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The invention discloses a preparation method of maltodextrin for synthesizing ferric carboxymaltose. The method comprises the following steps: adding pullulanase into commercially available maltodextrin in water to carry out branching reaction, and carrying out enzyme removal operation to obtain maltodextrin of which the branching degree (BD value) is 0-3.0% and the reducing sugar equivalent (DE value) is 8.0-16.0%. The maltodextrin prepared by the method is used for synthesizing ferric carboxymaltose, the particle size of the maltodextrin is 24.0-28.0 nm, the particle size distribution PDI is less than or equal to 0.14, the diameter of an iron core is 4.95-5.25 nm, and the maltodextrin is highly consistent with an original product.

This invention belongs to the field of pharmaceutical synthesis and discloses a method for preparing carboxylated maltose iron, comprising: adding sodium carbonate solution to a mixture of carboxylated maltodextrin solution and ferric chloride solution in two separate additions, controlling the amount of sodium carbonate solution added in the first addition to be 20-40% of the total amount of sodium carbonate solution, and the time interval between the two additions of sodium carbonate solution to be 10-40 minutes, to obtain carboxylated maltose iron with the target molecular weight and molecular weight distribution coefficient. In actual production, this invention not only significantly reduces the reaction temperature but also significantly reduces the complexation reaction time, achieving the effect of shortening the reaction cycle and saving energy. While ensuring the acquisition of carboxylated maltose iron with the target molecular weight and molecular weight distribution, it conforms to the trend of energy conservation and environmental protection, and has significant practical value.

The invention provides a method for simultaneously extracting rhaponticin, deoxyrhaponticin and anthraquinone compounds from rheum officinale, which can solve the problems of resource waste, high cost, complex process and low recovery rate caused by the fact that rhaponticin, deoxyrhaponticin and anthraquinone compounds cannot be simultaneously obtained by the existing method. The method comprises the following steps: cooking raw materials with boiling water to obtain a first filtrate and residues; adding industrial ammonia water and a first alcohol solution into the residues, stirring, extracting and filtering to obtain a second filtrate, concentrating, refrigerating and filtering to obtain a third filtrate and a first precipitate; modifying macroporous adsorption resin; dissolving the first precipitate with a small-polarity organic solvent, filtering to obtain a fourth filtrate and a second precipitate, concentrating, centrifuging, and combining a clear liquid with the first filtrate and the third filtrate to obtain a mixed liquid; adsorbing the mixed solution with modified macroporous adsorption resin, washing with water, eluting, concentrating and drying to obtain the anthraquinone compound; dissolving the second precipitate, filtering to obtain a fifth filtrate and a third precipitate, and concentrating and crystallizing to obtain a rhaponticin crude product; and refining.