The invention discloses an anti-locking control method for turn-back region running of a rail intersecting train. The method includes the steps that a rail access transaction region and a turn-back region are arranged; the train checks whether the rail access transaction region is locked or not, if the rail access transaction region is locked, the train waits for the rail access transaction region to be unlocked in front of the rail access transaction region, and if the rail access transaction region is not locked, the train enters the rail access transaction region; the train reaches the rail access transaction region and checks whether the turn-back region is occupied by another train or not, if the turn-back region is occupied by another train, rail access is not transacted, and the train waits in the rail access transaction region; if the turn-back region is not occupied by another train, the train obtains the use right of the turn-back region, rail access is transacted, and the train enters the turn-back region; the train reaches a turn-back point, and the rail access transaction region is unlocked; and after the train leaves the turn-back region, the turn-back region occupation right is released. By the adoption of the method, the train can be accurately controlled and dispatched, the train efficiently passes through the turn-back region in order, and the situation that the train is locked in the turn-back region is avoided.