Anti Toll-like receptor 2 antibody inhibiting tumor metastasis use

Abstract

The present invention discloses an anti-TLP2 antibody. Said anti-TLR2 antibody can inhibit tumor, specially can inhibit the metastasis of B16 melanin tumor. Said anti-TLR2 antibody not only can block TLR2 activity, but also can obviously reduce number of metastatic foci of lung. At the same time, said invention finds that the bleomycin and said anti-TLR2 antibody have good synergistic action.

Description

technical field [0001] The invention relates to a new application of an anti-Toll-like receptor 2 antibody in the prevention and treatment of tumor metastasis, and belongs to the technical field of medicine. Background technique [0002] Cancer (tumor) is a disease that seriously endangers human health. As many as 90% of cancer patients ultimately die from tumor metastasis rather than the tumor itself. Moreover, there is no specific drug for the treatment of tumor metastasis so far. Tumor metastasis is a continuous and complex process in which cancer cells interact with host cells. Firstly, cancer cells degrade the basement membrane and other extracellular matrix and leave the original place to enter the interstitium, lymphatic vessels and blood vessels, and then reach new organs along the blood stream or lymphatic circulation; secondly, activate cells to synthesize and secrete various degradative enzymes , degrade the basement membrane and the matrix at the cell, pass th...

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Problems solved by technology

There is no report about the role of TLR agonists / inhibitors in the process of tumor metastasis

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