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Composition for preparing external preparation for treating soft tissue injuries and preparation method thereof

A soft tissue injury and external preparation technology, which is applied in the field of orthopedic diseases and can solve problems such as demulsification, insufficient product viscosity, and oil-water separation.

Active Publication Date: 2013-04-24
ZHEJIANG APELOA KANGYU PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Without a thickener, the obtained product has insufficient viscosity and cannot be squeezed out into strips in a hose. It is easy to drip and pollute clothes during use, which brings inconvenience to patients.
[0008] (3) The stability is poor, and oil and water will separate in summer, resulting in demulsification
In the technical scheme of the invention of CN1939480A, the antiseptic ethylparaben is oil-soluble, and the solubility in the water phase is relatively low

Method used

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  • Composition for preparing external preparation for treating soft tissue injuries and preparation method thereof
  • Composition for preparing external preparation for treating soft tissue injuries and preparation method thereof
  • Composition for preparing external preparation for treating soft tissue injuries and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1: Cream formulation process I

[0067] Raw materials (calculated as 1000g ointment):

[0068] Maodongqing 62.5g Aralia 65.2g Rectangular leaf rat thorn root 37.5g

[0069] Cinnabar root 75g Trifolium phoebe root 25g Earthworm 25g

[0070] Yellow eargrass 50g Masson pine root 62.5g Snake grape root 75g

[0071] Palm tree root 100g Sophora flavescens 87.5g Golden lamp vine 50g

[0072] Rhizoma Drynaria 37.5g Salicaria root 37.5g Piercing Stone 50g

[0073] Extraction process:

[0074] Crush the fifteen-flavored raw materials into coarse powder, moisten them evenly with 75% ethanol, keep them tightly closed for 2 hours, and then put them into the percolator. The filling should be nearly uniform and tight. Add 75% ethanol for soaking 2 Hours, then start percolation, collect 8 times the amount of medicinal materials, concentrate the liquid to a clear ointment with a relative density of 1.10~1.15 (85℃), filter, and use the filtrate for later use; add 6 times the amount of medic...

Embodiment 2

[0089] Example 2: Cream formulation process II

[0090] Raw materials (calculated as 1000g ointment): the same as in Example 1.

[0091] Extraction process:

[0092] Cut the fifteen-flavored raw materials into sections, and extract them with 10 times the amount of 60% ethanol at reflux for 2 hours. The extract is concentrated to a clear cream with a relative density of 1.10~1.15 (85°C), filtered, and the filtrate is ready for use; Add 6 times the amount of medicinal materials and decoct the dregs twice for 1 to 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear cream with a relative density of 1.05 to 1.10 (85°C), filter, and use the filtrate for use .

[0093] Medicinal carrier (calculated as 1000g ointment):

[0094] Carbomer 1g Polyoxyethylene fatty alcohol ether (OLI-9022) 5g

[0095] Glyceryl monostearate 50g liquid paraffin 110g

[0096] Yellow Vaseline 5g Sodium Hydroxide

[0097] Gema BP3g

[0098] Formulation process:

[0099] ① Take carbome...

Embodiment 3

[0107] Example 3: Cream formulation process III

[0108] Raw materials (calculated as 1000g ointment):

[0109] Maodongqing 30g Aralia 30g rectangular leaf rat thorn root 19g

[0110] Cinnabar root 37g Trifolium phoebe root 13g Dilong 13g

[0111] Yellow Ear Grass 25g Masson Pine Root 30g Snake Grape Root 150g

[0112] Flower palm tree root 200g Sophora flavescens 175g golden lamp vine 100g

[0113] Rhizoma Drynaria 75g Salicaria root 75g Perforating stone 100g

[0114] Extraction process:

[0115] Crush the 15-flavored raw materials into coarse powder, add 10 times the amount of the medicinal materials to 95% ethanol for 24 hours, concentrate the dipping liquid to a clear ointment with a relative density of 1.10~1.15 (85℃), filter, and use the filtrate for use; The residue is decocted twice with 6 times the amount of medicinal material in water for 1 to 2 hours each time. The decoction is combined, filtered, and the filtrate is concentrated to a clear cream with a relative density of 1....

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Abstract

The invention relates to an external preparation for treating soft tissue injuries, belonging to the technical field of medicaments for treating orthopedic diseases. The external preparation is prepared from a water or alcohol extract of raw material medicines and pharmaceutically acceptable carriers. The raw material medicines comprise pubescent holly roots, Chinese aralis, oblongleaf Chinese sweetspire roots and flowers, ardisia crenata, syzygium grijsii roots, goldhair hedyotis herbs, earthworms, rinus massoniana roots, ampelopsis sinica roots, ormosia henryi roots, kuh-seng, cuscuta japonica, drynaria rhizome, thinleaf adina fruit roots and cudrania cochinchinensis. The carriers comprise oleaginousbase, an emulsifier and a preservative, wherein the weight percentage of the oleaginousbase is 10-21 percent, and the oleaginousbase is selected from one or a mixture of glyceryl monostearate, hexadecanol-octadecanol, vaseline and liquid paraffin; the weight percentage of the emulsifier is 0.5-5 percent, and the emulsifier is a polyoxyethylene fatty alcohol ether non-ionic emulsifier compound; the preservative is Jemaa BP accounting for 0.05-1.0 percent of the total weight of the preparation. The external preparation eliminates the irritability and the foreign odor of preparations of the prior art, obviously improves the viscosity of paste and improves the stability of emulsifiable paste.

Description

Technical field [0001] The invention belongs to the technical field of medicines for treating orthopedic diseases, and particularly relates to a traditional Chinese medicine compound external preparation for treating local swelling, blood stasis, pain, dysfunction and other diseases caused by human soft tissue injury. Background technique [0002] Soft tissue injury is a common and frequently-occurring disease in Orthopedics and Traumatology, and it belongs to the category of "muscles and tendons" in the dialectics of Chinese medicine. External violence such as falls, impacts, falls, frustrations, crushing, twisting, etc. directly or indirectly affect the body, causing the body's skin, subcutaneous tissue, fascia, muscles, tendon ligaments, periosteum, joint capsule, synovial sac, etc. A series of pathological changes occurred in the injury of the site. The clinical manifestations are local pain, tenderness, swelling, bruising, ecchymosis, and physical dysfunction. The main tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K9/107A61K9/00A61K36/87A61K35/62A61K47/06A61K47/10
Inventor 葛萌芽葛永进王汉波吴叶锋
Owner ZHEJIANG APELOA KANGYU PHARMA
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