Dual sustained-release anticancer injection

Abstract

A double sustained release anticancer gel sustained release injection consists of anticancer medicine and amphiphilic block copolymer hydrogel, wherein the anticancer medicine comprises vincristine, vinorelbine, vinblastine, daunomycin, mitoxantrone, mitozolomide and temozolomide, etc., and exists in sustained release preparation injection in the forms of sustained release microsphere, microsphere or micropowder, i.e. the anticancer medicine in anticancer useful quantity is partly or completely wrapped inside the sustained release microsphere. Sustained release gel has temperature-sensitive gelling characteristics and is in the state of fluxible liquid in an environment with the temperature lower than body temperature; moreover, the sustained release gel can be automatically converted into non-flowing water-insoluble gel capable of biodegradation and absorption inside the body of a warm blood so as to slowly release medicine inside part of a tumor; the sustained release microsphere is propitious to release medicine smoothly and slowly, and double sustained release is propitious to control tumor cells entering a dormancy stage; moreover, the medicine which exists in the sustained release gel in the form of micropowder is propitious to release the medicine relatively faster and to control cells in faster proliferation. The double sustained release anticancer gel sustained release injection can used together with radiotherapeutic particle, etc.

Description

(1) Technical field

[0001] The invention relates to a double slow-release anticancer gel injection, which belongs to the technical field of medicines. Specifically, the invention relates to a slow-release gel preparation capable of stably releasing anticancer drugs in local solid tumors, mainly a slow-release gel injection containing slow-release microspheres. It is an aqueous solution, which can become a semi-solid or solid gel in the body of a warm-blooded animal. The slow-release gel and slow-release microspheres can slowly release anticancer drugs locally on the tumor for several months. (2) Background technology

[0002] Although there are many ways to treat cancer, the living conditions of most patients have not been significantly improved. Among the various treatments, chemotherapy remains one of the commonly used options. Although conventional chemotherapy has been used for a long time, its therapeutic effect on solid tumors is uncertain. The fundamental problem is...

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