Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof

A technology for soft capsules and breast diseases, applied in the field of traditional Chinese medicine, can solve problems such as destruction, reduction of drug efficacy, loss of activity, etc., and achieve the effects of improving moisture resistance, easy to swallow, and improving bioavailability

Active Publication Date: 2012-12-05
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High-temperature granulation is required when making solid preparations such as tablets, granules, and capsules. Lumbrokinase, like other enzymes, will be destroyed due to high temperature and lose its activity, resulting in a decrease in the efficacy of the drug.

Method used

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  • Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof
  • Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof
  • Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] [embodiment 1] the preparation of soft capsule

[0149] Weigh each raw material according to the following weights: orange leaf 1031.25g, salvia miltiorrhiza 1031.25g, saponin thorn 687.5g, Wang Buliuxing 687.5g, toosendan 687.5g, earthworm 687.5g

[0150] Weigh according to the prescription, except Dilong and Wang Buliuxing, the rest of orange leaves and other four flavors are extracted using dynamic continuous countercurrent extraction technology. The above medicinal materials are crushed and put into continuous extraction tanks, extracted with water for 1 hour, and the filtrate is concentrated to relative density. 1.25~1.30 (85°C), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 6 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, and the filtrates were combined , add to the above concentrate, adjust the amount of ethanol to 70%, stir evenly, let it stand for 24 hours, recover th...

Embodiment 2

[0151] [embodiment 2] the preparation of soft capsule

[0152] Weigh each raw material according to the following weights: orange leaf 1031.25g, salvia miltiorrhiza 1031.25g, saponin thorn 687.5g, Wang Buliuxing 687.5g, toosendan 687.5g, earthworm 687.5g

[0153] Weigh according to the prescription, except Dilong and Wang Buliuxing, add water and decoct the other four flavors such as orange leaves twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (85°C ), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 6 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, the combined filtrates were added to the above concentrated solution, Adjust the amount of ethanol to 70%, stir evenly, stand still for 48 hours, recover ethanol and concentrate to a relative density of about 1.25 (50°C), vacuum-dry at 60°C, crush to 120-150 mesh, mi...

Embodiment 3

[0154] [embodiment 3] the preparation of soft capsule

[0155] Weigh each raw material according to the following weights: orange leaf 515.6g, salvia miltiorrhiza 515.6g, saponin thorn 343.8g, 343.8g wangbuliuxin, toosendan 343.8g, earthworm 343.8g

[0156]Weigh according to the prescription, except Dilong and Wang Buliuxing, the rest of orange leaves and other four flavors are extracted using dynamic continuous countercurrent extraction technology. The above medicinal materials are crushed and put into continuous extraction tanks, extracted with water for 1 hour, and the filtrate is concentrated to relative density. 1.25~1.30 (85°C), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 8 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, and the filtrates were combined , add to the above concentrate, adjust the amount of ethanol to 70%, stir evenly, let it stand for 24 hours, recover the ethan...

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Abstract

The invention provides a new preparation of a traditional Chinese medicinal composition for treating breast diseases and a preparation method thereof. The preparation method comprises the following steps of: (1) weighing tangerine leaves, salvia miltiorrhiza, spina gleditsiae, seed of cowherb, toosendan fruit and earthworm; (2) decocting the tangerine leaves, salvia miltiorrhiza, spina gleditsiaeand toosendan fruit in water, mixing decoction, filtering the decoction and concentrating filtrate; (3) carrying out reflux extracting on the earthworm and the seed of cowherb with ethanol, filteringand mixing the filtrate; (4) adding the filtrate obtained in the step (3) to the concentrated filtrate obtained in the step (2), adjusting the ethanol amount to be 70 percent, standing the filtrate, recovering ethanol from the filtrate, concentrating to thick paste with the relative concentration of 1.25 (at 50 DEG C); and (5) reducing the pressure of thick paste obtained in the step (4), drying and crushing, mixing with a suitable amount of dispersed media and pressing into soft capsules. Proved by clinical tests, the curative effect of the mammary block dispelling soft capsules prepared by applying the preparation method is remarkably different from that of mammary block dispelling tablets and granules.

Description

[0001] The present invention is a divisional application, the original application number is 200710065087.0, the original application date is April 3, 2007, and the original application name is the preparation method and product of traditional Chinese medicine soft capsules for treating breast diseases. technical field [0002] The invention relates to a preparation method of a traditional Chinese medicine soft capsule for treating breast diseases and a product thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0003] The theory of traditional Chinese medicine believes that breast distension and hyperplasia are caused by the poor circulation of Qi and blood in the liver meridian. "Danxi Heart Method" said: "Qi and blood are in harmony, and all diseases will not arise. Once there is depression, all diseases will arise. The diseases of the ancient people are mostly born from depression." To vent and hide blood. Emotional depress...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/48A61P15/14A61K35/64A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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