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Solanum cathayanum alkaloid extract and preparation method and application thereof

A technology of Caulis chinensis and alkaloids, which is applied in the field of medicine, can solve the problems that there are no related reports on the alkaloids of Caulis chinensis, and achieve hepatoprotective effect, strong controllability, and clear drug effect

Inactive Publication Date: 2012-07-11
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant report on the alkaloids of Caulis chinensis

Method used

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  • Solanum cathayanum alkaloid extract and preparation method and application thereof
  • Solanum cathayanum alkaloid extract and preparation method and application thereof
  • Solanum cathayanum alkaloid extract and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0035] Example 1 The preparation method and quality control method of the weak alkaline alkaloids, tertiary amine alkaloids, and water-soluble alkaloids of the present invention.

[0036] 1) Preparation method

[0037] Dried vine whole herb, crushed, added 2% H 2 SO 4 Or extract with 4% hydrochloric acid, filter the extract; extract the filtrate with chloroform, concentrate the chloroform layer to obtain weakly alkaline alkaloids; Add sodium hydroxide to the alkaline aqueous layer to adjust the pH>12, extract with n-butanol, and concentrate the n-butanol layer to obtain water-soluble alkaloids. For the preparation process, see figure 1 .

[0038] 2) Quality testing method of Paifengteng medicinal materials

[0039] The percentage of the mass of alkaloids (calculated as compound SCE-1) in the crude drug is determined by the following quality detection method, which should be no less than 0.25%.

[0040] Preparation of reference solution Accurately weigh 50.0 mg of the com...

Embodiment 2

[0076] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0077] Take 10 g of the weak alkaline alkaloid of Caulis chinensis, add common pharmaceutical excipients, and prepare capsules.

Embodiment 3

[0078] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0079] Take 10 g of the tertiary amine alkaloid of Paifeng vine, add the commonly used excipients in pharmacy, and prepare it into tablets.

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Abstract

The invention provides a solanum cathayanum alkaloid extract, which is one of or a mixture of solanum cathayanum alkalescent alkaloid, solanum cathayanum ebunamine alkaloid and solanum cathayanum water-soluble alkaloid. The invention also provides a preparation method and application of the solanum cathayanum alkaloid extract. The invention also provides application of a compound separated out from solanum cathayanum alkaloid. The solanum cathayanum alkaloid extract has a definite drug effect and strong controllability, and has obvious anti-inflammatory and liver protective effects.

Description

technical field [0001] The invention relates to an alkaloid extract of Caulis chinensis, a preparation method and application thereof, and belongs to the field of medicines. Background technique [0002] Solanum cathayanum is a Solanaceae Solanum plant, herbaceous vine, multi-branched, 0.5-3m long. Stems and leaves are densely covered with multi-noded villous hairs. Alternate leaves, most of which are heart-shaped, light green in color, greenish-yellow in back, most of the leaves are whole and uncracked, a few are 3-lobed, the berries are red when ripe, and the flowering and fruiting period is June-September. It grows in damp places and shrubs on hillsides at an altitude of 200-1400m. It is produced in Badong, Changyang, Zigui, Xingshan and Shennongjia in the Three Gorges area, and is distributed in most parts of the country (see Wuhan Institute of Botany, Chinese Academy of Sciences. Hubei Flora [M]. Wuhan: Hubei Science and Technology Press, 2002: 3.). Paifengteng is al...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07G5/00C07D471/04A61K31/4985A61P29/00A61P1/16A61K36/81
Inventor 周媛邹坤汪鋆植程凡郭志勇杨进但飞君陈剑锋谢明霞董文娟
Owner CHINA THREE GORGES UNIV
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