The invention relates to a host controller drive implementation method of high-capacity storage equipment in a VxWorks system, and belongs to the technical field of embedded communication. The methodcomprises the following steps: firstly, replacing a PCI (Peripheral Component Interconnect) configuration space by utilizing a BSP (Basic Service Provider) under a VxWorks system, and cutting off a related function for calling a PCI bus in the system to realize direct access to a host controller; Secondly, mapping the CPU address into a PCI address, obtaining a register base address for initializing a host controller by utilizing a conversion function from a physical address to a virtual address, and modifying an interrupt function of the host controller; And finally, different types of HCDs are hung on the USBD by utilizing host controller port routing control logic, so that the support for three transmission rates, namely low speed, full speed and high speed, is realized. According to the method, the problem that the transmission rate of the PCI-based host controller is low can be solved, meanwhile, a good solution is provided for achieving drive development of the non-PCI host controller under VxWorks, and the read-write speed of the high-capacity storage device is increased.