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Mannan-binding lectin (MBL) in the treatment of immunocompromised conditions asssociated with cancer

A technology of mannan and lectin, applied in medical preparations containing active ingredients, antiviral agents, drug combinations, etc., can solve problems such as lack of susceptibility

Inactive Publication Date: 2008-06-04
内蒂穆恩公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

MBL deficiency is associated with susceptibility to various infections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0158] Tests for MBL

[0159] The concentration of MBL can be determined by time-resolved immunofluorescence assay (TRIFMA). Microtiter wells (fluoroNunc , Nunc, Kamstrup, Denmark) were coated with antibodies. Tween-containing buffer (TBS, 0.14M NaCl, 10mM Tris / HCl, 7.5mM NaN 3, pH 7.4, containing 0.05% Tween 20) After washing, test samples (plasma 1 / 20) in TBS / Tween with additional NaCl (to 0.5M) and 10 mM EDTA and calibration diluent were added.

[0160] After overnight incubation at 4°C and washing, a chromogenic europium-labeled antibody (12.5 ng Mab 131-1 in TBS / Tween containing 25 μM EDTA) was added containing Eu chelating agent benzoyl isothiocyanate-divinyl-triamine-tetraacetic acid labeling).

[0161] After 2 h incubation and washing, fluorescence enhancement solution (Wallac) was added and the plates were read on a time-resolved fluorometer (Delfia 1232, Wallac). A calibration curve was drawn using a standard plasma dilution, which was aliquoted and stored at -8...

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Abstract

The present invention pertains to the use of subunits and oligomers of mannan- binding lectin (MBL) in prophylactic and / or curative treatment of an immunocompromised individual such as subjects suffering from solid tumors or haematological cancers. Solid tumors include such as female cancers, male cancers, cancers of the respiratory system, cancers of the gastro intestinal system, the renal system and further subjects suffering from thyroid cancer and melanomas. Haematological cancers include leukaemia, lymphoma and myeloma. The immunocompromised condition of the individual may be due to a cancer disease as mentioned herein or the treatment of said cancer disease.

Description

technical field [0001] The present invention relates to the role of mannan-binding lectin (MBL) subunits and oligomers in the prophylactic and / or therapeutic treatment of immunocompromised individuals, such as those with solid tumors or hematological cancers. subjects). Solid tumors include, for example, cancers in women, cancers in men, cancers of the respiratory system, cancers of the gastrointestinal system, renal systems, and further, individuals with thyroid cancer and melanoma. Hematological cancers include leukemia, lymphoma, and myeloma. The immunocompromised condition in an individual may result from or treatment of a cancer disease as described herein. Background of the invention [0002] solid tumor [0003] Solid tumors are cancers of body tissues other than the blood, bone marrow, or lymphatic system. Examples of solid tumors include breast, prostate, and lung, bladder, kidney, colon, and thyroid cancers. Cancers that present as solid tumors can be divided ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17
CPCA61K38/1709A61P31/00A61P31/04A61P31/10A61P31/12A61P31/16A61P31/18A61P31/22A61P37/04
Inventor 马丁·邦德
Owner 内蒂穆恩公司
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