Compound separated and extracted from marine penicillium and application thereof

Abstract

The invention belongs to the technical field of preparing compounds, and relates to a compound separated and extracted from marine penicillium and application thereof. The compound is used for preventing and treating in-vitra and in-vivo pseudomonas aeruginosa infection of people or animals, and the chemical formula of the compound which is obtained by fermenting the marine penicillium and has the effect of inhibiting quorum sensing of pseudomonas aeruginosa is 4,6-dimethyl-7-[(1R,2E,4aS,7R,8R,8aR)-1,2.4a,5,6,7,8,8a-octahydro-7-hydroxyl-2-(3-hydroxyl-2-oxygen-propylene)-3,6,8-trimethyl-1-naphthyl]-,(2E,4E,6E)-heptantriene acid, and the molecular formula of the compound is C25H34O5; the compound does not inhibit the growth of the wild type pseudomonas aeruginosa; the quorum-sensing inhibition effect of the compound is concentration-dependent, and is gradually strengthened with the increase of the concentration; virulence factors controlled by the quorum sensing of the pseudomonas aeruginosa can be inhibited; and the compound also has the advantages of readily available raw materials, simple and easily controlled preparation process, obvious sensing inhibition effect and prominent social benefits.

Description

Technical field: The invention belongs to the technical field of marine microorganisms, and relates to a compound isolated from marine Penicillium sp. Prevention and treatment of Pseudomonas infection. Background technique: With the widespread use of antibacterial drugs, bacterial resistance has become more and more serious, and has become a major problem that endangers human health worldwide. Finding new ways to treat bacterial infections has become the frontier and hot spot of life science research. Quorum Sensing (QS) is a bacterial population behavior regulation system that has received widespread attention recently. Studies have found that the pathogenesis of many human or plant pathogenic bacteria is regulated by the QS system, and many bacterial metabolites are also controlled by this system. Therefore, the purpose of weakening the pathogenicity of animal and plant pathogens can be achieved by interfering with the QS system of pathogenic bacteria. Its mechanism of ac...

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Problems solved by technology

By screening marine fungal extracts, marine fungi with quorum sensing inhibitory activity of Pseudomonas aeruginosa are found, and compounds with quorum sensing inhibitory acti

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