Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof

A technology for soft capsules and breast diseases, applied in the field of traditional Chinese medicine, can solve the problems of reduced curative effect, loss of activity, and destruction of drugs, and achieves the effect of improving curative effect

Active Publication Date: 2008-10-08
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High-temperature granulation is required when making solid preparations such as tablets, granules, and capsules. Lumbrokinase, like other enzymes, will be destroyed due to high temperature and lose its activity, resulting in a decrease in the efficacy of the drug.

Method used

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  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof
  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof
  • Preparation of Chinese medicine soft capsules for curing mammary gland disease and products thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] [embodiment 1] the preparation of soft capsule

[0141] Weigh each raw material according to the following weights: orange leaf 1031.25g, salvia miltiorrhiza 1031.25g, saponin thorn 687.5g, Wang Buliuxing 687.5g, toosendan 687.5g, earthworm 687.5g

[0142] Weigh according to the prescription, except Dilong and Wang Buliuxing, the rest of orange leaves and other four flavors are extracted using dynamic continuous countercurrent extraction technology. The above medicinal materials are crushed and put into continuous extraction tanks, extracted with water for 1 hour, and the filtrate is concentrated to relative density. 1.25~1.30 (85°C), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 6 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, and the filtrates were combined , add to the above concentrate, adjust the amount of ethanol to 70%, stir evenly, let it stand for 24 hours, recover th...

Embodiment 2

[0143] [embodiment 2] the preparation of soft capsule

[0144] Weigh each raw material according to the following weights: orange leaf 1031.25g, salvia miltiorrhiza 1031.25g, saponin thorn 687.5g, Wang Buliuxing 687.5g, toosendan 687.5g, earthworm 687.5g

[0145] Weigh according to the prescription, except Dilong and Wang Buliuxing, add water and decoct the other four flavors such as orange leaves twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (85°C ), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 6 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, the combined filtrates were added to the above concentrated solution, Adjust the amount of ethanol to 70%, stir evenly, stand still for 48 hours, recover ethanol and concentrate to a relative density of about 1.25 (50°C), vacuum-dry at 60°C, crush to 120-150 mesh, mi...

Embodiment 3

[0146] [embodiment 3] the preparation of soft capsule

[0147] Weigh each raw material according to the following weight: orange leaf 515.6g, salvia miltiorrhiza 515.6g, saponin thorn 343.8g, buliuxing 343.8g, toosendan 343.8g, earthworm 343.8g

[0148] Weigh according to the prescription, except Dilong and Wang Buliuxing, the rest of orange leaves and other four flavors are extracted using dynamic continuous countercurrent extraction technology. The above medicinal materials are crushed and put into continuous extraction tanks, extracted with water for 1 hour, and the filtrate is concentrated to relative density. 1.25~1.30 (85°C), let cool, and set aside; Dilong and Wangbuliuxing were extracted twice with 8 times the amount of 70% ethanol under reflux, the first time was 2 hours, the second time was 1 hour, filtered, and the filtrates were combined , add to the above concentrate, adjust the amount of ethanol to 70%, stir evenly, let it stand for 24 hours, recover the ethanol ...

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Abstract

The invention provides a new preparation of a novel traditional Chinese medicine composition for treating breast diseases and a preparation method thereof. The preparation method comprises the steps that 1) orange leaves, radices salviae miltiorrhizae, spina gleditsiae, saponaria vaccaria, Chinaberry fruit and earthworm are weighed; 2) the orange leaves, radices salviae miltiorrhizae, spina gleditsiae and Chinaberry fruit are boiled in water, the boiled liquid is merged and filtered, and the filtrate is concentrated; 3) the earthworm and the saponaria vaccaria are carried out the reflux extraction by ethanol and filtered and the filtrate is merged; 4) the filtrate obtained by step 3) is added to the concentrated liquid obtained by step 2), the content of the ethanol is adjusted up to 70 percent, the mixed liquid is kept still, the ethanol is recycled from the filtrate, and then the mixed liquid is concentrated to the plaster with the density of 1.25 (at 50 DEG C); 5) the plaster obtained by step 4) is depressured, dried and crushed and then mixed evenly with a proper amount of diffusion media and finally pressed into soft capsules. The clinic tests prove that the efficacy of the soft capsule for eliminating hyperplasia of breast made by the method is remarkably better than tablets and granules for eliminating hyperplasia of breast.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine soft capsule for treating breast diseases and a product thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] The theory of traditional Chinese medicine believes that breast distension and hyperplasia are caused by the poor circulation of Qi and blood in the liver meridian. "Danxi Heart Method" said: "Qi and blood are in harmony, and all diseases will not arise. Once there is depression, all diseases will arise. The diseases of the ancient people are mostly born from depression." To vent and hide blood. Emotional depression, wood loss, liver failure, resulting in stagnation of liver qi; qi is handsome in blood, when qi moves, blood flows, and qi stagnation leads to blood stasis, and the circulation of qi and blood accumulates in the breast, stomach and Collateral meridians are obstructed, which can lead to pain and cause...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/48A61P15/14A61K35/64A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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