Quick measuring method of aminopyrine mixed in medicine and health-care foods

Abstract

The invention discloses a quick measuring method of aminopyrine mixed in medicine and health-care foods. The method comprises the following steps of: (1) extracting an aminopyrine ingredient in medicine and health-care foods to obtain an extracting solution; (2) extracting the extracting solution by using a solvent, separating an obtained extracting solution and concentrating to obtain residues; (3) dissolving the residues once again to obtain a test article solution; and (4) adding a detecting agent to the test article solution. The invention has rapidness, convenience, strong specificity, high precision, sensitive reaction and wide application scope and is suitable for detecting whether the aminopyrine is mixed in the medicine and the health-care foods or not on site. A quick aminopyrine detection kit can be prepared according to the invention, which can meet the requirement on the supervision and the inspection of the medicine and the health-care foods in wide rural areas and middle-sized and small cities with lagged inspection technical conditions.

Description

technical field [0001] The invention relates to a method for detecting aminopyrine components, in particular to a method for detecting whether aminopyrine components are added in medicines and health foods, especially in antirheumatic traditional Chinese medicine preparations and health foods. Background technique [0002] Aminophenazone, also known as piramidong, dimethylaminoantipyrine, its chemical name is 4-dimethylamino-1,5-dimethyl-2-phenyl-3-pyrazoline Ketones with the molecular formula C 13 h 17 N 3 O. [0003] Aminopyrine has strong antipyretic and analgesic effect, which is slow and long-lasting, and its anti-inflammatory and anti-rheumatic effect is similar to that of aspirin. By inhibiting the synthesis and release of hypothalamic prostaglandins, it restores the reactivity of sensory neurons in the thermoregulatory center and plays an antipyretic effect; by inhibiting cyclooxygenase, it selectively inhibits the synthesis of prostaglandins in the hypothalamic ...

AI Technical Summary

Problems solved by technology

The disadvantages of this method are: (1) the chromatographic resolution is low, the composition of traditional Chinese medicine preparations is complex, and there are many interference factors, it is easy to misjudge some components as aminopyrine. The proximity of the biring will interfere with the detection of the target component

(2) The time for chromatographic development and drying is long, which cannot meet the requirements of rapid determination

(3) Thin-layer chromatography plates need to be stored dry, and the temperature and humidity of the environment have a great influence on the separation effect

(5) A fixed place is required, and it is not suitable for on-site testing with high mobility

The disadvantages are: (1) The instrument is expensive, the sample pretreatment time is long, the chromatographic column is easily polluted, and the analysis cost is high

(3) The instrument has high requirements on the use environment and needs to be placed fixedly, so it is not suitable for on-site testing with large fluidity

These two methods have high resolution and sensitivity, but they are not suitable for rapid screening and on-site detection with high fluidity due to the expensive instruments required, complicated experimental operations, and high requirements for the environment in which the instruments are used.