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Compositions comprising an no donor and a dithiolane and their use for improvement of sexual function

A technology of nitric oxide and dithiolane is applied in excess based on the molar amount of the part. field, able to address issues such as improving treatment methods

Active Publication Date: 2008-08-06
英柯瑞普塔有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] In conclusion, there is currently no good treatment without serious side effects for improving sexual function or treating sexual dysfunction in both men and women

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] α-lipoic acid choline

[0085] Packaged in polyethylene terephthalate bottles of 200ml and stored at 4°C.

Embodiment 2

[0087] R(+-)α-lipoic acid trometamol (R(+-)α-

[0088] Packaged in polyethylene terephthalate bottles of 200ml and stored at 4°C.

Embodiment 3

[0090] alpha-lipoic acid

[0091] Packaged in polyethylene terephthalate bottles of 200ml and stored at 4°C.

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PUM

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Abstract

The present invention relates to solid compositions comprising a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide or an direct or indirect NO agonist, with arginine being a preferred compound, in combination with a dithiolane, with ±-lipoic acid as a preferred compound, and its use for improvement of sexual function. The compositions according to the invention comprise the NO donor or its precursor in excess, based on the molar amount of the constituents. The compositions are also suited for the improvement of sexual function. In particular the present invention relates to the use of a dithiolane in combination with a NO donor or a precursor thereof for the preparation of a medication for treatment of sexual dysfunction.

Description

technical field [0001] The present invention relates to solid compositions comprising a substance improving the availability of nitric oxide, such as a nitric oxide donor or its biosynthetic nitric oxide precursor or a direct or indirect nitric oxide potentiator, Among them, arginine is the preferred compound, and combined with dithiolane, wherein the dithiolane is the preferred compound with α-lipoic acid, and this composition can be used to improve sexual function. According to the invention, the composition comprises a nitric oxide donor or a precursor thereof in excess based on the molar amount of the ingredients. This composition is also suitable for improving sexual function. In particular, the present invention relates to the use of dithiolane in combination with nitric oxide donors or their precursors as a pharmaceutical treatment for sexual dysfunction. Background technique [0002] Sexual function is an important biological and social factor in adult life. It ai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/385A61P15/10A61P15/12A61P15/00
CPCA61K31/385A61K31/198A61P15/00A61P15/08A61P15/10A61P15/12A61P43/00
Inventor 克劳斯·韦塞尔
Owner 英柯瑞普塔有限公司
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