Lung adenocarcinoma serum marker protein

A technology of serum markers and lung adenocarcinoma, applied in the field of serum marker proteins of lung adenocarcinoma, can solve the problems of specificity and low sensitivity

Inactive Publication Date: 2010-12-22
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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Problems solved by technology

[0008] At present, the specificity and sensitivity of serum markers related to lung cancer, especially lung adenocarcinoma, are low. Therefor

Method used

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  • Lung adenocarcinoma serum marker protein

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Embodiment Construction

[0038] Lung adenocarcinoma serum marker protein exists in the serum of patients with lung adenocarcinoma, detected by surface-enhanced laser desorption ionization time-of-flight mass spectrometry, using SAX-2 protein chip, including mass spectrum peak m / z14022.9, mass spectrum peak m / z3735.99 or mass spectrum peaks m / z14022.9 and m / z3735.99, the optimal conditions for the detection of the surface-enhanced laser desorption electrochemistry-time-of-flight mass spectrometry are: using the SAX-2 protein chip, using the protein biological system PBS II laser intensity 165, sensitivity 6, action time 90ns.

[0039] There were 31 patients with lung adenocarcinoma, including 19 males with an average age of 61.4 years and 12 females with an average age of 59.6 years. They were all confirmed by pathology, and the patients had not undergone any radiotherapy or chemotherapy. Healthy controls were selected from volunteers with no evidence of disease. There were 31 cases in total, includin...

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Abstract

The invention relates to early diagnosis of lung adenocarcinoma, in particular to a lung adenocarcinoma serum marker protein, and meanwhile provides a screening method, a related decision tree model and a detection method thereof. The screening method comprises the following steps of: detecting serum protein differential expressions of a lung adenocarcinoma patient and a healthy control by adopting an SAX-2 protein chip, screening 102 differential mass spectrum peaks (p is less than 0.001), establishing a lung adenocarcinoma protein mass spectrogram, screening two proteins m/z14022.9 and m/z3735.99 with least p values, and establishing the decision tree model for the two proteins, wherein both the two proteins have very good distinguishing capabilities, the diagnosed lung adenocarcinoma can be obtained by the participation of the two proteins in the decision tree model, the accuracy of the two proteins is 98.387 percent, and a blind test discovers that the accuracy, sensitivity and specificity of diagnosing the lung adenocarcinoma are 100 percent.

Description

Technical field: [0001] The invention relates to early diagnosis of lung adenocarcinoma, in particular to a lung adenocarcinoma serum marker protein, its screening method, its related decision tree model and its detection method. Background technique: [0002] Lung adenocarcinoma is one of the common malignant tumors in clinic. Lung adenocarcinoma patients generally have no obvious symptoms in the early stage, 70% to 80% of the patients are already in the advanced stage when they see a doctor, and the 5-year survival rate is less than 10%. Very early diagnosis or early diagnosis is crucial for successful treatment of lung adenocarcinoma, improved prognosis and increased patient survival. A large number of studies have shown that the occurrence of lung adenocarcinoma has nothing to do with smoking, and its mortality rate is very high. Therefore, the very early diagnosis and very early treatment of lung adenocarcinoma has become a research hotspot at home and abroad. [0003...

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Application Information

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IPC IPC(8): G01N30/72G01N30/14G01N1/28
Inventor 顾国浩蒋敏史进方
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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