Atenolol and amlodipine bilayer tablet

Abstract

The invention relates to an atenolol and amlodipine bilayer tablet. Particularly, the invention relates to a bilayer tablet comprising a first tablet layer and a second tablet layer, wherein the first tablet layer contains atenolol as an active constituent and a pharmaceutically acceptable excipient or accessory, and the second tablet layer contains amlodipine as an active constituent or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or accessory. The invention also provides a preparation method of the bilayer tablet. The bilayer tablet provided by the invention not only has favorable stability, but also has favorable dissolution rate.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a double-layer tablet containing atenolol and amlodipine. The tablet has better stability and can be used for treating hypertension. Background technique [0002] Cardiovascular disease is one of the most important diseases that seriously affect human health. Hypertension is the most common cardiovascular disease and a major public health problem worldwide. Compared with single drug therapy, combined drug therapy in the treatment of hypertension has the following advantages: (1) It is easier to control blood pressure and reduce complications by using two drugs with different mechanisms of action; (2) The combined use of two low-dose drugs can avoid side effects ; (3) Fixed low-dose compound preparations can improve compliance. [0003] Chinese patent application publication CN1785185A (application number: 200410096834.3, publication date: June 14, 2006) discloses a novel compound...

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