Propylamine derivative and its application in preparing tomocetin
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- EAST CHINA UNIV OF SCI & TECH
- Publication Date
- 2008-11-05
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to a kind of propylamine derivative and application thereof, specifically relate to a kind of N-methyl, N-benzyl or substituted benzyl, 3-phenyl, 3-o-tolyloxypropylamine and its preparation of tomoxicillin Ting (atomoxetine racemate) in the application. Background technique
[0002] Atomoxetine hydrochloride (Atomoxetine HCl,), the chemical name is (+)-(R)-N-methyl-3-(2-methylphenoxy)-3-amphetamine hydrochloride, is Selective serotonin (5-HT) reuptake inhibitor antidepressants are also good drugs for treating attention deficit disorder and hyperactivity disorder.
[0003] At present, the methods for preparing atomoxetine are mainly divided into two categories: one is to directly prepare atomoxetine by asymmetric synthesis; the other is to first synthesize atomoxetine racemate (atomoxetine , whose structure is shown in Formula 1), and then obtain the target object by splitting atomoxetine. The second method is currently ...