Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction

A technology for hypercholesterolemia and composition, which is applied in the directions of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of undisclosed traditional Chinese medicine composition application and the like

Inactive Publication Date: 2011-06-15
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two patents do not disclose the application of the traditional Chinese medicine composition in improving cardiac dysfunction induced by hypercholesterolemia

Method used

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  • Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction
  • Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction
  • Application of traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: the preparation of capsule

[0098] a) The raw material drug formula is:

[0099] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense (made) 13.2g

[0100] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpion 19.8g

[0101] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g;

[0102] b) Crushing process of medicinal materials:

[0103] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are pre...

Embodiment 2

[0109] Embodiment 2: the preparation of tablet

[0110] a) The raw material drug formula is:

[0111] Ginseng 66g Leech 52.8g Wood Beetle 46.2g Frankincense (made) 13.2g

[0112] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpion 59.4g

[0113] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0114] b) Crushing process of medicinal materials:

[0115] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 70-90 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepare...

Embodiment 3

[0121] Embodiment 3: the preparation of pill

[0122] a) The raw material drug formula is:

[0123] Ginseng 39.6g Leech 66g Wood Beetle 46.2g Frankincense (made) 13.2g

[0124] Radix Paeoniae Alba 33g, Dalbergia 13.2g, Sandalwood 13.2g, Scorpion 46.2g

[0125] Cicada slough 46.2g Centipede 6.6g Borneol 33g Suanzaoren (fried) 33g

[0126] b) Crushing process of medicinal materials:

[0127] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powder after powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the powder is 10-20 μm;

[0128] c) Extraction concentration and drying process:

[0129] Add water to extract the volatile oil of Jiangxiang and san...

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Abstract

The invention discloses application of a traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction. The traditional Chinese medicinal composition comprises ginseng, leech, centipede, scorpion, ground beetle, cicada slough, red paeony root, borneol and the like and has the effects of tonifying qi and promoting blood circulation and removing blood stasis and meridian obstruction. A test proves that the traditional Chinese medicinal composition can reduce blood lipid level of a hypercholesterolemia patient, can improve endothelium-dependent vascular dilatation function and vascular flexibility, can enhance application of blood supply capacity from artery to cardiac muscular tissue, can enhance expression of vascular endothelial growth factor (VEGF) genes and protein, and can inhibit angiogenesis of atheromatous plaques so as to effectively improve the hypercholesterolemia-induced cardiac dysfunction.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition. Specifically, the invention relates to the application of a traditional Chinese medicine composition in the preparation of drugs for improving cardiac dysfunction induced by hypercholesterolemia, which belongs to the field of traditional Chinese medicine applications. Background technique [0002] Coronary heart disease has become the leading cause of death in the United States and other major developed countries. The main risk factors for coronary heart disease include advanced age, male sex, high blood pressure, smoking, diabetes, hypercholesterolemia, and family history. It is well known that atherosclerosis is the main pathological basis for the occurrence and development of coronary heart disease. As an important independent risk factor, hypercholesterolemia can induce atherosclerosis and explain nearly 50% of the risk of coronary heart disease. [0003] As ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P3/06A61P9/10A61P9/00A61K35/62A61K35/64A61K31/045A61K35/646A61K35/648
Inventor 吴以岭
Owner HEBEI YILING MEDICINE INST
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