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Production method of pine pollen tablets for treating premature ovarian failure of women

A technology for premature ovarian failure and production method, which is applied in the directions of medical raw materials, sexual diseases, and pill delivery derived from gymnosperm subphylum, can solve the problems of reduced product activity titer, uneven quality, and scarcity of export products, and achieves retention. The effect of functional substance activity, accurate sub-packaging dose, and non-oxidative deterioration

Inactive Publication Date: 2011-07-06
YANTAI NEW ERA HEALTH IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In contrast, although the development and research of pine pollen in my country has been carried out for more than ten years, and a large number of pine pollen products have appeared, the level of comprehensive processing and utilization is not high. The existing pine pollen products on the market have a single type and uneven quality. Not uniform, the degree of intensive processing is not high, export products are even rarer, and the precious pine pollen resources have not been well utilized
[0007] However, due to the long-term storage of the freeze-dried powder of pollen water extract collected traditionally, it is easy to absorb moisture and regain moisture, resulting in product stickiness, which not only affects product quality, reduces product activity and potency, but also affects product consumption, greatly affecting product use.

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0018] 1. Prepare the freeze-dried powder of pollen aqueous extract for the treatment of premature ovarian failure in women:

[0019] 1. Sorting pollen: remove impurities in pine pollen at room temperature.

[0020] 2. Breaking the wall: the pollen that has been removed is broken under the frequency of the grading motor at a frequency of 55-60 Hz and the air source pressure of 0.7-1.0 MPa.

[0021] 3. Soaking and ultrasonic treatment: Soak the pollen after the wall-breaking treatment in water at normal pressure and temperature, and treat it with ultrasonic waves for 20 to 40 minutes.

[0022] 4. Impurity removal: Centrifuge the ultrasonically treated material in a refrigerated centrifuge at 8000-12000 rpm for 10-15 minutes to remove solid impurities and take the supernatant.

[0023] 5. Ultrafiltration: pass the supernatant through a molecular sieve below 5000D at an ambient temperature of 1-5°C, and separate the water-soluble matter with a molecular weight less than 5000D, w...

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Abstract

The invention relates to the technical field of production of tablets, particularly relates to a production method of pine pollen tablets for treating premature ovarian failure of women. The production method comprises the following steps: removing impurities from pine pollen, performing wall-breaking treatment by airflow grinding, soaking in water of normal pressure and temperature, performing ultrasonic treatment, centrifuging with a refrigerated centrifuge at a rotation speed of 8,000-12,000 rpm, collecting supernatant, and separating pine pollen water-soluble extract of molecular weight less than 5,000 D at 1-5 DEG C, and lyophilizing the pine pollen water-soluble extract to obtain pine pollen lyophilized powder with water content less than 5%; and mixing pine pollen lyophilized powder with lecithin, water-soluble starch and microcrystalline cellulose PH102, and tabletting. The pine pollen tablets provided by the invention have the advantages of no adverse effects, no liability of oxidative deterioration, good rehydration, and easy absorption.

Description

technical field [0001] The invention relates to the technical field of tablet production, in particular to a tablet production method for treating premature ovarian failure in women. Background technique [0002] Tablets were developed on the basis of pills and were created in the 1840s. By the end of the 19th century, with the development of tablet presses, they were continuously improved, and the application of tablets developed rapidly. In the past ten years, tablet production technology and mechanical equipment have been greatly developed, such as boiling granulation, full powder direct compression, semi-film coating, etc. The research and production of Chinese medicine tablets began in the 1950s. With the comprehensive research of Chinese medicine chemistry, pharmacology, preparation and clinical aspects, the variety and quantity of Chinese medicine tablets continued to increase, and the technology improved day by day, and the quality of the tablets gradually increased....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61K9/20A61P15/08
Inventor 周斌刘志河石丽花叶满红王桐于建伟鞠东尹利端李明乔强
Owner YANTAI NEW ERA HEALTH IND
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