33 results about "Bioreductive Agent" patented technology

The invention discloses a method for treating chlorinated organic pollutants in underground water by using a slow-release compound repair material. The method comprises the following steps: (1), preparing charcoal through high temperature pyrolysis; (2), pre-treating zero-valent iron through acid pickling; (3), adding water into the charcoal, then adding xanthan gum and an organic carbon source, and finally, adding zero-valent iron, and through steps of treating, obtaining the slow-release compound repair material; then treating chlorinated organic pollutants in underground water by adopting an in situ injection repairing method or an in situ PRB repairing method. According to the method provided by the invention, the xanthan gum with high mechanical strength and strong mass transfer performance is used as a novel slow release embedding medium, the physical adsorbent charcoal, the chemical reductant zero-valent iron and the bioreductive drug organic carbon source are taken as effective components for composite embedding, so that gel microspheres with stable structures are formed, and the method provided by the invention has the advantages of sustained release, simple and convenient operation, low cost, environment friendliness and the like, can effectively achieve physically, chemically and biologically collaborated and enhanced remediation, and can effectively remove target pollutants.

The invention provides a method for preparing graphene simultaneously doped with nitrogen and sulfur through biological reduction, and belongs to the technical fields of graphene synthesis and a nano material. The method is characterized in that oxidized graphene dispersion solution is used as a raw material, sulfate-containing reduction bacteria suspension is used as a biological reduction agent, the raw material is reacted with the biological reduction agent for 5 to 10 days in a control reaction system under an air insulation condition to obtain a graphene solution, and the graphene solution is centrifugally filtered and repeatedly washed to obtain graphene doped with nitrogen and sulfur. According to the method, no stabilizer or dispersing agent is added, and oxidized graphene is reduced by utilizing the metabolic activity of the microorganisms to obtain graphene doped with nitrogen and sulfur, so that the method has the advantages of safety, no toxicity, simplicity in operation, environmental friendliness and the like, the difficulty that nitrogen and sulfur cannot be simultaneously doped in the existing graphene preparation method can be solved, when graphene simultaneously doped with the nitrogen and sulfur is applied to the fields such as electrochemical sensors, electric catalysis and the like, the detection limit and the detection sensitivity can be remarkably improved, and the application prospect is promising.

Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

A compound of the active anticancer protein and bioreducer for preparing the medicine to treat cancer is prepared from the target protein chosen from transferrin, ceruloplasmin, somatostatin, vitamine bindin, etc and the bioreducer chosen from bifunctional heterocyclic nitro compound, quinone, heterocyclic NOx, topoisomerase B inhibitor and DNA-targeting medicine.

The invention discloses a method for treating chlorinated organic pollutants in underground water by using a slow-release compound repair material. The method comprises the following steps: (1), preparing charcoal through high temperature pyrolysis; (2), pre-treating zero-valent iron through acid pickling; (3), adding water into the charcoal, then adding xanthan gum and an organic carbon source, and finally, adding zero-valent iron, and through steps of treating, obtaining the slow-release compound repair material; then treating chlorinated organic pollutants in underground water by adopting an in situ injection repairing method or an in situ PRB repairing method. According to the method provided by the invention, the xanthan gum with high mechanical strength and strong mass transfer performance is used as a novel slow release embedding medium, the physical adsorbent charcoal, the chemical reductant zero-valent iron and the bioreductive drug organic carbon source are taken as effective components for composite embedding, so that gel microspheres with stable structures are formed, and the method provided by the invention has the advantages of sustained release, simple and convenient operation, low cost, environment friendliness and the like, can effectively achieve physically, chemically and biologically collaborated and enhanced remediation, and can effectively remove target pollutants.

The invention discloses a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater and a preparation method thereof. The preparation method comprises the steps of (1) preparing biochar by high-temperature pyrolysis; (2) pretreating zero-valent iron by acid pickling; and (3) adding water into the biochar, adding xanthan gum and an organic carbon source, adding zero-valent iron finally, and carrying out multi-step treatment on the obtained mixture so as to obtain a slow-release compound repair material for treating chlorine-containing organic pollutants in groundwater. According to the invention, by using the xanthan gum with high mechanical strength and strong mass transfer performance as a novel slow-release embedding agent, the biochar (as a physical adsorbent), the zero-valent iron (as a chemical reductant) and the organic carbon source (as a biological reductant) which are taken as effective components are compositely embedded so as to form constitutionally stable gel microspheres, and the slow-release compound repair material has the advantages of long-term slow-release, easy operation, low cost, environment friendliness, and the like, and can effectively realize the physical, chemical and biological synergistic reinforced repair, therefore, the material can remove target pollutants more efficiently.

Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.

Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a) administering to the subject a hypoxia-activated bioreductive agent (HABA); (b) inducing hypoxia by (i) administering a hypoxia-inducing agent to the subject or (ii) embolizing one or more blood vessels supplying the solid tumor; and (c) administering an immune checkpoint inhibitor prior to, simultaneously with, or subsequent to step (b) in an amount effective to enhance an immune response to the solid tumor, as compared to an immune response in the absence of the immune checkpoint inhibitor. Kits for use in the disclosed methods are also provided.

