Flux limiting membrane for intravenous amperometric biosensor

A biosensor, flow-limiting technology, applied in the field of galvanometer biosensors, can solve problems such as obstruction of venous galvanometer sensors

Inactive Publication Date: 2009-02-04
EDWARDS LIFESCIENCES CORP
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] One of the challenges holding back venous galvanometry sensors is that the sensor must be small enough to be suspended within a blood vessel, but robust enough to immobilize the enzyme to sustain the reaction long enough

Method used

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  • Flux limiting membrane for intravenous amperometric biosensor
  • Flux limiting membrane for intravenous amperometric biosensor
  • Flux limiting membrane for intravenous amperometric biosensor

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Embodiment Construction

[0018] The present invention discloses bonded biocompatible polymers for use in forming flux-limiting membranes on enzyme-carrying electrodes within venous amperometric biosensors. When the sensor is placed in a patient for measuring blood chemistry, the membrane improves the accuracy of the sensor by allowing oxygen to pass from the blood to the sensor while limiting the transfer of larger molecules. The biocompatibility of the membrane limits the amount of toxins that could be introduced into the bloodstream, and the adhesive properties improve the mechanical integrity of the sensor during implantation and operation.

[0019] In one embodiment, the membrane can be used on a glucose sensor for limiting the flux of glucose from the blood to the sensor electrodes. The biocompatible polymer forming the film may contain an optimal content of dissolved ethylene vinyl acetate (EVA). A solvent such as p-xylene can be used to dissolve the EVA into a solution suitable for application...

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Abstract

A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.

Description

[0001] Claim Priority Pursuant to 35 U.S.C. §119 [0001] This application for patent claims priority to US Provisional Application 60 / 777,139, filed February 27, 2006, which is hereby assigned to the assignee, which is hereby expressly incorporated by reference. technical field [0002] The present invention relates to amperometric biosensors for measuring blood chemistry. In particular, the present invention relates to venous sensors for measuring biological parameters such as blood glucose concentration. Background technique [0003] Amperometric biosensors are known in the medical industry for analyzing blood chemistry. Early biosensors - also known as enzyme electrodes - were first proposed by Clark and Lyons and implemented by Updike and Hicks. Enzyme electrodes typically include an oxidase, such as glucose oxidase, immobilized beneath a dialysis membrane on the surface of the electrode. In the presence of blood, the membrane selectively passes the analyte of intere...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00C12Q1/00
CPCA61B5/14865A61B5/14532
Inventor K·M·柯里
Owner EDWARDS LIFESCIENCES CORP
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