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Production technology of mesalazine oral liquid

A kind of technology of salazine oral liquid and production process, which is applied in the direction of dispersion liquid delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of slow therapeutic effect of mesalazine oral liquid and inability of diabetic patients Normal use, affecting the patient's health and other problems, to achieve the effect of preventing liver damage, eliminating tissue allergy, and protecting the liver

Inactive Publication Date: 2020-09-22
HANGZHOU BROTHER BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After the existing mesalamine oral liquid is eaten for a long time, the content of alanine aminotransferase in the patient's liver is gradually increasing, and it will cause the alanine aminotransferase to exceed the standard and then affect the health of the patient, and the therapeutic effect of the mesalamine oral liquid is relatively low. Slow, some oral liquids add sucrose to improve the taste, making it impossible for diabetic patients to use it normally, thus reducing the scope of application

Method used

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  • Production technology of mesalazine oral liquid

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Effect test

Embodiment 1

[0031] A production process of mesalazine oral liquid. The mesalazine oral liquid is made of the following raw materials in parts by weight: 10 parts of mesalamine, 5 parts of Scutellaria baicalensis extract, 5 parts of Coptidis Rhizoma extract, 5 parts of Poria cocos extract, fresh 10 parts of yam, 1.5 parts of citric acid, 3 parts of stevia, 20 parts of deionized water;

[0032] The production technology of this mesalamine oral liquid comprises the steps:

[0033] Step S1: Cut the fresh yam into pieces, squeeze the blocky yam, filter and remove the filter residue to obtain yam juice, add ethanol solution to the yam juice and mix until uniform, let stand for 2 hours, distill and remove the ethanol solution, Concentrate to a relative density of 1.5, and dry to obtain a dried Chinese yam paste;

[0034] Step S2: add Scutellaria baicalensis extract, Coptis chinensis extract, Poria cocos extract, yam dry paste prepared in step S1, and deionized water into the reaction kettle, an...

Embodiment 2

[0049] A production process of mesalazine oral liquid. The mesalamine oral liquid is made of the following raw materials in parts by weight: 15 parts of mesalazine, 6 parts of Scutellaria baicalensis extract, 6 parts of Coptidis Rhizoma extract, 6 parts of Poria cocos extract, fresh 13 parts of yam, 1.8 parts of citric acid, 4 parts of stevia, 25 parts of deionized water;

[0050] The production technology of this mesalamine oral liquid comprises the steps:

[0051] Step S1: Cut the fresh yam into pieces, squeeze the blocky yam, filter and remove the filter residue to obtain yam juice, add ethanol solution to the yam juice and mix until uniform, let stand for 2.5 hours, and distill to remove the ethanol solution , concentrated to a relative density of 1.5, and dried to obtain a dried Chinese yam paste;

[0052] Step S2: add Scutellaria baicalensis extract, Coptis chinensis extract, Poria cocos extract, dried Chinese yam paste prepared in step S1, and deionized water into the ...

Embodiment 3

[0067] A production process of mesalazine oral liquid. The mesalazine oral liquid is made of the following raw materials in parts by weight: 20 parts of mesalamine, 8 parts of Scutellaria baicalensis extract, 8 parts of Coptidis Rhizoma extract, 8 parts of Poria cocos extract, fresh 15 parts of yam, 2 parts of citric acid, 5 parts of stevia, 30 parts of deionized water;

[0068] The production technology of this mesalamine oral liquid comprises the steps:

[0069] Step S1: Cut fresh yam into pieces, squeeze the blocky yam, filter and remove the filter residue to obtain yam juice, add ethanol solution to the yam juice and mix until uniform, let stand for 3 hours, distill and remove the ethanol solution, Concentrate to a relative density of 1.6, and dry to obtain a dry paste of Chinese yam;

[0070] Step S2: add Scutellaria baicalensis extract, Coptis chinensis extract, Poria cocos extract, dried yam paste prepared in step S1, and deionized water into the reaction kettle, and s...

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Abstract

The invention discloses a production technology of mesalazine oral liquid. The mesalazine oral liquid is prepared from the following raw materials in parts by weight of 10-20 parts of mesalazine, 5-8parts of radix scutellariae extracts, 5-8 parts of rhizoma coptidis extracts, 5-8 parts of poria cocos extracts, 10-15 parts of fresh Chinese yams, 1.5-2 parts of citric acid, 3-5 parts of steviosideand 20-30 parts of deionized water. Through compounding of the mesalazine, the radix scutellariae extract, the rhizoma coptidis extracts and the poria cocos extracts, the prepared oral liquid has better effects on treating ulcerative colitis and higher in efficiency; rhizoma coptidis and radix scutellariae have good liver protecting efficacy, so that the liver can be prevented from being hurt after the mesalazine oral liquid is used for a long time; the citric acid and the stevioside are used, so that the mesalazine oral liquid is better in mouth feel; besides, cane sugar is not added, so thatpatients suffering from diabetes can also take the mesalazine oral liquid for treatment, the application scope is greatly enlarged, and the mesalazine oral liquid is suitable for market promotion.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a production process of mesalazine oral liquid. Background technique [0002] Mesalamine is the active ingredient of SASP for the treatment of ulcerative colitis, and it has a significant inhibitory effect on intestinal wall inflammation; mesalamine can inhibit the synthesis of prostaglandins that cause inflammation and the formation of inflammatory mediator leukotrienes, thereby affecting intestinal Mucosa inflammation plays a significant inhibitory role, mesalazine can inhibit the synthesis of prostaglandins in a dose-dependent manner, and reduce the release of PGE2 in human colonic mucosa. [0003] After the existing mesalamine oral liquid is eaten for a long time, the content of alanine aminotransferase in the patient's liver is gradually increasing, and it will cause the alanine aminotransferase to exceed the standard and then affect the health of the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P1/04A61K9/08A61K47/26A61K47/12A61K31/606A61K36/076A61K36/539A61K36/718
CPCA61K9/0095A61K31/606A61K36/076A61K36/539A61K36/718A61K36/8945A61K47/12A61K47/26A61K2236/331A61K2236/333A61K2236/53A61P1/04A61K2300/00
Inventor 刘加林刘加海
Owner HANGZHOU BROTHER BIO TECH CO LTD
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