The invention discloses a biological method for preparing a titanium dioxide tube-based composite material, which comprises preparation of LB culture medium, preparation of anaerobic culture medium, inoculation and cultivation of MR‑1 bacteria, synthesis of titanium dioxide nanotubes (TNTs), and preparation of mother liquor , the preparation of titanium dioxide nanotube-based composite materials and other steps, using the microorganism Shewanella oneidensis MR‑1 taken from the environment as a biological reducing agent and template agent, to synthesize Ag in situ on the TNTs tube wall 2 S NPs, thereby forming Ag in one step 2 S / TNTs nanotube-based composite material, this method is not only economical, effective, low-carbon and environmentally friendly, it avoids the addition of chemical reagents, and does not consume any energy. At the same time, the Ag produced by this method 2 S / TNTs nanotube-based composite material is used for catalytic reduction of p-nitrophenol, an organic pollutant that is difficult to degrade in the environment and has biotoxicity, and has high catalytic efficiency.

A molten metal antioxidant biological reducing agent comprises polyethylene glycol oleate, a thermophilic enzyme, a lipase, ammonium dihydrogen phosphate, ethylene diamine tetramethylene phosphonate acid and phytoncid. The molten metal antioxidant biological reducing agent is prepared by adding the components in batches slowly under a certain temperature. The molten metal antioxidant biological reducing agent has high reducing efficiency, is non-toxic, contains no carcinogenic substance, generates less flue and does not corrode machines. Particularly, the molten metal antioxidant biological reducing agent can be used for removing the redundant metal and oxide impurities released onto the surface of tin in a tin furnace to play a role of purifying and can react with a carbonized soldering flux in a high-temperature furnace to exert the reducing effect further to release metal elements. The residues from the reduction of the molten metal antioxidant biological reducing agent are water-soluble, self-degradable, pollution-free and easy to process, conform to environmental protection standards, consume less manpower for management and occupy less space for placement.

The invention relates to preparation and applications of a medicinal composition of a NO-donating titanium dioxide derivative, for effectively realizing the treatment medication aiming at tumor, and realizing the diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation comprises the following steps: reacting hollow mesoporous titanium dioxide nano particles and mercaptopropyl triethoxysilane to obtain a sulfhydryl hollow mesoporous titanium dioxide compound, reacting the sulfhydryl hollow mesoporous titanium dioxide compound with tert-butyl nitrite to obtain the NO-donating titanium dioxide derivative, and finally, loading an antitumor drug such as a bioreductive agent. The preparation and applications have the advantages that the operation is convenient, the method is stable and reliable, the prepared NO-donating titanium dioxide and the medicinal composition of the NO-donating titanium dioxide have the advantages that the biocompatibility is good, the targeting ability is strong, the toxic and side effects are small, etc., in the aspect of tumor treatment, the ultrasonic therapy of TiO2, the anti-tumor therapy effect of NO, and the lethal effect of the bioreductive agent can be exerted, meanwhile, the early-stage diagnosis and later-stage treatment can be integrated by utilizing the ultrasonic imaging property of the generated NO gas, and therefore, the technical scheme belongs to an innovation in the tumor treatment medicines.

Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a) administering to the subject a hypoxia-activated bioreductive agent (HABA); (b) inducing hypoxia by (i) administering a hypoxia-inducing agent to the subject or (ii) embolizing one or more blood vessels supplying the solid tumor; and (c) administering an immune checkpoint inhibitor prior to, simultaneously with, or subsequent to step (b) in an amount effective to enhance an immune response to the solid tumor, as compared to an immune response in the absence of the immune checkpoint inhibitor. Kits for use in the disclosed methods are also provided.

The invention belongs to the technical field of cloth dyeing and particularly relates to dyeing technology without sewage discharging for jean. The dyeing technology mainly includes that indigo, a biological reducing agent, diffusant and water are mixed to obtain dye, control of yarn humidity and dyeing process temperature is combined, finally jean yarn dyed by the indigo is obtained, and the jean yarn is spun to obtain jean products. Compared with traditional technology, the dyeing technology saves repeated dyeing-oxidization procedures, especially, dyed yarn does not need to be washed with a large amount of water, and the dyeing technology not only saves a large amount of energy, simultaneously greatly reduces damage of sewage on environment, and has remarkable social benefit and economical benefit.

Methods and kits are provided for administering a hypoxia-activated bioreductive agent by applying the agent locally to liver tissue when hepatic arterial pressure is reduced. Local arterial application when pressure is reduced tissue prolongs the duration of tissue exposure to the hypoxia-activated bioreductive agent. Hepatic pressure may be reduced proximal to the liver tissue. In some embodiments, local application may be followed by embolization when arterial pressure is reduced. Embolization under reduced pressure may decrease complications associated with backflow and increase the efficacy of the hypoxia-activated agent.

The invention discloses a biological method-based core-shell structure nano-composite material and a preparation method thereof. The nano-composite material is first derived from an amino acid modified by a complexing agent as a biological soft template to derivate an active oxide mesoporous TiO 2 Hollow nanospheres, and then use the extract of cinnamon camphor leaves as a bioreductant to obtain uniformly dispersed Au nanoparticles on the surface, and then in situ grow the inert oxide ZrO 2 The nanocomposite material with core-shell structure was finally obtained and applied to the liquid-phase selective oxidation of benzyl alcohol. The nanocomposite material prepared by the method has high thermal stability and excellent catalytic reaction performance, and shows good application prospects in the field of nanocatalysis.