Transgenosis construct and application thereof in preparing space-time adjustable liver damage model

A technology for liver damage and constructs, which is applied to cells modified by the introduction of foreign genetic material, introduction of foreign genetic material using vectors, animal husbandry, etc.
CN101684476BInactive Publication Date: 2012-05-02SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a transgenosis construct and an application thereof in preparing a space-time adjustable liver damage model and discloses a construct combination used for preparing the space-time adjustable liver damage model. The construct combination comprises a construct expressing space-time adjustable liver damage induction induced gene and a construct expressing Cre recombinant enzyme. The invention also discloses cells containing the construct and a method for preparing the space-time adjustable liver damage model. The obtained animal model can efficiently induce the liver damage at any time, and provides an effective way for the research of hepatic cell transplantation and liver replantation.
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Description

Technical field

[0001] The invention belongs to the field of biotechnology, and specifically relates to a transgenic construct and its application in preparing a spatiotemporal adjustable liver injury model. Background technique

[0002] Liver organ transplantation is currently the main method for clinical treatment of acute liver failure, end-stage liver disease and metabolic liver disease. However, due to the shortage of donor livers, the clinical application of liver organ transplantation has been severely restricted. Approximately 14,000 people in the United States wait for liver transplantation each year, of which 50% wait for more than one year, and about 1,300 people die each year because they cannot wait for liver transplantation. The waiting list for organ transplantation in our country is also increasing. Therefore, other clinical methods are urgently needed to improve liver function, extend the survival time of patients to wait for liver transplantation, or replace l...

Claims

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