Matrine vaginal effervescent tablets with bilayer structure and preparation method
A technology of matrine and effervescent preparations, applied in the field of matrine vaginal effervescent tablets with a double-layer structure and its preparation, can solve the problems of increased production cost and difficulty in production quality management, failure to obtain, decrease in release efficiency and uniformity, etc. question
Active Publication Date: 2010-12-15
西安迪赛生物药业有限责任公司
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However, we found that such preparations are either directly neutralized by acid and base, causing the preparation to be very unstable, or the base of the outer layer is neutralized by the acidic environment of the vagina, and it cannot prevent the ingredients in the inner layer of particles from diffusing to the outer layer and Neutralization, not only the preparation is unstable, but also the efficiency of releasing the active ingredient is very low, and the alkali in the outer layer may even bring a certain stimulating effect to the human body. These restrictive factors have led to the fact that this technology has not been practically applied and promoted so far.
Chinese patent application 200410013177.1 involves the compound preparation of matrine and borneol. The increase of active ingredients will bring geometric progression to the difficulty of production quality management, which greatly increases the production cost, and the patent does not specifically involve the innovation of the preparation
However,
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Abstract
The invention discloses a matrine-containing vaginal effervescent preparation. The preparation comprises an alkaline inner layer and an acidic outer layer, is used for treating vaginal infection of women and gynecological inflammation caused thereby, has a reasonable formula and cannot cause adverse reactions such as vulvovaginal stimulation symptoms and the like. In addition, the invention also relates to a preparation method and application of the preparation in preparation of medicaments for treating diseases such as bacterial vaginosis, candidal vulvovaginitis and/or trichomonas vaginitis and the like.
Description
technical field The invention belongs to the field of pharmaceutical preparations of traditional Chinese medicine extracts. Specifically, the invention relates to vaginal effervescent preparations containing matrine, which has an alkaline inner layer and an acidic outer layer, and is used for treating women's vaginal infections and thus Brought gynecological inflammation. In addition, the present invention also relates to the preparation method and application of the preparation. Background technique Gynecological diseases, such as trichomonal vaginitis, monilial vaginitis, chronic cervicitis, senile vaginitis, pelvic inflammatory disease, etc., are common gynecological diseases, which have the characteristics of recurrent attacks and lingering and difficult to heal. The disease is often caused by trichomonas, mold and bacterial infections, and can also be caused by mixed infections. The treatment of this disease is mainly based on topical vaginal application of antibiotic...
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IPC IPC(8): A61K9/46A61K31/4375A61K47/38A61P15/02A61P31/02A61P31/10A61P33/02
Inventor 吴建中
Owner 西安迪赛生物药业有限责任公司
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