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Black pepper extract, preparation method thereof and application in preparation of medicaments for preventing and treating cough

A technology of black pepper and medicine, which is applied in the field of black pepper extract and its preparation and in the preparation of cough medicine, which can solve the problems of large toxic and side effects

Inactive Publication Date: 2011-05-25
JIANGSU SHENHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, clinical treatment mainly relies on central antitussives and peripheral antitussives, such as dextromethorphan, pentoxyverine, benproperine, and narcodine, etc., which have relatively large toxic and side effects

Method used

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  • Black pepper extract, preparation method thereof and application in preparation of medicaments for preventing and treating cough
  • Black pepper extract, preparation method thereof and application in preparation of medicaments for preventing and treating cough
  • Black pepper extract, preparation method thereof and application in preparation of medicaments for preventing and treating cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of black pepper total alkaloids and black pepper total volatile oil with different piperine content

[0028] 1. Extraction of the total volatile oil of black pepper: take the dried medicinal material, add 10 times the amount of water, and steam distill for 5 hours to extract the volatile oil of black pepper. The extraction rate of volatile oil is 2%, and 9g of crude drug is equivalent to 0.18ml of volatile oil extract.

[0029] 2. Preparation of total black pepper alkaloids containing 10% piperine: take the dried medicinal materials, extract 2 times with 10 times the amount and 8 times the amount of 90% ethanol, each time for one hour, filter, combine the two filtrates, and Recover ethanol under reduced pressure, and dry to obtain the total alkaloids of black pepper containing 10% piperine (the total alkaloids of black pepper in the present invention is the alkaloid part, the same applies throughout).

[0030] 3. Preparation of total black pepper alkaloids ...

Embodiment 2

[0033] Example 2 Antitussive experiment of black pepper total alkaloids containing different contents of piperine

[0034] 1. Preparation of test sample solution:

[0035] The total alkaloids of black pepper containing 10% piperine for testing sample solution: Accurately weigh 10g of total alkaloids of black pepper containing 10% piperine, dissolve in 100ml of 0.4% CMC-Na solution, and mix evenly by ultrasonic to obtain The black pepper total alkaloids test solution containing 10% piperine;

[0036] Containing 50% piperine total alkaloids of black pepper for testing sample solution: Accurately weigh 2.7g of black pepper total alkaloids containing 50% piperine, dissolve in 100ml of 0.4% CMC-Na solution, and ultrasonically mix, namely Obtain the black pepper total alkaloids test solution containing 50% piperine;

[0037] Containing 70% piperine total alkaloids of black pepper for testing sample solution: Accurately weigh 1.9g of black pepper total alkaloids containing 70% pipe...

Embodiment 3

[0048] Example 3 Cough-relieving experiment of black pepper alkaloids, volatile oil and compositions thereof

[0049] 1. Preparation of test solution:

[0050] Positive drug test solution: Accurately measure 39ml of Jizhi syrup, dissolve it in 100ml of 0.4% CMC-Na solution, and mix it by ultrasonic to get the positive drug test solution;

[0051] The test solution for the volatile oil part: accurately measure 0.9ml of volatile oil, dissolve it in 100ml of 0.4% CMC-Na solution, and mix it by ultrasonic to get the test solution for the volatile oil part;

[0052] Alkaloid part test solution: Accurately weigh 1.9g of black pepper total alkaloids containing 70% piperine, dissolve in 100ml of 0.4% CMC-Na solution, and mix with ultrasonic to obtain the total alkaloid test solution;

[0053] The volume / weight ratio is the composition test solution of 5:1: Accurately measure 2.25ml of volatile oil, accurately weigh 0.95g of black pepper total alkaloids containing 70% piperine, and di...

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Abstract

The invention relates to composition containing alkaloid and essential oil which are extracted from black pepper, a preparation method thereof and application in the preparation of medicaments for treating cough, expectoration and upper respiratory tract inflammation which are caused by various reasons. The composition is superior to positive acute bronchitis syrup.

Description

technical field [0001] The invention relates to a composition for extracting alkaloids and volatile oil parts from black pepper, its preparation method, and its application in the preparation of medicines for treating cough, expectoration and upper respiratory tract inflammation induced by various reasons. Background technique [0002] Black pepper is the dry near-ripe fruit of Piper nigrum L., a plant of the family Piperaceae. Harvest when the fruit is dark green in late autumn to next spring, and dry in the sun. The fruit is harvested when it turns red (ripe), soaked in water for several days, wiped off the pulp, and dried in the sun to become white pepper. [0003] Black pepper is spherical, with a diameter of 3.5-5mm. The surface is dark brown, with raised reticular wrinkles, with small style remnants at the top, and scars of self-fruit falling off at the base. Quality is hard, exocarp can be peeled off, endocarp is off-white or light yellow. The cross-section is yel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61P11/00A61P11/14A61K131/00
Inventor 石洪波
Owner JIANGSU SHENHUA PHARMA
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