Calcium folinate and phenyl alanine composition and preparation method thereof

A technology of phenylalanine and calcium folinate, applied in the field of medicine, can solve the problems of poor water solubility, toxic effect, and poor stability of calcium folinate, and achieve the effects of excellent appearance, reduction of toxic and side effects, and improvement of water solubility
CN101780083BActive Publication Date: 2012-01-25BEIJING SIHUAN PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING SIHUAN PHARMA
Publication Date
2012-01-25

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Abstract

The invention belongs to the technical field of medicine, in particular to a calcium folinate and phenyl alanine composition and a preparation method thereof, wherein in the composition, the weight ratio of the calcium folinate to the phenyl alanine is 1 / 0.01 to 0.8. The invention also provides the preparation method of a freeze-dried powder preparation of the composition and the application of the composition to the preparation of anemia treating and detoxification medicine.
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Description

1. Technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of calcium folinate and phenylalanine, a preparation method thereof, and an application in preparation of medicines for treating anemia and detoxification. 2. Background technology

[0002] Folic acid is an indispensable component in the process of nucleic acid protein synthesis and erythropoiesis. For some patients with giant red blood cell anemia, it can stimulate the production of red blood cells and platelets. However, folic acid must first be converted into effective forms of formazan in the liver and bone marrow. Acyltetrahydrofolate, then participates in the synthesis of nucleic acids as a coenzyme. Calcium Folinate (Calcium Folinate, CF) is a formylated derivative of the reduced form of folic acid. It is the activated form of folic acid in the body.

[0003] The following figure is the structural formula of calcium folinate:

[0004] [...

Claims

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