Polyalkylcyanoacrylate nano-capsule and preparation method and application thereof

A technology of polyalkylcyanoacrylate and nanocapsules, which is applied in the field of nanocapsules, can solve the problems of low drug loading of fat-soluble drugs, doubtful biocompatibility, complicated process, etc., and achieve improved bioavailability and stability Sex, reduce adsorption, simple preparation process

Inactive Publication Date: 2011-03-23
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is complex, difficult to control, and requires the use of toxic reagents, which makes the biocompatibility of PEG-co-PACA questionable
Due to the strong hydrophilicity of polyethylene glycol polyalkylcyanoacrylate nanoparticles, the drug-loading capacity of fat-soluble drugs is low when it is used as a drug delivery carrier.

Method used

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  • Polyalkylcyanoacrylate nano-capsule and preparation method and application thereof
  • Polyalkylcyanoacrylate nano-capsule and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Add 10mg of medium-chain triglyceride Miglyol812 to 10ml containing 10% mPEG2000 at a concentration of 0.1mol L -1 hydrochloric acid solution, and probe-type ultrasonic dispersion for 150s to obtain a nanoemulsion. 100 μl of n-butyl cyanoacrylate was dropped into the above microemulsion. Ultrasound and stirring at room temperature for 4 hours to obtain a nanocapsule solution.

Embodiment 2

[0047] Add 50mg of medium chain triglyceride Miglyol812 to 10ml containing 2% mPEG2000 to a concentration of 0.1mol L -1 Hydrochloric acid solution, probe-type ultrasonic dispersion for 50s, to obtain nanoemulsion. 200 μl of n-butyl cyanoacrylate was dropped into the above microemulsion. Ultrasound and stirring at room temperature for 3 h to obtain the nanocapsule solution.

Embodiment 3

[0049]Add 100mg of medium-chain triglyceride Miglyol812 to 10ml containing 20% ​​mPEG2000 to a concentration of 0.1mol·L -1 Hydrochloric acid solution, probe-type ultrasonic dispersion for 50s, to obtain nanoemulsion. 100 μl of n-butyl cyanoacrylate was dropped into the above microemulsion. Ultrasound and stirring at room temperature for 24 hours to obtain a nanocapsule solution.

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Abstract

The invention belongs to the field of nano-capsule and specifically discloses a poly(alkyl cyanoacrylate) nanometer and its preparation method and application. The inventive poly (alkyl cyanoacrylate) nano-capsule comprises liquid fatty acid ester as capsule core and polyethylene glycol modified poly(alkyl cyanoacrylate) as capsule shell. The preparation method comprises adding liquid fatty acid ester into acid solution containing polyethylene glycol, ultrasonic treating to obtain micro emulsion, adding cyano-acrylic acid alkyl ester into the micro emulsion, ultrasonic treating, and stirring for reacting to obtain final product. The nano-capsule can be used as medicinal carrier material. Compared with present technology, the nano-capsule has good stability and high content of hydrophobic ingredient. The preparation method has simple process, easy control, no requirement of toxic agent.

Description

technical field [0001] The invention belongs to the technical field of nanocapsules, and in particular relates to a polyethylene glycol-modified polyalkylcyanoacrylate nanocapsule and its preparation method and application. Background technique [0002] Alkyl cyanoacrylate (ACA) is a commonly used biomedical material, which is widely used in medical fields such as surgical suture and tissue engineering because of its good biodegradability and low toxicity. Alkyl cyanoacrylate has high reactivity, and a trace amount of nucleophilic substances (such as water molecules) at room temperature can initiate polymerization. In the late 1970s, Couvreur was the first to use stabilizers in 10 -2 ~10 -3 mol L -1 Polyalkylcyanoacrylate nanoparticles were synthesized in hydrochloric acid solution (Couvreur P, et al., J. Pharm. Sci. 1979, 68, 1521-1524). Since then, the research on polyalkylcyanoacrylate (PACA) nanoparticles has been paid more and more attention. The traditional prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/34A61K9/50B01J13/14
Inventor 印春华张昱
Owner FUDAN UNIV
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