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Traditional Chinese medicine monomer having function of promoting growth of motoneuron

A technology of motor nerves and monomers, applied to nervous system diseases, medical preparations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2011-05-04
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Motor neuron disease is a chronic, fatal degenerative disease of the nervous system for which there is currently no cure

Method used

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  • Traditional Chinese medicine monomer having function of promoting growth of motoneuron
  • Traditional Chinese medicine monomer having function of promoting growth of motoneuron
  • Traditional Chinese medicine monomer having function of promoting growth of motoneuron

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] 1. Drug function verification at the cellular level

[0022] After the drugs were applied to the primary cultured motor neurons for 24 hours, the axonal growth of the neurons was observed under an inverted microscope. There were 3 wells in each group, and several fields of view were randomly selected in each well to take pictures. The length of the statistical process was measured by IPP software. Values ​​were compared with the PBS control group to evaluate the effect of drugs on the length of motor neuron neurite ( figure 2 ). Next, the length of motor neuron axons at different concentrations of various traditional Chinese medicine monomers were counted, and it was found that the five drugs can all promote the growth of neuron neurites at a certain concentration, and there is a significant difference compared with PBS. difference( image 3 ).

[0023] 2. Drug function verification from the whole animal level

[0024] The sciatic nerve and femoral nerve were clamp...

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Abstract

The invention belongs to the research and development field of neuro-protective medicament, and discloses a traditional Chinese medicine monomer capable of promoting growth of motoneuron. In the aspect of isolated cell level, the traditional Chinese medicine compound, can obviously promote enation of motoneuron; in the aspect of integral animal level, the compound can obviously promote functional rehabilitation of impaired sciatic nerve and femoral nerve. The invention can be applied to medicinal development for amyotrophic lateral sclerosis and relevant motoneuro symptoms.

Description

Technical field: [0001] The invention relates to the field of research and development of neuroprotective drugs, in particular, Chinese medicine monomers and derivatives thereof that can be used to treat motor neuron damage and related diseases have been found from traditional Chinese medicines. Background technique: [0002] Motor neuron disease is a chronic fatal degenerative disease of the nervous system, and there is currently no cure for it. But since motor neurone disease was discovered more than 100 years ago, people have been fighting it and tried nearly 100 drug treatments. With the development of neuroscience and the in-depth understanding of the etiology and pathophysiology of MND, people have made a series of remarkable achievements in the challenge of this intractable disease. The current main treatment includes etiological treatment, symptomatic treatment and a variety of non-drug supportive treatment. The development direction of treatment research at this s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/352A61P25/02A61P25/28
Inventor 廖红秦靖殷志琦张陆勇
Owner CHINA PHARM UNIV
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