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Method for preparing ophthalmic solution for preventing senile macular degeneration by using microoganism culture

An eye drop, senile technology, applied in the direction of drug combination, bacteria, sensory diseases, etc., can solve problems such as difficulty in implementation, and achieve the effects of reducing tension, eliminating microvascular spasm, and inhibiting occurrence and development.

Inactive Publication Date: 2009-01-14
邹庆宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some drugs can be injected directly into the brain or the eye, but for chronic diseases or special conditions that require long-term treatment, this method is really difficult to implement, which is why proteins are difficult to use in eye treatments.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of medium:

[0034] Preparation of pig heart extract: take fresh pig heart, remove blood clots, fat and fascia, wash it with water, crush it, weigh it, add twice the amount of water for injection, store it at 4°C for 14 hours, take it out, and boil it for two hours. Heat and filter with eight layers of gauze, and then use a Buchner funnel to suction filter to obtain a clear yellow liquid for later use.

[0035] Preparation of pig heart peptone medium: Weigh 2 g of peptone and 0.9 g of sodium chloride, measure 20 ml of pig heart extract, add water for injection to 100 ml, heat to dissolve, stir evenly, and sterilize to prepare pig heart peptone medium for later use.

[0036] (2) Preparation of Staphylococcus aureus yellow subspecies seed solution:

[0037] After opening the strain of Staphylococcus aureus subsp. yellow, transfer it to the pig heart peptone medium, cultivate it at 36°C±1°C for 24 hours, then transfer it to the nutrient agar plate, divide ...

Embodiment 2

[0041] Yandikang Eye Drops Formula: Fermented Bacteria Liquid 100ml

[0042] Sodium chloride 8.1g

[0043] Add water for injection to prepare 1000ml Yandikang Eye Drops

[0044] Preparation method: Weigh 8.1g of sodium chloride, dissolve it with about 800ml of water for injection, then add 100ml of fermented bacteria liquid, stir evenly, add water for injection to a total of 1000ml, stir well, and filter with a 0.22μm microporous membrane , autoclaved at 115°C, cooled, subpackaged into 1ml, packaged, vested, and the pH value of the product is 5.0-7.0.

Embodiment 3

[0046] Yandikang Eye Drops Formula: Fermented Bacteria Liquid 80ml

[0047] Sodium chloride 6.1g

[0048] Add water for injection to prepare 1000ml Yandikang Eye Drops

[0049] The preparation method is the same as in Example 2.

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Abstract

A process for preparing the eye drops used to prevent and suppress senile macular degeneration includes such steps as revival of Staphylococcus aureus, preparing the seed culturing liquid and fermenting culture bacterium liquid in hog heart pepton as culture medium, proportionally mixing cultured bacterial liquid, sodium chloride and the water for injection, filtering and sterilizing.

Description

(1) Technical field: [0001] The invention relates to a method for preparing Yandikang eye drops for preventing and inhibiting age-related macular degeneration by using metabolites of Staphylococcus aureus subsp. , has a regulating effect on the ciliary muscle, and can also improve eye microcirculation. (two) background technology: [0002] Age-related macular degeneration (AMD) is also known as age-related macular degeneration or aging macular degeneration. Most of them start around the age of 50, and the older the age, the higher the incidence rate. The incidence has no obvious relationship with gender and race. Both eyes are affected simultaneously or successively. Due to different clinical manifestations, it can be divided into two types: atrophic (dry) and exudative (wet). The former is more common, while the latter is only 1 / 15 to 1 / 10 of the former. Black dots or dark shadows appear, visual fatigue, difficulty in reading, severe impact on vision in the middle and l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/74A61P27/02
Inventor 邹庆宇
Owner 邹庆宇
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