Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof

A technology for soft capsules and breast diseases, applied in the field of traditional Chinese medicine, can solve the problems of destruction, reduction of drug efficacy, loss of activity, etc., and achieve the effects of improving moisture resistance, easy swallowing, and bioavailability

Active Publication Date: 2011-04-27
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High-temperature granulation is required when making solid preparations such as tablets, granules, and capsules. Lumbrokinase, like other enzymes, will be destroyed due to high temperature and lose its activity, resulting in a decrease in the efficacy of the drug.

Method used

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  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof
  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof
  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] [Example 1] Preparation of soft capsules

[0142] Weigh the raw materials according to the following weights: 1031.25g orange leaves 1031.25g salvia 1031.25g saponins 687.5g Wangbuliuxing 687.5g Chuanmuzi 687.5g Dilong 687.5g

[0143] Weigh according to the prescription, except Dilong, Wang Buliu, and other four flavors, such as orange leaves, using dynamic continuous countercurrent extraction technology. The above-mentioned medicinal materials are crushed and placed in a continuous extraction pot, extracted with water for 1 hour, and the filtrate is concentrated to a relative density. It is 1.25~1.30 (85℃), keep it cold and set aside; Dilong and Wang Buliu are extracted twice with 6 times the amount of 70% ethanol at reflux, the first time is 2 hours, the second time is 1 hour, filtered, and the filtrate is combined , Add to the above concentrated solution, adjust the amount of ethanol to 70%, stir evenly, let stand for 24 hours, recover the ethanol and concentrate to a rel...

Embodiment 2

[0144] [Example 2] Preparation of soft capsule

[0145] Weigh the raw materials according to the following weights: 1031.25g orange leaves 1031.25g salvia 1031.25g saponins 687.5g Wangbuliuxing 687.5g Chuanmuzi 687.5g Dilong 687.5g

[0146] Weigh according to the prescription except Dilong and Wang Buliu, and decoct the other four flavors such as orange leaves with water for 1 hour each time. Combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (85℃). ), let cool and set aside; Dilong and Wang Buliu were extracted twice with 6 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, combined the filtrate, and added to the above concentrated solution, Adjust the amount of ethanol to 70%, stir well, let stand for 48 hours, recover the ethanol and concentrate to a relative density of about 1.25 (50°C), vacuum dry at 60°C, crush to 120-150 mesh, mix well, add 1.28 times soybean oil With 0....

Embodiment 3

[0147] [Example 3] Preparation of soft capsules

[0148] Weigh the ingredients according to the following weights: orange leaves 515.6g salvia 515.6g saponins 343.8g Wangbuliuxing 343.8g Chuanmuzi 343.8g Dilong 343.8g

[0149] Weigh according to the prescription, except Dilong, Wang Buliu, and other four flavors, such as orange leaves, using dynamic continuous countercurrent extraction technology. The above-mentioned medicinal materials are crushed and placed in a continuous extraction pot, extracted with water for 1 hour, and the filtrate is concentrated to a relative density. It is 1.25~1.30 (85℃), keep it cold and set aside; Dilong and Wang Buliu are extracted twice with 8 times 70% ethanol at reflux, the first time is 2 hours, the second time is 1 hour, filtered, and the filtrate is combined , Add to the above concentrated solution, adjust the amount of ethanol to 70%, stir evenly, let stand for 24 hours, recover the ethanol and concentrate to a relative density of about 1.25 (...

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Abstract

The invention provides a new preparation of a novel traditional Chinese medicine composition for treating breast diseases and a preparation method thereof. The preparation method comprises the steps that 1) orange leaves, radices salviae miltiorrhizae, spina gleditsiae, saponaria vaccaria, Chinaberry fruit and earthworm are weighed; 2) the orange leaves, radices salviae miltiorrhizae, spina gleditsiae and Chinaberry fruit are boiled in water, the boiled liquid is merged and filtered, and the filtrate is concentrated; 3) the earthworm and the saponaria vaccaria are carried out the reflux extraction by ethanol and filtered and the filtrate is merged; 4) the filtrate obtained by step 3) is added to the concentrated liquid obtained by step 2), the content of the ethanol is adjusted up to 70 percent, the mixed liquid is kept still, the ethanol is recycled from the filtrate, and then the mixed liquid is concentrated to the plaster with the density of 1.25 (at 50 DEG C); 5) the plaster obtained by step 4) is depressured, dried and crushed and then mixed evenly with a proper amount of diffusion media and finally pressed into soft capsules. The clinic tests prove that the efficacy of the soft capsule for eliminating hyperplasia of breast made by the method is remarkably better than tablets and granules for eliminating hyperplasia of breast.

Description

Technical field [0001] The invention relates to a preparation method and product of a traditional Chinese medicine soft capsule for treating breast diseases, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Traditional Chinese medicine theory believes that breast tenderness and breast hyperplasia are caused by poor circulation of Qi and blood in the liver meridian. The "Danxi Heart Method" says: "The qi and blood are in harmony, and all diseases will not occur. If there is depression, all diseases will arise. The diseases of the ancient human body are mostly born in depression." Vent and hide blood. Normally, emotional depression, lack of organization, liver failure and drainage, resulting in stagnation of liver qi; qi is blood handsome, qi is bloody, qi stagnation is blood stasis, qi and blood loss is accumulated in the breast, stomach, and breast. Obstruction of the collaterals and meridians will cause pain and cause breast pai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P15/14A61K35/64A61K9/48A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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