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Method for refining Radix astragali polysaccharide

The technology of astragalus polysaccharide and microfiltration membrane is applied in the field of pharmacognostics, and can solve the problems of low extraction rate and purity of astragalus polysaccharide, long heating time, complicated steps, etc., so as to avoid thermal decomposition, the method is simple, the extraction rate is improved, and the extraction rate is improved. The effect of product purity

Inactive Publication Date: 2009-06-24
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the current problem of extracting and separating astragalus polysaccharides from astragalus, long heating time, high energy consumption, and complicated steps, resulting in low extraction rate and purity of astragalus polysaccharides and low efficiency, the present invention is proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 0.2 μm microfiltration membrane, and add 4 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 1,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 81.50 grams of astragalus polysaccharides with a purity of 86.29% (measured by the phenol-sulfuric acid method, the same below).

Embodiment 2

[0025] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 1.4 μm microfiltration membrane, and add 2 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 71.36 grams of astragalus polysaccharide with a purity of 89.73%.

Embodiment 3

[0027] Take 1 kg of Radix Astragali, pulverize it, and extract it by microwave (70°C, 4 times, 30 minutes / time) to obtain a water extract. Filter, and then pass the filtrate through a 0.14 μm microfiltration membrane, and add 5 times the amount of water to dilute during the process of passing through the membrane (continuously add water according to the amount of permeation). The filtrate was collected and concentrated through an ultrafiltration membrane with a molecular weight cut-off of 5,000 Daltons. The retentate was collected, precipitated with alcohol, and dried to obtain 77.93 grams of astragalus polysaccharide with a purity of 81.86%.

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PUM

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Abstract

The invention discloses a method for refining astragalus polysaccharide. At present, the method of extracting and separating astragalus polysaccharides from astragalus is mainly water extraction and alcohol precipitation method. The extraction rate and purity of astragalus polysaccharides by this method are not high, and the evaporation and concentration time is long, which is easy to cause the decomposition of polysaccharides, which brings inconvenience to the actual operation. . The method of the present invention combines microwave extraction, microfiltration, ultrafiltration and alcohol precipitation techniques to refine the astragalus polysaccharide, which can effectively improve the extraction rate and product purity, and the process is simpler, and has the characteristics of time saving, energy saving, high efficiency, convenience and the like.

Description

technical field [0001] The invention relates to the field of pharmacognosy, in particular to a method for refining astragalus polysaccharides by combined application of microwave extraction, microfiltration, ultrafiltration and alcohol precipitation techniques. Background technique [0002] Radix Astragalus (Radix Astragalus) is the dried root of Astragalus membranaceus (Fisch) Bge or Astragalus membranaceus (Fisch) Bge.Var.mongholicus (Bge) Hsiao) of the leguminous plant. Sweet, slightly warm in nature, invigorating qi and solidifying the surface, diuresis and treating sores. Modern pharmacological studies have shown that astragalus polysaccharide is one of the main components of astragalus, which has a wide range of pharmacological effects such as improving immunity, anti-tumor, anti-radiation damage, antibacterial and anti-virus, regulating blood sugar, and anti-aging. [0003] The method of extracting and isolating astragalus polysaccharides from astragalus is mainly wa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00
Inventor 杨义芳许海燕黄春跃
Owner SHANGHAI INST OF PHARMA IND CO LTD