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External preparation for treating soft tissue injuries and preparation method thereof

A soft tissue injury and external preparation technology, which is applied in the field of orthopedic diseases and can solve problems such as demulsification, insufficient product viscosity, and oil-water separation.

Active Publication Date: 2010-04-14
ZHEJIANG APELOA KANGYU PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (2) Without a thickener, the obtained product has insufficient viscosity and cannot be squeezed out into strips in a hose. It is easy to drip and pollute clothes during use, which brings inconvenience to patients.
[0008] (3) The stability is poor, and oil and water will separate in summer, resulting in demulsification
In the technical scheme of the invention of CN1939480A, the antiseptic ethylparaben is oil-soluble, and the solubility in the water phase is relatively low

Method used

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  • External preparation for treating soft tissue injuries and preparation method thereof
  • External preparation for treating soft tissue injuries and preparation method thereof
  • External preparation for treating soft tissue injuries and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: Ointment prescription technology I

[0068] Raw medicinal materials (calculated as 1000g ointment):

[0069] Hairy holly 62.5g Aralia 65.2g Rectangular leaf rat thorn root 37.5g

[0070] Cinnabar Root 75g Three-leaf Chinan Root 25g Dilong 25g

[0071] Yellow hair ear grass 50g Masson pine root 62.5g snake grape root 75g

[0072] Flower palm root 100g Sophora flavescens 87.5g Golden lantern vine 50g

[0073] Rhizoma drynaria 37.5g, plum root 37.5g, piercing stone 50g

[0074] Extraction process:

[0075] Grind the 15-flavor raw medicinal materials into coarse powder, moisten them evenly with 75% ethanol, place them in a sealed container for 2 hours, and then put them into a percolator. hours, then start percolating, collect 8 times the amount of medicinal material, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (85°C), filter, and use the filtrate for later use; add 6 times the amount of medicinal material to the d...

Embodiment 2

[0090] Embodiment 2: Ointment prescription process II

[0091] Raw medicinal materials (based on making 1000g ointment): with embodiment 1.

[0092] Extraction process:

[0093] Cut the 15-flavor raw medicinal materials into sections, heat reflux extraction with 60% ethanol which is 10 times the amount of medicinal materials, and extract for 2 hours, concentrate the extract to a clear paste with a relative density of 1.10-1.15 (85°C), filter, and use the filtrate for later use; Decoct the dregs with 6 times the amount of medicinal materials in water for two times, 1-2 hours each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.05-1.10 (85°C), filter, and use the filtrate for later use .

[0094] Medicinal carrier (based on 1000g ointment):

[0095] Carbomer 1g Polyoxyethylene fatty alcohol ether (OLI-9022) 5g

[0096] Glyceryl monostearate 50g liquid paraffin 110g

[0097] Yellow Vaseline 5g Sodium Hydroxide App...

Embodiment 3

[0108] Embodiment 3: Ointment prescription process III

[0109] Raw medicinal materials (calculated as 1000g ointment):

[0110] Hairy holly 30g Aralia 30g Rectangular leaf rat thorn root 19g

[0111] Cinnabar Root 37g Three-leaf Chinan Root 13g Dilong 13g

[0112] Yellow hair grass 25g Masson pine root 30g Snake grape root 150g

[0113] Flower palm root 200g Sophora flavescens 175g Golden lamp vine 100g

[0114] Rhizoma drynaria 75g, plum root 75g, piercing stone 100g

[0115] Extraction process:

[0116] Grind the fifteen herbs into coarse powder, add 10 times the amount of medicinal materials and 95% ethanol and soak for 24 hours, concentrate the soaking solution to a clear paste with a relative density of 1.10-1.15 (85°C), filter, and use the filtrate for later use; Add 6 times the amount of medicinal materials to the residue and decoct twice, 1-2 hours each time, combine the decoctions, filter, concentrate the filtrate to a clear paste with a relative density of 1....

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Abstract

The invention relates to an external preparation for treating soft tissue injuries, belonging to the technical field of medicaments for treating orthopedic diseases. The external preparation is prepared from a water or alcohol extract of raw material medicines and pharmaceutically acceptable carriers. The raw material medicines comprise pubescent holly roots, Chinese aralis, oblongleaf Chinese sweetspire roots and flowers, ardisia crenata, syzygium grijsii roots, goldhair hedyotis herbs, earthworms, rinus massoniana roots, ampelopsis sinica roots, ormosia henryi roots, kuh-seng, cuscuta japonica, drynaria rhizome, thinleaf adina fruit roots and cudrania cochinchinensis. The carriers comprise oleaginousbase, an emulsifier and a preservative, wherein the weight percentage of the oleaginousbase is 10-21 percent, and the oleaginousbase is selected from one or a mixture of glyceryl monostearate, hexadecanol-octadecanol, vaseline and liquid paraffin; the weight percentage of the emulsifier is 0.5-5 percent, and the emulsifier is a polyoxyethylene fatty alcohol ether non-ionic emulsifier compound; the preservative is Jemaa BP accounting for 0.05-1.0 percent of the total weight of the preparation. The external preparation eliminates the irritability and the foreign odor of preparations of the prior art, obviously improves the viscosity of paste and improves the stability of emulsifiable paste.

Description

technical field [0001] The invention belongs to the technical field of drugs for treating orthopedic diseases, in particular to a compound external preparation of traditional Chinese medicine for treating local swelling, blood stasis, pain, dysfunction and other diseases caused by human soft tissue damage. Background technique [0002] Soft tissue injury is a common and frequently-occurring disease in orthopedics and traumatology, and belongs to the category of "muscle injury" in the dialectical medicine of the motherland. Mostly due to external violence such as falls, impacts, falls, flashbacks, crushing, and wrestling, which directly or indirectly act on the body, resulting in damage to the body's skin, subcutaneous tissue, fascia, muscles, tendons, ligaments, periosteum, joint capsule, synovial bursa, etc. A series of pathological changes occurred in the injury site. The clinical manifestations are local pain, tenderness, swelling, bruising and ecchymosis, and dysfunctio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61K9/06A61K9/107A61K9/00A61K47/44A61K47/34A61P29/00A61P19/00A61K35/64A61K35/62A61K47/06A61K47/10
Inventor 葛萌芽葛永进王汉波吴叶锋
Owner ZHEJIANG APELOA KANGYU PHARMA
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