Gene chip for gynecologic malignant tumor early screening and detection method thereof

A malignant tumor and gene chip technology, which is applied in the field of gene chip and its detection for the early screening and diagnosis of common gynecological malignant tumors, can solve the problems of inability to conduct general surveys, early diagnosis of tumor patients, poor specificity, etc., and achieve simple sampling and maintenance Consistency, easy general sieving effect

Inactive Publication Date: 2008-07-30
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the early diagnosis of tumors mainly uses the detection of tumor markers, but due to its poor specificity, it is difficult to carry out early diagnosis of tumor patients, and it is impossible to conduct general surveys among the whole population.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Blood samples from several cancer patients were collected, and prepared into oligonucleotide gene chips by Gene Company according to the aforementioned requirements.

Embodiment 2

[0036] Take 5ml of patient A's blood and extract a blood gene sample, and hybridize the sample gene with the oligonucleotide gene chip. The hybridization results obtained from the detection show that the expression of VEGFA (M27281), IGF1 (NM_000618), and LTA (NM_000595) in A's blood is up-regulated , which means that patient A is likely to suffer from breast cancer.

Embodiment 3

[0038] Take 5ml of patient B's blood and extract a blood gene sample, and hybridize the sample gene with the oligonucleotide gene chip. The hybridization results obtained by detection show that the expression of RASSF1 (NM_007182) is down-regulated and the expression of CD44 (X55150) is up-regulated in B's blood, which means that Patient B is likely to have ovarian cancer.

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PUM

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Abstract

The invention provides a method of manufacturing an oligonucleotide gene chip for screening and diagnosing the normally gynecological malignant tumor in early phase and the method of detecting the same. The method uses the related genes of normally gynecological malignant tumor (breast cancer, ovarian cancer and uterine cancer) as control, and determines whether the patient has the malignant tumor by manufacturing the oligonucleotide and chip hybridizing and detecting. The invention provides a detecting method of screening and diagnosing the normally gynecological malignant tumor in early phase based on gene chip, which makes the characteristic gene of the normally gynecological malignant tumor into a gene chip so as to keep the consistence of the clinic detecting condition. The method can screen and diagnose the normally malignant tumor ASAP. With convenience in sampling and good consistence, the method of the invention is prone to popularize; by proper application, the cancer mortality can be reduced by 1/3.

Description

technical field [0001] The invention relates to an early screening method for common gynecological malignant tumors (breast cancer, ovarian cancer, and uterine cancer), in particular to a gene chip for early screening and diagnosis of common gynecological malignant tumors and a detection method thereof. Background technique [0002] Malignant tumors (including lung cancer, breast cancer, colorectal cancer, gastric cancer, and cervical cancer) are common diseases that seriously endanger human life and health. According to the statistics of the World Health Organization, there are 4.9 million new cancer patients and 4.3 million deaths every year in the world, and one out of every 10 people dies of cancer. Malignant tumors are one of the three major causes of death in humans, second only to heart and cerebrovascular diseases. [0003] In addition to actively doing a good job in etiology, the prevention and treatment of cancer is mainly "three early" measures, namely early dete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 陈勇谭秋萍朱文婷张晓雷王恒松韩凤梅
Owner HUBEI UNIV
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