Atenolol and amlodipine bilayer tablet

Abstract

A bilayer tablet comprising atenolol and amlodipine is disclosed. The bilayer tablet comprises: a first layer which comprises atenolol as an active ingredient and pharmaceutically acceptable excipients, and a second layer which comprises amlodipine or its pharmaceutically acceptable salt as an active ingredient and pharmaceutically acceptable excipients. The bilayer tablet has good stability and good dissolution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a double-layer tablet comprising atenolol and amlodipine, which has better stability and can be used for treating hypertension. Background technique [0002] Cardiovascular disease is one of the most important diseases that seriously affects human health. Hypertension is the most common cardiovascular disease and a major public health problem worldwide. Combination therapy for hypertension has the following advantages over single drug therapy: (1) it is easier to control blood pressure and reduce complications by using two drugs with different mechanisms of action; (2) the combination of two low-dose drugs can avoid side effects ; (3) Fixed low-dose compound preparations can improve compliance. [0003] Chinese Patent Application Publication CN1785185A (application number: 200410096834.3, publication date: June 14, 2006) discloses a novel compound antihypertensive preparation co...

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Problems solved by technology

However, the inventors have further found that designing atenolol and amlodipine into a double-layer tablet will cause new problems, that is, uneven dissolution and / or unqualified dissolution of one or even two active ingredients The problem

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