Compound sustained-released injection containing neonatal blood vessel restraining agent

Abstract

The invention relates to a compound sustained-release injection containing neovascularization inhibitors, which comprises sustained-release microspheres and a solvent; wherein, the sustained-release microspheres comprise sustained-release auxiliary materials, neovascularization inhibitors which are selected from Marimastat or fumagillin, etc., and cytotoxic drugs which are selected from hydroxycamptothecine, Mitozolomide, 4-carboxy temozolomide, docetaxel, oxaliplatin, hetaplatin, isophosphamide, lomustine, estramustine, fotemustine, samustine, etoposide, teniposide, catharanthine, anastrozole, fluorouracil, or mitomycin C; the solvent is a special solvent containing a suspending agent. The sustained-release auxiliary materials are selected from decanedioic acid copolymers such as Polifeprosan, polylactic acid, poly (erucic acid dimmer-decanedioic acid) and poly (fumaric acid-decanedioic acid) and so on, EVAc, etc.; the viscosity of the suspending agent ranges from 100cp to 3000cp (when the temperature is 25 to 30 DEG C), and the suspending agent is selected from sodium carboxymethyl cellulose, etc. The sustained-release microspheres can also be made into a sustained-release implanting agent, and can increase the curative effects of the non-operative treatments such as radiotherapy and chemotherapy, etc. when being injected or put in or around tumors.

Description

(1) Technical field

[0001] The invention relates to a compound slow-release agent containing angiogenesis inhibitor and a preparation method thereof, belonging to the technical field of medicines. Specifically, the present invention provides a slow-release preparation of anticancer drugs containing angiogenesis inhibitors and / or cytotoxic drugs, mainly slow-release injections and slow-release implants. (2) Background technology

[0002] Angiogenesis is necessary for the growth and metastasis of solid tumors. When the diameter of solid tumor is larger than 0.5em, tumor cells depend on their own vascular system. Tumor cells can obtain nutrients and oxygen from the host through tumor blood vessels, and can continuously transport metastatic cells to the host through tumor blood vessels, and continue to grow and induce blood vessel formation in other parts of the body, leading to tumor metastasis. The emergence of new metastases is the main reason for treatment failure. Theref...