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Hypericum attenuatum extraction and its application

A technology of St. John's Wort and its extract, which is applied in the field of extracts. It can solve the serious side effects of St. John's Wort and other problems, and achieve the effect of stable and regular ECG, good reproducibility, and increased myocardial contractility.

Active Publication Date: 2008-04-30
李冀 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem of severe side effects of existing western medicines for treating heart disease and the fact that Hypericum adenocarpus is not used in the treatment of heart disease, and provides an extract of Hypericum adenocarpus and its application

Method used

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Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0018] Specific embodiment one: the hypericum arginata extract of the present embodiment is extracted from Hypericum adenocarpi, and extraction is carried out according to the following steps: 1. Get the dried product of Hypericum adenocarpi and pulverize it into a coarse powder , use ethanol purification to remove impurities, and filter the extract; 2. Concentrate the extract under reduced pressure at a temperature lower than 80°C to a clear paste with a relative density of 1.10 to 1.40, and load it on a macroporous resin column. Load the sample at a ratio of 1:4 to 8 in the mass ratio of the clear cream to the resin, then elute with ethanol with a mass concentration of 30% to 90% and a volume 2 to 5 times the volume of the macroporous resin column, and collect the eluate Under the condition of lower than 60°C, it is dried under reduced pressure until the moisture content is less than 5%, and then crushed into fine powder; namely, hypericum arvensis extract is obtained.

specific Embodiment approach 2

[0019] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 60-75° C. to a clear paste with a relative density of 1.20-1.30. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0020] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in the second step of extraction, the extract is concentrated under reduced pressure at 70° C. to a clear paste with a relative density of 1.25. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The extract of hypericum arvensis and its application relates to an extract and its application. The invention solves the problem of severe side effects of existing western medicines for treating heart disease and the report that Hypericum adenocarpus is not used for heart disease treatment. The Hypericum arginata extract of the present invention is extracted from Hypericum arginata, and the extraction is carried out according to the following steps: 1. Reflux; 2. Concentration, sample loading, eluting, drying; Hypericum extract. The hypericum arginata extract of the present invention is used for treating heart disease. The extract of the invention has the advantages of obviously inhibiting arrhythmia, obvious dose-effect relationship, and no toxic and side effects.

Description

technical field [0001] The present invention relates to an extract and its application. Background technique [0002] Arrhythmia in modern medicine belongs to the category of "palpitations and palpitations" in Chinese medicine, and is one of the common and frequently-occurring diseases of cardiovascular diseases. Arrhythmia can cause abnormal blood circulation. When arrhythmia occurs, the contraction program of atrium and ventricle changes, which can reduce cardiac output by about 30%, causing symptoms such as weak heart, chest tightness, and weakness in patients, and aggravating heart disease. Severe arrhythmias can cause sinus arrest, sinoatrial block, and bradycardia, resulting in tachycardia syndrome. Arrhythmia can also lead to sudden death. According to clinical statistics, arrhythmia is the most common cause of sudden death, among which ventricular tachycardia, ventricular fibrillation and conduction block have the highest incidence of sudden death. Therefore, the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/06A61P9/00
Inventor 李冀高彦宇
Owner 李冀
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