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Atenolol and amlodipine bilayer tablet
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A double-layer tablet, amlodipine technology, applied in the field of medicine, can solve the problems of unqualified dissolution and uneven dissolution of active ingredients, etc.
Active Publication Date: 2011-06-08
CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
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Problems solved by technology
However, the inventors have further found that designing atenolol and amlodipine into a double-layer tablet will cause new problems, that is, uneven dissolution and / or unqualified dissolution of one or even two active ingredients The problem
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Embodiment 1
[0054] Embodiment 1: Preparation of atenolol-amlodipine bilayer tablet
[0071] According to the prescription listed above, basically carry out tablet making according to the preparation process of Example 1, and the double-layer tablet coating prepared.
Embodiment 3
[0072] Embodiment 3: Preparation of atenolol-amlodipine bilayer tablet
[0079] According to the prescription listed above, basically carry out tablet making according to the preparation technology of embodiment 1.
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Abstract
The invention relates to an atenolol and amlodipinebilayer tablet. Particularly, the invention relates to a bilayer tablet comprising a first tablet layer and a second tablet layer, wherein the first tablet layer contains atenolol as an active constituent and a pharmaceutically acceptable excipient or accessory, and the second tablet layer contains amlodipine as an active constituent or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or accessory. The invention also provides a preparation method of the bilayer tablet. The bilayer tablet provided by the invention not only has favorable stability, but also has favorable dissolution rate.
Description
technical field [0001] The invention belongs to the technical field of medicine and relates to a double-layer tablet containing atenolol and amlodipine. The tablet has better stability and can be used for treating hypertension. Background technique [0002] Cardiovascular disease is one of the most important diseases that seriously affect human health. Hypertension is the most common cardiovascular disease and a major public health problem worldwide. Compared with single drug therapy, combined drug therapy in the treatment of hypertension has the following advantages: (1) It is easier to control blood pressure and reduce complications by using two drugs with different mechanisms of action; (2) The combined use of two low-dose drugs can avoid side effects ; (3) Fixed low-dose compound preparations can improve compliance. [0003] Chinese patent application publication CN1785185A (application number: 200410096834.3, publication date: June 14, 2006) discloses a novel compound...
Claims
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Application Information
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