISON LTD
Manganese-based magnetic resonance contrast agents
InactiveUS20150336996A1Enhance Mn（II） relaxivityEasy to prepareRadioactive preparation carriersPeptide preparation methodsOxidation stateManganese
Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.
Owner:CARAVAN PETER +5
Dyeing technology without sewage discharging for jean
The invention belongs to the technical field of cloth dyeing and particularly relates to dyeing technology without sewage discharging for jean. The dyeing technology mainly includes that indigo, a biological reducing agent, diffusant and water are mixed to obtain dye, control of yarn humidity and dyeing process temperature is combined, finally jean yarn dyed by the indigo is obtained, and the jean yarn is spun to obtain jean products. Compared with traditional technology, the dyeing technology saves repeated dyeing-oxidization procedures, especially, dyed yarn does not need to be washed with a large amount of water, and the dyeing technology not only saves a large amount of energy, simultaneously greatly reduces damage of sewage on environment, and has remarkable social benefit and economical benefit.
Owner:孙国祥 +2
Methods for treating liver tissue
Methods and kits are provided for administering a hypoxia-activated bioreductive agent by applying the agent locally to liver tissue when hepatic arterial pressure is reduced. Local arterial application when pressure is reduced tissue prolongs the duration of tissue exposure to the hypoxia-activated bioreductive agent. Hepatic pressure may be reduced proximal to the liver tissue. In some embodiments, local application may be followed by embolization when arterial pressure is reduced. Embolization under reduced pressure may decrease complications associated with backflow and increase the efficacy of the hypoxia-activated agent.
Owner:HANGZHOU RAYGENE PHARM CO LTD
A kind of core-shell structure nanocomposite material based on biological method and its preparation method
ActiveCN110368998BSelf-dopingEnhanced mass transferOrganic-compounds/hydrides/coordination-complexes catalystsBENZYL ALCOHOL/WATERNanocomposite
The invention discloses a biological method-based core-shell structure nano-composite material and a preparation method thereof. The nano-composite material is first derived from an amino acid modified by a complexing agent as a biological soft template to derivate an active oxide mesoporous TiO 2 Hollow nanospheres, and then use the extract of cinnamon camphor leaves as a bioreductant to obtain uniformly dispersed Au nanoparticles on the surface, and then in situ grow the inert oxide ZrO 2 The nanocomposite material with core-shell structure was finally obtained and applied to the liquid-phase selective oxidation of benzyl alcohol. The nanocomposite material prepared by the method has high thermal stability and excellent catalytic reaction performance, and shows good application prospects in the field of nanocatalysis.
Owner:SOUTHEAST UNIV
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