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Dracocephalum moldavica general flavone orally disintegrating tablet and preparation method thereof

A technology for total flavonoids and orally disintegrating tablets, which is applied to the field of total flavonoids of Xiangqinglan orally disintegrating tablets and their preparation, can solve the problem of drug types that cannot effectively exert their medicinal effects, cannot solve the problem of taking medicine without water, and the total flavonoids of Xiangqinglan. Flavonoids have a bitter taste and other problems, and achieve the effect of overcoming the problem of bitter taste, good disintegration and rapidity, and improving compliance.

Active Publication Date: 2011-11-23
XINJIANG BIOCHEM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent announcement number is CN10537039A discloses a kind of preparation method and application of total flavonoids of sweet green orchid, but, this method makes the drug type that can't effectively exert its medicinal effect, also does not make it into orally disintegrating tablet This modern immediate-release dosage form
[0004] Chinese patent announcement number is that CN101219161A discloses a kind of preparation method of Xiangqinglan dripping pills, but, the dripping pill formulation provided by this method does not solve the bitter problem of the mouthfeel of Xiangqinglan total flavonoids
[0005] Chinese patent announcement number is that CN101264129A is to make the sweet blue orchid extract a kind of sugar-free fruit-flavored sugar-free granule, but, the granule dosage form that this method provides can not solve the patient's problem of anhydrous taking medicine and inconvenience drinking water medication problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: first the total flavonoids of sweet blue orchid is produced through the following process: the sweet green orchid is pulverized into coarse powder, crosses 0.8mm, adds 30 times of amount of 70% ethanol to extract and reflux 2 times, each time for 3 hours, use Filter through a 70 μm sieve, combine the two filtrates, recover ethanol, and concentrate to a concentrated solution with a dry matter of 0.1g / mL fennel; take the above concentrated solution, and use a macroporous resin of type HPD100 for purification. Add 20mL of ethanol concentrate to purify, let it stand for 4h to absorb, and use 40mL of water for each g of dry resin at 40mL·h -1 The flow rate is eluted, and the eluent is discarded; then use 125mL60% ethanol solution for each g of dry resin at 30mL·h -1 Flow rate elution, collect eluate, eluate is concentrated to dry matter ≥ 1g / mL, promptly obtains the total flavonoids of fennel of the present invention. Get again 30 parts of total flavonoids of ...

Embodiment 2

[0024] Embodiment 2: first the total flavonoids of sweet blue orchid are produced through the following process: first sweet green orchid is pulverized into a coarse powder, cross 1mm, add 40 times the amount of 80% ethanol to extract and reflux 3 times, each time for 4 hours, use Filter through an 80 μm sieve, combine the filtrates for 3 times, recover ethanol, and concentrate to a concentrated solution with a dry matter of 0.3g / mL fennel; take the above-mentioned concentrated solution and purify it with a macroporous resin of type HPD 400. Add 8mL of ethanol concentrate to the resin for purification, and after standing for 5h for adsorption, use 50mL of water per g of dry resin at 50mL·h -1 The flow rate is eluted, and the eluent is discarded; and then 100mL70% ethanol solution is used for each g of dry resin at 40mL·h -1 The flow rate is eluted, the eluate is collected, and the eluate is concentrated to a dry matter ≥ 1.15g / mL, to obtain the total flavonoids of the present ...

Embodiment 3

[0025] Embodiment 3: first the total flavonoids of sweet blue orchids are produced by the following process: first sweet green blue orchids are pulverized into coarse powder, pass 1.2mm, add 50 times the amount of 90% ethanol to extract and reflux 4 times, each time for 5 hours, Filter through a 90 μm sieve, combine the filtrates for 4 times, recover ethanol, and concentrate to a concentrated solution with a dry matter of 0.4g / mL fennel; take the above-mentioned concentrated solution and purify it with a macroporous resin of type HPD 600. The dry resin was purified by adding 6mL of ethanol concentrate, and after standing for 6h for adsorption, 60mL of water was used for each g of dry resin at a rate of 60mL·h -1 The flow rate is eluted, and the eluent is discarded; then use 110mL65% ethanol solution for each g of dry resin at 50mL·h -1 Flow rate elution, collect the eluate, concentrate the eluate to a dry matter ≥ 1.2g / mL, and then obtain the total flavonoids of fennel of the ...

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Abstract

The invention discloses a dracocephalum moldavica general flavone orally disintegrating tablet and a preparation method thereof. The dracocephalum moldavica general flavone orally disintegrating tablet is prepared by dosing, pelletizing and tabletting 25 to 30 portions of dracocephalum moldavica general flavone, 9 to18 portions of disintegrating agents, 33 to 85 portions of filling agents, 1 to 5portions of binding agents, 0.5 to 1 portions of lubricant, and 1 to 3 portions of taste correcting agents. Compared with the prior art, the dracocephalum moldavica general flavone orally disintegrating tablet is a novel preparation with favorable taste and quick disintegration, has the characteristics of convenience in taking and quickness in taking effect, can solve the problem of the medicine taking of patients who swallow difficultly, can meet the requirement for the patients who take medicine without water, overcomes the problem of insufferable bitter taste of other tablets without tastecorrection, improves the conformance of patients, has the characteristic of quickness in disintegration, and can disintegrate within 15 to 60 seconds in the oral cavity once being contacted with saliva, thereby being an ideal pharmaceutical preparation for preventing arteriosclerosis, coronary heart disease and angina pectoris disease in a clinic.

Description

technical field [0001] The invention relates to an orally disintegrating tablet of total flavonoids of Xiangqinglan and a preparation method thereof. Background technique [0002] Dracocephalum Moldavica L. is an annual herb of Lamiaceae. It is a local Uighur medicine in Xinjiang and has rich medicinal resources. In Uighur medicine and folk, it is used to treat bronchitis, heart disease, high blood pressure and other diseases. The main components of Xiangqinglan are flavonoids and terpenes. Among them, flavonoids are compounds with anti-oxidation and free radical scavenging effects, and are active components of medicines for preventing and treating arteriosclerosis, coronary heart disease and angina pectoris. [0003] Chinese patent announcement number is CN10537039A discloses a kind of preparation method and application of total flavonoids of sweet green orchid, but, this method makes the drug type that can't effectively exert its medicinal effect, also does not make it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20
Inventor 邢建国王新春何承辉马祖文袁勇王云飞
Owner XINJIANG BIOCHEM PHARMA CO LTD
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