Oxygen carrying coronary contrast medium and preparation method thereof

Abstract

The invention relates to an oxygen carrying coronary contrast medium, which comprises a contrast medium and a hemoglobin oxygen carrying carrier. According to the condition whether the contrast medium is mixed with the hemoglobin oxygen carrying carrier or not before using, the oxygen carrying coronary contrast medium has the following two types of: 1, storing the hemoglobin oxygen carrying carrier and the contrast medium respectively, wherein the hemoglobin oxygen carrying carrier is contained in dilution solution which is diluted by a diluent until the hemoglobin concentration is between 0.1 and 5g / dL, the pH value of the dilution solution is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the dilution solution in an oxygen saturation state by oxygenating before using; and 2, forming mixed liquor by using the hemoglobin oxygen carrying carrier and the contrast medium, wherein the proportion of the contrast medium to the hemoglobin oxygen carrying carrier is limited by the hemoglobin concentration which is between 0.1 and 5 g / dL in the mixed liquor, and the pH value of the mixed liquor is between 7.0 and 7.4; and making the hemoglobin oxygen carrying carrier contained in the mixed liquor in the oxygen saturation state by oxygenating before using.

Description

technical field [0001] The invention belongs to the field of coronary contrast agents, in particular to an oxygen-carrying coronary contrast agent with heart protection function and a preparation method thereof. Background technique [0002] In recent years, with the widespread development of coronary interventional therapy, the side effects and complications caused by contrast agents have attracted more and more clinical attention. Among them, ventricular fibrillation is one of the most serious complications of coronary angiography, with an incidence rate of 0.38% to 0.9%, and a high fatality rate. Moreover, cholesterol crystal embolism diseases accompanied by coronary angiography and other interventional treatments are also increasing, which must be paid enough attention in clinical work. Although, with the continuous development and improvement of imaging equipment and technology, the incidence of complications of various coronary interventions such as ventricular fibril...

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Problems solved by technology

[0003] The currently used contrast agents (including non-ionic and ionic contrast agents) have no oxygen-carrying function, so it is impossible to avoid the potential ischemic and hypoxic damage to the myocardial tissue during coronary angiography, but there is a risk of aggravation

It has been clinically shown that the side effects and complications of coronary intervention are closely related to the ischemic and hypoxic injury caused by the contrast medium, except that the patient is allergic to the contrast medium itself. Coronary artery spasm, blocking coronary arteries, resulting in reduced blood supply to myocardial tissue; (2) Improper operation, such as catheter insertion too deep, blocking or entering the conolar artery, hindering myocardial blood supply

If the stimulation causes vasospasm and contraction, wrapping the coronary catheter, it may even cause the complete cancellation of unilateral coronary artery blood supply; (3) The injection time of contrast agent is too long and the dose is too large

Because none of the existing contrast agents has the ability to carry oxygen, it will artificially cause myocardial tissue ischemia; (4) The contrast agent is not emptied smoothly, stagnating in the coronary artery for a long time, affecting blood perfusion; (5) Coronary catheter Entering, the effective diameter of the coronary artery is reduced. For patients with severe coronary artery or coronary artery ostium lesions, this will further increase the burden of myocardial ischemia and hypoxia, and induce various complications.

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