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Method for preparing tablets with festoons

A technology of color tablet and tablet compression, applied in the direction of pill transportation, etc., can solve problems such as migration in the same direction, non-uniform color distribution, etc., and achieve the effect of improving compliance and rich colors

Inactive Publication Date: 2010-09-08
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the pigments are water-soluble, which causes them to migrate in the same direction with the migration of water during the drying process of the material, resulting in non-uniform distribution of color

Method used

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  • Method for preparing tablets with festoons
  • Method for preparing tablets with festoons
  • Method for preparing tablets with festoons

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A monochromatic gradient particle with the following composition was prepared:

[0028] material weight

[0029] Compound V 1.25g

[0030] Microcrystalline Cellulose 10.0g

[0031] Cross-linked polyvinylpyrrolidone 0.40g

[0032] Polyvinylpyrrolidone 1.1g

[0033] Talc powder 0.016g

[0034] Ethanol: water 1:1 (7ml)

[0035] The amount of carmine pigment is calculated according to the following arithmetic series formula: (a series of 40 kinds of particles)

[0036] a n = α 1 +(n-1)d(1≤n≤40, d=0.033%, a 1 =0.033%)

[0037] The carmine pigment consumption of 40 kinds of samples is shown in the table below:

[0038] Table 1

[0039] Numbering

Carmine (%)

Numbering

Carmine (%)

1

0.033

21

0.700

2

0.067

22

0.733

3

0.100

23

0.767

4

0.133

24

0.800

5

0.167

25

0.833

6

0.200

26

0.867

7

0.233

27

...

Embodiment 2

[0044] A monochromatic gradient particle with the following composition was prepared:

[0045] material weight

[0046] Compound V 1.25g

[0047] Microcrystalline Cellulose 10.0g

[0048] Cross-linked polyvinylpyrrolidone 0.40g

[0049] Polyvinylpyrrolidone 1.1g

[0050] Talc powder 0.016g

[0051] Ethanol: water 1:1 (6 ~ 8ml)

[0052] The amount of carmine pigment is calculated according to the following geometric sequence formula: (that is, the common ratio of the pigment amount between each particle is q=1.4)

[0053] a n =a 1 q n-1 (1≤n≤25, q=1.4, a 1 =0.022%)

[0054] The consumption of the carmine pigment of 25 kinds of samples is shown in the table below:

[0055] Table 2

[0056] Numbering

Carmine (%)

Numbering

Carmine (%)

1

0.0022

14

0.1771

2

0.0031

15

0.2479

3

0.0044

16

0.3471

4

0.0061

17

0.4859

5

0.0086

18

0.6803

...

Embodiment 3

[0062] A monochromatic gradient particle with the following composition was prepared:

[0063] material weight

[0064] Compound V 1.25g

[0065] Microcrystalline Cellulose 10.0g

[0066] Cross-linked polyvinylpyrrolidone 0.40g

[0067] Polyvinylpyrrolidone 1.1g

[0068] Talc powder 0.016g

[0069] Ethanol: water 1:1 (6 ~ 8ml)

[0070] The amount of carmine pigment is calculated according to the following Fibonacci sequence: (a series of 15 kinds of particles)

[0071] F ( n ) = 1 5 [ ( 1 + 5 2 ) n - ( 1 - 5 2 ) ...

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Abstract

The invention relates to the field of medicinal preparations and health products, in particular to a method for preparing tablets with festoons. The method is characterized by comprising the following steps of: mixing medicaments and pharmaceutic adjuvant to prepare particles; when the medicaments and the pharmaceutic adjuvant are mixed, uniformly dividing the mixture into a plurality of parts and adding various coloring matters with different saturation degrees into the plurality of parts respectively to prepare the particles with different kinds of color saturation; and mixing and tabletting the particles. The method has the advantages of preparing the festoon tablets with gradually changed color saturation by making a breakthrough in color appearance of single color and clear interface in conventional tablet forming; and the obtained festoon tablets have the characteristics of naturally-transitional color saturation, the presentation of elaborate and attractive variegations and the effect of watermarks.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and health products, in particular to a method for preparing festooned tablets. Background technique [0002] The colorful appearance can trigger rich aesthetic imagination and psychological enjoyment, which is conducive to improving the patient's visual experience and treatment compliance; it is conducive to improving the level of preparations and enhancing the brand of preparations; it is conducive to highlighting the logo image of the manufacturer and reducing the risk of product counterfeiting ; It is beneficial for patients to distinguish different medicines and avoid missed or mistaken doses. Foreign pharmaceutical companies have applied for a large number of design patents for pharmaceuticals, covering multiple fields such as the product itself, medical devices, and drug delivery systems. Taking Pfizer as an example, it has dozens of patents for the appearance of tablets. Colorc...

Claims

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Application Information

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IPC IPC(8): A61K9/20
Inventor 朱家壁胡志强杨燕
Owner CHINA PHARM UNIV
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