The invention provides a transdermal infusion paste preparation for enhancing immunity and a preparation method thereof and relates to a preparation for enhancing the immunity and a preparation method thereof. The transdermal infusion paste preparation for enhancing the immunity is processed by using astragalus, cattail pollen, glossy privet fruit, Chinese angelica, malaytea scurfpea fruit, Indian buead, safflower, pseudoginseng root, tuberfleece flower root, fiveleaf gynostemma herb, indigowoad root, heartleaf houttuynia herb, sweet wormwood herb, nori, leaf of common fig, agaricus, champignon, tremella, hericium erinaceus, lucid ganoderma, royal jelly and propolis as raw materials and by a specific process. The transdermal infusion paste preparation can enhance human immunity, is suitable for senior, children, sick and disabled people with low immunities, has adjuvant therapeutic effect on recurrent diseases caused by low immunity, such as bronchopathy, asthma, allergic disorders, tumor and the like, and is suitable for people with low immunities.