Antioxidation SOD oral spray and preparing method thereof

An oral spray, anti-oxidation technology, applied in the direction of biochemical equipment and methods, anti-toxic agents, redox enzymes, etc., can solve the problem of insufficient absorption and utilization of SOD and safety, heat resistance, acid resistance, alkali resistance and enzymolysis resistance Poor, low absorption utilization rate and other problems, to achieve the effect of improving bioavailability, prolonging storage time and improving stability

Inactive Publication Date: 2017-01-11
陈石良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products involved in these patent applications are basically composed of SOD and traditional Chinese medicine extracts, and are taken orally through the digestion and absorption of the gastrointestinal tract to enter the body to play a role, but because SOD is a type of protease, its heat resistance , acid resistance, alkali resistance and enzymolysis resistance are relatively poor. After oral administration, it is easily damaged by gastric acid and decomposed by pepsin, and its absorption and utilization rate is greatly reduced. bring certain side effects
Therefore, there are deficiencies in the prior art schemes in terms of SOD absorption utilization and safety

Method used

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  • Antioxidation SOD oral spray and preparing method thereof
  • Antioxidation SOD oral spray and preparing method thereof
  • Antioxidation SOD oral spray and preparing method thereof

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preparation example Construction

[0037] Another object of the present invention is to provide a preparation method of anti-oxidation SOD oral spray, which is characterized in that: it contains the following components by weight percentage: superoxide dismutase (SOD) 0.1-2.0%, vitamin C 1.0 ~5.0%, trehalose 1.0~3.5%, green tea extract EGCG 0.2~1.0%, deionized water balance, specifically include the following steps:

[0038] (1) Weigh the formula amounts of SOD, vitamin C, green tea extract EGCG, trehalose, and deionized water;

[0039] (2) Dissolve vitamin C, green tea extract EGCG and trehalose in deionized water and filter, sterilize by conventional high temperature, cool to below 25°C to obtain a mixed solution, and set aside;

[0040] (3) SOD is sterilized by conventional irradiation, and the sterilized SOD is added to the mixed solution prepared in step (2) in a sterile working environment, mixed and dissolved to obtain a mixed enzyme solution;

[0041] (4) Fill the mixed enzyme solution into a spray bot...

Embodiment 1

[0046] The antioxidant SOD oral spray described in this example comprises the following components by weight percentage: 0.1% superoxide dismutase (SOD), 1.0% vitamin C, 1.0% trehalose, and 0.2% green tea extract EGCG , the balance of deionized water.

[0047] The preparation method of above-mentioned antioxidant SOD oral spray, specifically comprises the following steps:

[0048] (1) Weigh the formula amounts of SOD, vitamin C, green tea extract EGCG, trehalose, and deionized water;

[0049] (2) Dissolve vitamin C, green tea extract EGCG and trehalose in deionized water and filter, sterilize by conventional high temperature, cool to below 25°C to obtain a mixed solution, and set aside;

[0050] (3) SOD is sterilized by conventional irradiation, and the sterilized SOD is added to the mixed solution prepared in step (2) in a sterile working environment, mixed and dissolved to obtain a mixed enzyme solution;

[0051] (4) Fill the mixed enzyme solution into a spray bottle with ...

Embodiment 2

[0054] The antioxidant SOD oral spray described in this example comprises the following components by weight percentage: 0.15% superoxide dismutase (SOD), 5.0% vitamin C, 3.5% trehalose, and 0.3% green tea extract EGCG , the balance of deionized water.

[0055] The preparation method of above-mentioned antioxidant SOD oral spray, specifically comprises the following steps:

[0056] (1) Weigh the formula amounts of SOD, vitamin C, green tea extract EGCG, trehalose, and deionized water;

[0057] (2) Dissolve vitamin C, green tea extract EGCG and trehalose in deionized water and filter, sterilize by conventional high temperature, cool to below 25°C to obtain a mixed solution, and set aside;

[0058] (3) SOD is sterilized by conventional irradiation, and the sterilized SOD is added to the mixed solution prepared in step (2) in a sterile working environment, mixed and dissolved to obtain a mixed enzyme solution;

[0059] (4) Fill the mixed enzyme solution into a spray bottle with...

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Abstract

The invention relates to an antioxidation SOD oral spray. The oral spray is prepared, by weight, 0.1-2.0% of superoxide dismutase (SOD), 1.0-5.0% of vitamin C, 1.0-3.5% of trehalose, 0.2-1.0% green tea extract and others is distilled water. The preparing method comprises the steps of 1, weighing each raw material of the formula ratio respectively; 2, dissolving the vitamin C, the green tea extract EGCG and the trehalose into the distilled water and filtering, adopting conventional high temperature sterilization method and cooling to below 25 DEG C to get mixed liquor; 3, adopting conventional radiation sterilization method for SOD and placing the sterilized SOD into the mixed liquor made in step of 2 under the sterile working environment, mixing and dissolving to get mixed enzyme solution; 4, canning the mixed enzyme solution into a spraying bottle with quantitative valves to get the antioxidation SOD oral spray and store the antioxidation SOD oral spray below 25 DEG C. The antioxidation SOD oral spray and preparing method thereof make use of mutual protection and interaction between the SOD and the vitamin C and between the green tea extract EGCG and the trehalose to make the oral spray with good stability, antioxidant and anti-aging functions. The oral spray is absorbed directly by the sublingual mucosa, conveniently to take, improving bioavailability and efficacy of SOD significantly with wide and broad market in future.

Description

technical field [0001] The invention relates to a health food, in particular to an anti-oxidation SOD oral spray and a preparation method thereof. Background technique [0002] Under the action of some damage factors, such as disease, trauma, environmental pollution, ion radiation, ultraviolet radiation, chemical drugs, etc., can induce the body to produce a large number of reactive oxygen species (ROS), which can cause cell membrane peroxidation and form A large amount of lipid peroxide (LPO) and its degradation product malondialdehyde (MDA) damage the normal membrane structure, increase permeability, swell mitochondria, directly attack nucleic acids, and cause cross-linking and breakage of DNA and RNA. Degeneration, which leads to the aging of the body and the occurrence of various diseases. [0003] Superoxide dismutase (SOD for short) is the most important antioxidant enzyme in the body to scavenge free radicals. Under the action of SOD, superoxide anion oxygen free rad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K9/12A61P39/06A23L33/00A23L33/10A23L33/105A23L33/125A23L33/15A61K31/7016A61K31/375A61K31/353
CPCA61K38/446A23V2002/00A61K9/006A61K31/353A61K31/375A61K31/7016C12Y115/01001A61K2300/00A23V2200/30A23V2200/302A23V2250/214A23V2250/636A23V2250/708
Inventor 陈石良
Owner 陈石良
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