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Compound chicken colibacillosis resisting veterinary drug preparation

A chicken Escherichia coli and veterinary drug technology, which is applied in the field of compound anti-Escherichia coli veterinary drugs, can solve the problems of no public reports of combined drugs and poor curative effect of systemic Escherichia coli, so as to improve bioavailability and use effect, improve clinical efficacy, and use convenient effect

Inactive Publication Date: 2010-09-22
HEZE PUEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. After oral administration, colistin sulfate is rarely absorbed in the intestinal tract, and the drug is mainly concentrated in the intestinal tract, so the curativ

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0018] Example 1

[0019]

[0020] Preparation method and steps: dry the florfenicol, dextrin, and jiayi powder respectively, accurately weigh them according to their proportions, mix for 30 minutes, obtain a uniformly mixed semi-finished product after quality inspection, and then subpackage, package, and quality inspection. Got. The solubility of florfenicol was tested, and the solubility was very poor.

Example Embodiment

[0021] Example 2

[0022]

[0023] Preparation method and steps: dry the florfenicol, dextrin, and jiayi powder respectively, accurately weigh them according to their proportions, mix for 30 minutes, obtain a uniformly mixed semi-finished product after quality inspection, and then subpackage, package, and quality inspection. Got. Check the solubility, it can be completely dissolved.

[0024]

[0025] Preparation method and steps: dry the florfenicol, dextrin, and jiayi powder respectively, accurately weigh them according to their proportions, mix for 30 minutes, obtain a uniformly mixed semi-finished product after quality inspection, and then subpackage, package, and quality inspection. Got. The solubility is tested, the solubility is poor.

[0026] In summary: the best ratio of co-solvent to florfenicol is 4:1.

[0027] 2. Florfenicol, colistin sulfate soluble powder

[0028] Example 1

[0029]

[0030] Preparation method and steps: Dry the florfenicol, colistin sulfate, de...

Example Embodiment

[0039] Example 3

[0040]

[0041] Preparation method and steps: Dry the florfenicol, colistin sulfate, dextrin, and additive powder separately and accurately weigh them according to their proportions. First add florfenicol and cosolvent and mix for 10 minutes, and then add other ingredients Mix for 20 minutes, semi-finished quality inspection, sub-packaging, packaging, finished quality inspection.

[0042] When in use, 100g of this preparation is mixed with 100L of water for clinical chicken colibacillosis, it is forbidden during the laying period, and the withdrawal period is 7 days.

[0043] The effective rate of the preparation against Escherichia coli is 95%, and the cure rate is 88%. Compared with 15% florfenicol or 15% colistin sulfate, the effective rate and cure rate are both higher than 18%. The effect is very satisfactory.

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Abstract

The invention belongs to a chicken colibacillosis controlling composite in a veterinary drug, which mainly comprises the following components in percentage by weight: 10% of florfenicol, 5% of colistin sulfate, 40% of dextrin and the balance of jiayi powder. The veterinary drug composition is used for treating chicken colibacillosis. The composition has the processing technology that each effective component is accurately weighed according to weight proportion after being dried, the florfenicol is firstly added to be mixed with cosolvent for 10 min, then other components are added for mixing for 20 min, semi-finished products are detected for the quality, sub-packaged and packaged, and the finished products are detected for the quality and put in storage. The use method is that the composition is taken with water in the proportion of 0.1%, and continuous 3-5 days is one course of treatment. The invention has high sensitivity on the chicken colibacillosis, has good effect and low drug resistance, is used conveniently, and has good popularization and application values.

Description

Technical field [0001] The invention relates to a compound veterinary drug against Escherichia coli and its preparation process and clinical efficacy. Background technique [0002] Poultry colibacillosis is mainly caused by Escherichia coli, which has the characteristics of wide incidence, great harm and strong drug resistance. Although E. coli vaccines have been used in some places to prevent epidemics, there are many E. coli serotypes and cannot be widely used. Chicken colibacillosis is still controlled by drugs. According to reports, there are dozens of anti-E.coli drugs, more than 20 commonly used, but most of them will develop resistance within a few years or even one or two years, and there are many E. coli serotypes. The scope of action is limited. The rational use of drugs can improve the efficacy, reduce drug resistance and expand the scope of antibacterial. Reasonable medications include common methods such as combination medication, rotation medication, and shuttle ...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P31/04A61K31/165
Inventor 王彬
Owner HEZE PUEN PHARMA
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