A making method of a handcraft picture comprises the following steps: first making a bottom plate, and the bottom plate are made into various types such as scroll painting, oil paining or craft decoration and the like according to the content of the made handcraft picture; drawing a pattern or adhering a picture or a photograph on the bottom plate according to the requirement of the made handcraft picture, opening holes at positions needing light transmission, such as positions of the sun, the moon, the star and the like, and installing a lamp to improve the decoration effect; and taking various objects such as animal speciums, herbarium, stone and the like as making materials of the handcraft picture, fixing the materials on the bottom plate by methods such as nailing, adhesion, embedding and the like, thus forming the vivid, natural and beautiful three-dimensional handcraft picture; and the handcraft picture made by adopting the method has strong cubic feeling and good decorative effect, and is exquisite and beautiful, can reflect the combination of nature and human, and has splendid showing, and beautiful and generous expression.