Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Torasemide freeze-drying preparation and prepration method

A torasemide and freeze-drying technology, which is applied in the direction of freeze-drying delivery, drug combination, blood diseases, etc., can solve the problems of increasing related substances, vascular stimulation, and affecting curative effect

Active Publication Date: 2008-03-05
南京海辰药业股份有限公司
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also people who increase the water solubility of torasemide by adding polyethylene glycol-400 and prepare it into injections. Since torasemide has an amide bond in its molecular structure, it is easily hydrolyzed after being prepared into a liquid preparation, resulting in a decrease in drug content. The increase of related substances will affect the curative effect, and it is not suitable for long-term storage
In addition, injections with polyethylene glycol-400 added are less stable
Moreover, polyethylene glycol-400 has a stimulating effect on blood vessels, which is not conducive to long-term large-scale use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Torasemide freeze-drying preparation and prepration method
  • Torasemide freeze-drying preparation and prepration method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Torsemide 10g

[0031] Sodium bicarbonate 20g

[0032] Mannitol 100g

[0033] Makes 1000 bottles

[0034] In the aseptic weighing room, take prescription amount torasemide and sodium bicarbonate respectively, add the water for injection of 75% prescription amount (1500ml) in the liquid mixing bucket, slowly add torasemide and sodium bicarbonate, Stir, add an appropriate amount of 10% NaOH solution, adjust the pH to 9.0, stir to fully dissolve the main ingredient, then add the prescribed amount of mannitol, stir to dissolve, add water for injection to 2000ml, add 0.05% activated carbon for needles, and stir at room temperature For 10 minutes, use a sterile sand core to filter and decarbonize, and filter with a microporous membrane (0.22 μm). After passing the quality inspection, the filtrate is divided into 2ml vials, freeze-dried, aseptically sealed, and packaged. Instantly.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A freeze-dried composition of torasemide features that it contains sodium hydrogen carbonate for higher solubility. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a torasemide freeze-dried preparation and a preparation method. Background technique [0002] Torsemide, the English name is Torsaemide, [0003] The chemical structural formula is as follows: [0004] [0005] Molecular formula: C 16 h 20 N 4 o 3 S [0006] Molecular weight: 348.43 [0007] It is white or off-white loose lumps. It is a new generation of sulfonylurea loop diuretics researched and developed by Boehringer Mannheim in Germany. It was first launched in Germany in 1993 and approved by the US FDA in 1994. The drug is sold in many countries and regions such as the United States, Canada, Switzerland, and Hong Kong. This drug is the fourth loop diuretic on the market today. It is mainly used clinically to treat various edemas caused by congestive heart failure, kidney or liver diseases, etc. And various types of hypertension, it is a milestone drug i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/44A61K9/19A61P9/12A61P7/10
Inventor 曹于平蒋金元冒宜兰
Owner 南京海辰药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com