Atenolol and amlodipine bilayer tablet

A double-layer tablet, amlodipine technology, applied in the field of medicine, can solve the problems of unqualified dissolution and uneven dissolution of active ingredients, etc.

Active Publication Date: 2011-06-08
CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
View PDF2 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors have further found that designing atenolol and amlodipine into a double-layer tablet will cause ne

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Atenolol and amlodipine bilayer tablet
  • Atenolol and amlodipine bilayer tablet
  • Atenolol and amlodipine bilayer tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: Preparation of atenolol-amlodipine bilayer tablet

[0055] Plain Tablet Prescription:

[0056] (1) Atenolol layer:

[0057] Atenolol

10 mg,

Calcium hydrogen phosphate

50mg,

microcrystalline cellulose

7.5 mg,

Sodium carboxymethyl starch

2.5 mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.35 mg;

[0058] (2) Amlodipine layer:

[0059] Amlodipine

1mg (base-based),

Calcium hydrogen phosphate

50mg,

microcrystalline cellulose

7.5 mg,

Sodium carboxymethyl starch

0.75mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.35 mg.

[0060] Prescription of film coating solution (according to 1000ml):

[0061] Hydroxypropyl methylcellulose 20.0g, Tween-808.0g, talcum powder 15.0g, titanium dioxide 10.0g, solvent is 50% ethanol.

[0062] Preparation Process:

[0063] Take prescription amount of atenolol,...

Embodiment 2

[0064] Embodiment 2: the preparation of atenolol-amlodipine bilayer tablet

[0065] Plain Tablet Prescription:

[0066] (1) Atenolol layer:

[0067] Atenolol

15 mg,

Calcium hydrogen phosphate

40mg,

microcrystalline cellulose

10 mg,

Sodium carboxymethyl starch

2 mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.3 mg;

[0068] (2) Amlodipine layer:

[0069] Amlodipine

2mg (calculated by base),

Calcium hydrogen phosphate

40mg,

microcrystalline cellulose

10mg,

Sodium carboxymethyl starch

0.5 mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.3 mg.

[0070] Preparation Process:

[0071] According to the prescription listed above, basically carry out tablet making according to the preparation process of Example 1, and the double-layer tablet coating prepared.

Embodiment 3

[0072] Embodiment 3: Preparation of atenolol-amlodipine bilayer tablet

[0073] Plain Tablet Prescription:

[0074] (1) Atenolol layer:

[0075] Atenolol

5 mg,

Calcium hydrogen phosphate

60mg,

microcrystalline cellulose

5 mg,

Sodium carboxymethyl starch

3 mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.4 mg;

[0076] (2) Amlodipine layer:

[0077] Amlodipine

1mg (base-based),

Calcium hydrogen phosphate

60mg,

microcrystalline cellulose

5 mg,

Sodium carboxymethyl starch

1.0 mg,

pvp K30

Appropriate amount,

Magnesium stearate

0.4mg.

[0078] Preparation Process:

[0079] According to the prescription listed above, basically carry out tablet making according to the preparation technology of embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an atenolol and amlodipine bilayer tablet. Particularly, the invention relates to a bilayer tablet comprising a first tablet layer and a second tablet layer, wherein the first tablet layer contains atenolol as an active constituent and a pharmaceutically acceptable excipient or accessory, and the second tablet layer contains amlodipine as an active constituent or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or accessory. The invention also provides a preparation method of the bilayer tablet. The bilayer tablet provided by the invention not only has favorable stability, but also has favorable dissolution rate.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a double-layer tablet containing atenolol and amlodipine. The tablet has better stability and can be used for treating hypertension. Background technique [0002] Cardiovascular disease is one of the most important diseases that seriously affect human health. Hypertension is the most common cardiovascular disease and a major public health problem worldwide. Compared with single drug therapy, combined drug therapy in the treatment of hypertension has the following advantages: (1) It is easier to control blood pressure and reduce complications by using two drugs with different mechanisms of action; (2) The combined use of two low-dose drugs can avoid side effects ; (3) Fixed low-dose compound preparations can improve compliance. [0003] Chinese patent application publication CN1785185A (application number: 200410096834.3, publication date: June 14, 2006) discloses a novel compound...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4422A61K31/165A61K9/20A61P9/12A61P9/00
CPCA61K31/165A61K9/209A61K31/4422A61K9/2086A61P9/00A61P9/12
Inventor 吴翠栓黄晶晶邱彤吴曼林营亚萍吴涛
Owner CHINA RESOURCES DOUBLE CRANE PHARMA COMPANY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap