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Medicament for treating liver disease

A drug and liver disease technology, applied in the field of drugs for the treatment of early-stage liver cirrhosis, chronic hepatitis and liver fibrosis, can solve problems such as toxic side effects, methods and drugs lacking specific effects, etc.

Active Publication Date: 2012-05-09
BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment drugs for the advanced stage of early liver cirrhosis mainly include colchicine, prostaglandin E (PGE), interferon (Interferon), penicillinamine, and Malotile (Malotile), but Western medicine at home and abroad still does not treat it. Lack of effective methods and drugs
[0006] Among the above-mentioned drugs currently used in the treatment of liver diseases, most of the drugs have not achieved the expected clinical effect in clinical practice. Due to the limitations of western medicines against liver fibrosis, liver cirrhosis, and chronic hepatitis, most of them have toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 15 parts of astragalus, 15 parts of turtle shell, 10 parts of salvia miltiorrhiza, 10 parts of Ganoderma lucidum, 10 parts of chicken bone grass, 6 parts of Atractylodes macrocephala, 10 parts of red peony, 6 parts of Bupleurum

[0039] Add 10 times the amount of water to the above 8 flavors, Bupleurum and Atractylodes Rhizome, soak overnight, steam distill for 10 hours, extract the volatile oil, collect the distilled aqueous solution in another device, and keep the dregs for use; the volatile oil is clad with beta cyclodextrin (volatile oil-times Other cyclodextrin-water=1:6:80, stirred at 50°C for 1.0 hour), refrigerated overnight, filtered, dried at low temperature (40°C), and pulverized into fine powder; After decocting for 1.0 hour, mix with Ganoderma lucidum, add 10 times the amount of water to decoct 3 times, 2.0 hours each time, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.12 (60°C); With chicken bone ...

Embodiment 2

[0041] 5 parts of Astragalus, 5 parts of Turtle Shell, 3 parts of Salvia, 3 parts of Ganoderma lucidum, 3 parts of Jigucao, 2 parts of Atractylodes macrocephala, 3 parts of Radix Paeoniae Rubra, 2 parts of Bupleurum

[0042] Add 10 times the amount of water to the above 8 flavors, Bupleurum and Atractylodes Rhizome, soak for 2 hours, steam distill for 8 hours, extract the volatile oil, collect the distilled aqueous solution in another device, and keep the medicinal residues; the volatile oil is clad with beta cyclodextrin (volatile oil- Beta-cyclodextrin-water=1:8:80, stir at 50°C for 1.0 hour), refrigerate overnight, filter, dry the inclusions at low temperature (40°C), and grind them into fine powder; add 8 times the amount after the turtle shell is crushed After decocting in water for 2.0 hours, mix with the above-mentioned medicinal residues, ganoderma lucidum, chicken bone grass and red peony root, add water and decoct 4 times, the amount of water added is 12 times, 12 tim...

Embodiment 3

[0044] 25 parts of astragalus, 25 parts of turtle shell, 17 parts of salvia miltiorrhiza, 17 parts of Ganoderma lucidum, 17 parts of chicken bone grass, 10 parts of Atractylodes macrocephala, 17 parts of red peony, 10 parts of Bupleurum

[0045]For the above 8 flavors, crush the turtle shell and add 10 times the amount of water to decoct for 2.0 hours, mix it with Bupleurum, Atractylodes macrocephala, Ganoderma lucidum, chicken bone grass, and red peony root, add 15 times the amount of water each time to decoct for 5.0 hours, combine the decoction, filter After filtration, the filtrate was combined with the above aqueous solution, and concentrated appropriately; Radix Astragali and Danshen were extracted with 60% ethanol for 3 times, each time for 2.0 hours, the extracts were combined, filtered, and the filtrate recovered ethanol and concentrated, mixed with the above concentrated solution, filtered, Add carbomer, glycerin, and potassium sorbate to the filtrate, stir to dissolv...

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Abstract

The invention relates to a medicament for treating hepatosis, and the effective constituents of the medicament is made by crude drugs of Astragalus root, carapax amydae, red sage root, ganoderma lucidum, chicken-bone herb or stringy stonecrop or phyllanthus, Atractylis ovata, radices paeoniae rubra and radix bupleuri; the crude drugs can be made into various oral preparations and external preparations by proper treatment and / or adding acceptable supplementary materials in pharmaceutics; and the medicament of the invention can benefit the vital energy and disperse the depressed liver-energy aswell as promoting blood flow and softening hard mass, so the invention is mainly used for the treatment of early cirrhosis, chronic hepatitis and hepatic fibrosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine, in particular to a medicine for treating early liver cirrhosis, chronic hepatitis and liver fibrosis, which contains traditional Chinese medicines such as astragalus, turtle shell and salvia miltiorrhiza. Background technique [0002] Chronic hepatitis refers to a chronic inflammatory disease of the liver with a course of more than half a year. Liver fibrosis refers to abnormal hyperplasia of fibrous connective tissue in the liver, which is mostly caused by persistent liver injury or the presence of stimulating factors that promote fibrosis. Liver cirrhosis is a chronic, progressive and diffuse change in the liver caused by various reasons. Early liver cirrhosis refers to no specific clinical symptoms or signs, no obvious abnormalities in liver function tests, but obvious changes in liver histology. pathological changes. Chronic hepatitis B is a major risk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/53A61K36/481A61K36/48A61K36/284A61K36/233A61K36/074A61K35/56A61P1/16A61K35/586
Inventor 张保献
Owner BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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