Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof

A composition and platelet technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as uncertain curative effect, no standardized treatment plan, and does not meet the development requirements of traditional Chinese medicine, etc., to achieve platelet production and Effects of increased release, reduced capillary fragility, and prevention of bleeding tendency

Active Publication Date: 2010-12-29
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The efficacy of these drugs is uncertain, with considerable metabolic or carcinogenic adverse consequences
The latest Rituximab (anti-CD20 monoclonal antibody) can achieve a curative effect of 44% to 55.1%, but it is still prone to recurrence and expensive
There are many reports on the treatment of ITP with traditional Chinese medicine, but there are not many definite curative effects. Most of them are clinical observations with small samples. Especially for refractory ITP (RITP), there is no effective prevention and treatment drug, and there is no standardized treatment plan. Large-sample research failed to strictly follow the requirements of Evidence-Based Medicine (EBM), which made the conclusions lack of scientificity and reliability, and was not conducive to popularization and application, and did not meet the development requirements of modern Chinese medicine.

Method used

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  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof
  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof
  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0149] The preparation of granule of the present invention:

[0150] Weigh the following raw materials (g): 240 raw Radix Astragali, 200 Ligustrum lucidum, 120 raw Atractylodes macrocephala, 120 fried white peony, 200 Zhishouwu, 150 dodder, 120 fried Danpi, 60 fried Citrus aurantium, 300 Agrimony, Panax notoginseng 150, forsythia 150, licorice 60.

[0151] The preparation method is:

[0152] The above-mentioned traditional Chinese medicine is formulated according to the components by weight, and the decoction pieces are soaked in water, and decocted twice with water. Fry for 2 hours after reaching the boiling point for the first time, and then fry for 1 hour after reaching the boiling point for the second time. Discard the residue and filter and combine the two filtrates, settle for 12 hours, take the supernatant and concentrate it into a thick paste, add 50% white dextrin and appropriate amount of stevioside , 60 ℃ low temperature, concentrated into a dry cream powder, made...

Embodiment 2

[0154] The preparation of oral liquid of the present invention:

[0155] Weigh the following raw materials (g): 240 raw Radix Astragali, 200 Ligustrum lucidum, 120 raw Atractylodes macrocephala, 120 fried white peony root, 200 Zhishouwu, 150 dodder, 120 fried paeonol, 60 fried Citrus aurantium, 300 Agrimony, Panax notoginseng 150, forsythia 150, licorice 60.

[0156] The preparation method is:

[0157] The above-mentioned traditional Chinese medicine is formulated according to the components by weight, and the decoction pieces are soaked in water, and decocted twice with water. After reaching the boiling point for the first time, fry for 1 hour, and then fry for 0.5 hours after reaching the boiling point for the second time, discard the dregs, filter and combine the two filtrates, let it settle for 12 hours, take the supernatant and concentrate to an appropriate amount, add sucrose and preservatives while hot Stir well to make the full amount, and distribute it in 200ml bott...

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Abstract

The invention relates to a medicine composition for treating idiopathic thrombocytopenic purpura and a preparation method thereof. The medicine composition comprises the following composition raw material preparations: raw astragalus, ligustrum lucidum, raw rhizoma atractylodis, fried white peony root, radix polygoni multiflori preparata, dodder, fried cortex moutan, fried bitter orange, agrimony, aizoon stonecrop, forsythia and roasted glycyrrhiza; granules or oral liquid can be prepared by the method of the invention; and the medicine composition prepared by the method of the invention has the advantages of safety, effectiveness, stability and economy, is suitable for Chinese basic conditions and can be popularized and applied.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating idiopathic thrombocytopenic purpura and a preparation method thereof, in particular to a pharmaceutical composition for treating idiopathic thrombocytopenic purpura prepared from traditional Chinese medicines and a preparation method thereof. Background technique [0002] Idiopathic thrombocytopenia purpura (Idiopathic thrombocytopenia purpura, ITP) is a syndrome of increased destruction of platelets due to immune mechanism. This disease is a common disease of the blood system, accounting for about 70% of hemorrhagic diseases, often recurrent, lingering and difficult to heal, and may be life-threatening due to concurrent intracranial hemorrhage and severe internal hemorrhage. [0003] Glucocorticoid is the drug of choice for the treatment of this disease. The short-term effective rate is 60-80%, and the long-term remission rate is only 10-15%. Moreover, the toxic and side effects caused...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/75A61K9/16A61K9/10A61P7/04
Inventor 周永明黄振翘李峻
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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