Povidone-iodine bubble agent and preparing method

A technology of povidone-iodine and foaming agents, which is applied in the fields of pharmaceutical formulations, aerosol delivery, and medical preparations of non-active ingredients, etc., and can solve problems such as narrow spreading area, uneven drug dispersion, and cross-infection

Inactive Publication Date: 2007-09-12
郑起平 +1
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

But suppository belongs to solid dosage form, and it has some problems when it is actually used, and suppository has a process of softening and dissolving in vagina, and exerts drug effect slowly, and medicine dispersion is uneven,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0022] Example 2: According to the above research, 200 g of povidone-iodine, 5 g of sodium lauryl sulfate, 100 g of glycerol, 10 g of polysorbate-80, and water were added to make 1000 g of the total. Take the above-mentioned povidone-iodine raw materials, add an appropriate amount of water and mix with polysorbate-80 to dissolve, then add glycerin and sodium lauryl sulfate respectively, and add water to about 950g, stir to dissolve, add water to 1000g, and mix well , adjust the pH value, filter, pour into the container, screw on the foam lotion pump (or foam pump, manual foam generating device), and generate foam by pressing the lotion pump by hand.

[0023] According to the above prescription and preparation method, the prepared povidone-iodine foam solution is uniform, the foam is abundant and the duration is long, indicating that the process is feasible.

[0024] 5. Effects of temperature and light on preparations Povidone-iodine is unstable under long-term light exposure a...

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PUM

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Abstract

The present invention is polyvidone iodine foam agent and its preparation process. The process of preparing polyvidone iodine foam agent includes the steps of: dissolving polyvidone iodine in water; adding span-80, sodium dodecyl sulfate, glycerin, etc via homogeneous mixing; adding distilled water via stirring and regulating pH value; filling the mixture into container, setting in emulsion pump and pressing the emulsion pump manually to generate foam. The foam agent makes its medicine distributed inside vagina or on the surface of skin to take action fast. The foam agent has fast and high treating effect, high safety and use convenience, and is one good medicine for treating gynecologic diseases.

Description

technical field [0001] The invention relates to a foaming agent and a preparation method thereof, in particular to a povidone-iodine foaming agent and a preparation method thereof. Background technique [0002] Foams (ie, emulsion-type aerosols) have been included in the Chinese Pharmacopoeia and ministerial standards as a pharmaceutical dosage form. It is made by adding a propellant into a pressure vessel. [0003] Gynecological inflammation is a common and frequently-occurring disease. Currently, suppositories are the most effective and convenient drug formulations for the treatment of such diseases. However, suppository is a solid dosage form, it has some problems in specific use. The suppository has a softening and dissolving process in the vagina, and the drug effect is slow, and the drug is not uniformly dispersed, and the distribution surface is narrow; the suppository is used manually, not only easy to use Contaminate the medicine, and may cause cross-infection; in...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/80A61K47/20A61K47/12A61K47/10A61K47/14A61K47/24A61K47/34A61P15/02A61P31/00A61K47/26
Inventor 郑起平吕武清
Owner 郑起平
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