Application of self-assembled short peptide in the medicine for treating burn and face wound

A self-assembled short peptide and wound surface technology, which is applied in drug delivery, drug combination, and pharmaceutical formulations, can solve problems such as poor biocompatibility, strong toxicity, and difficult to degrade, and achieve the effect of balancing conditions and relieving pain

Inactive Publication Date: 2007-09-19
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic dressings use polymer materials as raw materials, which have problems such as poor biocompatibility, difficult to degrade, and strong toxicity

Method used

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  • Application of self-assembled short peptide in the medicine for treating burn and face wound
  • Application of self-assembled short peptide in the medicine for treating burn and face wound
  • Application of self-assembled short peptide in the medicine for treating burn and face wound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] 1. Materials and methods

[0024] 1.1 Materials

[0025] 1.1.1 Animals

[0026] The experimental animals (SD rats) come from the West China Experimental Animal Center, with a body weight of 200g-290g. Before the experiment, let the animals adapt to a feeding room with a clean constant temperature (20°C ± 2°C) and constant humidity (humidity 50%) for one week. A total of 92 animals were used, among which, 80 were used in the scald apparatus to prepare burn models, and 12 were used in flame burns to prepare burn models.

[0027] When the burn model was prepared with a scald instrument, according to the principle of randomization, 3 animals were used for each time window for each material, and a total of 5 materials including self-assembled short peptide RADA16-I, chitosan, collagen, blank control group, and polylactic acid were used for a total of 15 animals. Only. Three time windows were designed, respectively on the 7th, 10th, and 14th day, and each time window was a...

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Abstract

The invention discloses an application of a self-assembled short-peptide RADA16-1 for preparation of medicine for curing burn wound. Model of rat burned skin is established by using temperature adjusting mode electrical scald instrument and flame. Hydrogel formed by self-assembled short-peptide RADA16-1 and typic medicines for curing burn wound as dressing such as chitosan, collagen, polylactic acid perform therapeutic experiment. The results show that the self-assembled short-peptide RADA16-1 can control the extension of burn wound and edema, promote the ordered rearrangement of collagen of burn wound, burn wound healing, regenerating and repairing the skin and the appendage of skin tissue. Compared with the chitosan, collagen, polylactic acid, the said medicine has better curative effect.

Description

technical field [0001] The present invention relates to the application of self-assembled short peptide RADA16-1, especially the application in the preparation of medicine for treating burn wounds. Background technique [0002] In engineering construction, industrial production and daily life, fires occur from time to time, so there is inevitably fire damage to the human body. Even if no fire occurs, in some cases (such as improper operation of welders and furnace workers, household appliances Improper use, etc.) can also cause burns to the human body. Severe burn patients have long treatment time, many complications, and high disability rate. Especially deep burns often lead to different degrees of scars after recovery, and even disfigurement affects the appearance. In severe cases, tissue activities can be restricted and function loss. Post-operative plastic surgery corrects dysfunction and / or cosmetics. Unfortunately, many patients still end u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K9/00A61P17/02
Inventor 赵晓军孟辉陈丽艳王松涛叶朝阳
Owner SICHUAN UNIV
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